646530-82-7Relevant academic research and scientific papers
A METHOD OF PREPARING THE SCOPINE ESTER OF DI-(2-THIENYL)GLYCOLIC ACID, AN INTERMEDIATE IN THE SYNTHESIS OF TIOTROPIUM BROMIDE
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Page/Page column 18, (2013/10/21)
The present invention relates to a preparation method of tiotropium bromide of formula II, comprising the following steps: a) preparation of the scopine ester of formula I by transesterification of methyl di(2thienyl)glycolate of formula IV with scopine of formula III in the presence of a substoichiometric amount of a sterically hindered base selected from the group of alkali salts of branched C3 to C5 alkoxides in an inert solvent, b) isolation of the scopine ester of formula I, and c) quaternization of the scopine ester of formula I with methyl bromide.
Synthesis and evaluation of enzyme inhibitory potential of some derivatives of scopolamine
Shahwar, Durre,Raza, Muhammad Asam,Khan, Tania
experimental part, p. 257 - 266 (2012/06/18)
This study was designed to synthesize and evaluate derivatives of scopolamine (1) as acetylcholine esterase and protease inhibitors. Scopolamine (1) was extracted from the aerial parts of Datura innoxia through bioassay guided fractionation. Five different derivatives of scopolamine (1) were synthesized, and identified through spectroscopic studies. Their acetylcholine esterase (AChE) and trypsin inhibitory potentials were determined through standard protocols and evaluated from the perspective of structure-activity relationship. The synthesized scopolamine derivatives (2-6) showed remarkable AChE inhibitory activity, except for scopoline (6). The results showed higher enzyme inhibition potential of the synthesized compounds (2-5) as compared to scopolamine (1). Maximum inhibition was exhibited by scopolamine N -oxide (89.9 ± 1.2%, IC50 = 37.4 ± 1.1 μM)), followed by scopolamine sulfonic acid (70.3 ± 0.8%, IC50 = 46.9 ± 1.0 μM) and O-methyl scopolamine (66.1 ± 1.2%, IC50 = 94.7 ± 0.8 μM). All derivatives showed moderate activity against trypsin; maximum activity was exhibited by 6 (54.0 ± 1.4%) with IC50 = 621.2 ± 3.7 μM.
Enzymatic Resolution of Tropinone Derivatives
Cramer, Nicolai,Laschat, Sabine,Baro, Angelika
, p. 2178 - 2181 (2007/10/03)
The lipase-mediated kinetic resolution of racemic scopoline [(±)-4] and 6-hydroxytropinone [(±)-7] is reported. Whereas (±)-4 is difficult to resolve due to steric hindrance of the hydroxy function, the resolution of (±)-7 with vinyl acetate as acyl donor gave alcohol (+)-7 and the corresponding acetate (-)-9 with high enantiomeric excess. In case of the optimal result of 99% ee for (+)-7 and 80% ee for (-)-9, an E-value of 35 was calculated. The preparative lipase-catalyzed resolution of (±)-7 resulted in almost enantiopure alcohol (+)-7 with >99% ee after one recrystallization.
An Efficient Route to the Tropane Alkaloids
Mann, John,Barbosa, Luiz-Claudio de Almeida
, p. 787 - 790 (2007/10/02)
We describe the use of diethylzinc in conjunction with polybromo ketones for the production of oxyallyls, and the interception of these intermediates by furans and methyl pyrrole-N-carboxylate.This methodology allows the production of gramme quantities of tropane alkaloids, and 2-substituted 8-oxabicyclooct-6-en-3-ones that have been either difficult or impossible to prepare.
