64646-31-7

Upstream product

• 2700-22-3 Benzylidenemalononitrile 
• 614-16-4 Benzoylacetonitrile 
• 66727-77-3 Ethyl 2-amino-5-cyano-4,6-diphenyl-4H-pyran-3-carboxylat 
• 109-77-3 malononitrile 
• 20413-05-2 2-benzoyl-3-phenylacrylonitrile 
• 100-52-7 benzaldehyde 

Downstream Products

• 70183-20-9 4-(4-chlorophenyl)-6-oxo-2-phenyl-1,6-dihydro-5-pyrimidinecarbonitrile 
• 61378-38-9 2,4,6-triphenyl-1,4-dihydropyridine-3,5-dicarbonitrile 
• 75238-99-2 1,2-dihydro-2-oxo-4,6-diphenyl-3,5-pyridinedicarbonitrile 
• 75617-37-7 3,5-dicyano-4,6-diphenyl-3,4-dihydropyridin-2(1H)-one 
• 107200-01-1 2-(N-Acetylamino)-4,6-diphenyl-4H-pyran-3,5-dicarbonitrile 

Relevant academic research and scientific papers

Visible-Light-Initiated One-Pot, Three-Component Synthesis of 2-Amino-4 H-pyran-3,5-dicarbonitrile Derivatives

A novel approach for the visible-light-initiated synthesis of 2-amino-4H-pyran-3,5-dicarbonitrile derivatives via a one-pot, three-component reaction of aldehydes or isatins, malononitrile, and α-cyano ketones has been developed. The reaction was carried

Synthetic method of 4H-pyran type compounds

A synthetic method of 4H-pyran type compounds is disclosed. The method includes following steps: adding an aromatic aldehyde compound shown as a formula I, a formyl acetonitrile compound shown as a formula II and propanedinitrile into a Schlenk reactor; t

Preparation method of 2-amino-4,6-diphenyl-4H-pyran-3,5-dinitrile

The invention discloses a preparation method of 2-amino-4,6-diphenyl-4H-pyran-3,5-dinitrile. The preparation method is characterized by comprising the following steps: adding benzaldehyde, malononitrile and benzoylacetonitrile to a reaction flask equipped

Investigation of cis- and trans-4-Fluoroprolines as Enantioselective Catalysts in a Variety of Organic Transformations

Stereoselective fluorination is known to rigidify the ring structure of L-proline, as a result of a combination of electrostatic and hyperconjugative effects associated with the C-F bond. This is a potential strategy for enhancing the enantioselectivity of proline-catalysed reactions. In this study, cis- and trans-4-fluoroprolines were investigated as catalysts in five different organic transformations, including examples of both enamine and iminium ion catalysis. Some significant differences in enantioselectivity were observed between the cis- and trans-isomers of the fluorinated catalysts, confirming that the ring pucker is important. However, no substantial improvements were observed relative to the parent catalyst, L-proline.

Reactions with Heterocyclic β-Enaminoesters: A Novel Synthesis of 2-Amino-3-ethoxycarbonyl-(4H)-pyrans

The reaction of ethyl cyanoacetate with α-cyanochalcone (1) leads to the formation of β-enaminoesters (3) via Michael addition.Compound 3 reacts with phenylmagnesium bromide to give the β-enaminoketone 5.Acetylation of 3 gives the acetyl product 4.Each of compounds 1 and 3 reacts with malononitrile to give β-enaminonitrile 6.Phenylhydrazine reacts with 3 to give the hydrazone 7.Similarly 3-phenyl-5-aminopyrazole reacts with 3 to give the Schiff base 8. - Keywords: Enaminopyrans; Michael addition; Pyrans, cleavage of