64622-45-3

Usage

Uses

Used in Pharmaceutical Industry:
2-Pyridylmethyl 2-(4-isobutylphenyl)propionate is used as an anti-inflammatory agent for the topical treatment of various skin conditions such as acute and chronic eczema, contact dermatitis, and atopic dermatitis. Its selective cyclooxygenase inhibition property makes it effective in reducing inflammation and pain associated with these conditions.
Used in Drug Synthesis:
2-Pyridylmethyl 2-(4-isobutylphenyl)propionate can be synthesized from Ibuprofen, which is a widely used anti-inflammatory drug. This synthesis allows for the development of new pharmaceutical compounds with potential applications in various therapeutic areas.

Originator

Hisamitsu (Japan)

InChI:InChI=1/C19H23NO2/c1-14(2)12-16-7-9-17(10-8-16)15(3)19(21)22-13-18-6-4-5-11-20-18/h4-11,14-15H,12-13H2,1-3H3

Upstream product

• 586-98-1 2-Hydroxymethylpyridine 
• 15687-27-1 ibuprofen 
• 61566-34-5 (+/-)-ibuprofen methyl ester 
• 71381-91-4 (+/-)-2-(4-isobutylphenyl)propanoyl chloride 
• 2387-23-7 1,3-Dicyclohexylurea 

Relevant academic research and scientific papers

METHOD FOR PRODUCING ESTER GROUP-CONTAINING COMPOUND

The present invention provides a novel method for producing an ester group-containing compound and a derivative produced using the compound as a synthetic intermediate. The invention also provides a polymerizable composition containing the compound obtained by the production method and a film-shaped polymer obtained by polymerizing the polymerizable composition. The present invention is a method for producing an ester group-containing compound, the method including a mixing step of mixing a condensing agent, a Bronsted acid, a carboxylic acid, and a phenol or an alcohol to prepare a reaction mixture. The Bronsted acid selected is other than the condensing agent, the carboxylic acid, and the phenol.

Method for producing ester group-containing compound being useful for optical material applications such as optical compensation films

The present invention provides a novel method for producing an ester group-containing compound and a derivative produced by using the compound as a synthetic intermediate. The present invention also provides a polymerizable composition containing the compound obtained by the production method and a film-shaped polymer obtained by polymerizing the polymerizable composition. The present invention is a method for producing an ester group-containing compound, the method including a mixing step of mixing a condensing agent, a Bronsted acid, carboxylic acid, and phenol or alcohol to prepare a reaction mixture. The Bronsted acid is selected from anything other than the condensing agent, the carboxylic acid, and the phenol.

ZINC COMPLEX

A zinc complex characterized in exhibiting an octahedral structure and being configured from repeating units represented by general formula (I): wherein L represents a linker region, and R1 represents a C1-4 alkyl group, which can have a halogen atom.

Alterntnate routes for the synthesis of ibuprofen piconol

New, improved and alternate methods for the synthesis of ibuprofen piconol from ibuprofen and pyridine-2-methanol have been demonstrated with different carboxyl activating groups.

A green chemistry approach to ibuprofen piconol

Ibuprofen piconol synthesis has been described. The use of solid catalyst has demonstrated green chemistry approach with promoted atom economy of 94% compared to the reported 68%.

Pyridylalkyl esters of 2-(p-isobutylphenyl)acetic acid and propionic acids and use

The present invention relates to phenylacetic acid ester derivatives of the following general formula: STR1 wherein, R is selected from the group consisting of lower alkyl (other than ethyl) and substituted lower alkyl, and R' may be a hydrogen or methyl.