6820-79-7

Basic information

• Product Name: 9-methyl-3-oxa-9-azatricyclo[3.3.1.0(2,4)]non-7-yl-3'-(acetyloxy)-2'-phenyl propanoate
• Synonyms: 9-methyl-3-oxa-9-azatricyclo[3.3.1.0(2,4)]non-7-yl-3'-(acetyloxy)-2'-phenyl propanoate
• CAS NO: 6820-79-7
• Molecular Weight: 345.395
• Mol File: 6820-79-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 9-methyl-3-oxa-9-azatricyclo[3.3.1.0(2,4)]non-7-yl-3'-(acetyloxy)-2'-phenyl propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: 9-methyl-3-oxa-9-azatricyclo[3.3.1.0(2,4)]non-7-yl-3'-(acetyloxy)-2'-phenyl propanoate(6820-79-7)
• EPA Substance Registry System: 9-methyl-3-oxa-9-azatricyclo[3.3.1.0(2,4)]non-7-yl-3'-(acetyloxy)-2'-phenyl propanoate(6820-79-7)

Safety Data

• Hazardous Substances Data: 6820-79-7(Hazardous Substances Data)

Upstream product

• 75-36-5 acetyl chloride 
• 51-34-3 scopolamine 
• 14510-37-3 3-acetoxy-2-phenyl-propionyl chloride 
• 108-24-7 acetic anhydride 
• 114-49-8 hyoscine hydrobromide 

Downstream Products

• 492-38-6 2-phenylacrylic acid 
• 64-19-7 acetic acid 
• 487-27-4 (+/-)-scopoline 
• 26352-27-2 (-)-Azoniaspiro-(norscopolamin-8,1'-pyrrolidin)-bromid 
• 4684-28-0 Norscopolamine 
• 25650-58-2 (-)-Formylnorscopollamin 
• 25645-57-2 (-)-N-Chlorformyl-O-acetylnorscopolamin 
• 26516-78-9 (S)-3-acetoxy-2-phenyl-propionic acid 9-cyano-(1rN,2tH,4tH,5cN)-3-oxa-9-aza-tricyclo[3.3.1.0^2,4]non-7t-yl ester 
• 64307-65-9 (S)-3-acetoxy-2-phenyl-propionic acid 9-(5-dimethylamino-naphthalene-1-sulfonyl)-(1rN,2tH,4tH,5cN)-3-oxa-9-aza-tricyclo[3.3.1.0^2,4]non-7t-yl ester 

Relevant articles and documents

Synthesis and evaluation of enzyme inhibitory potential of some derivatives of scopolamine

This study was designed to synthesize and evaluate derivatives of scopolamine (1) as acetylcholine esterase and protease inhibitors. Scopolamine (1) was extracted from the aerial parts of Datura innoxia through bioassay guided fractionation. Five different derivatives of scopolamine (1) were synthesized, and identified through spectroscopic studies. Their acetylcholine esterase (AChE) and trypsin inhibitory potentials were determined through standard protocols and evaluated from the perspective of structure-activity relationship. The synthesized scopolamine derivatives (2-6) showed remarkable AChE inhibitory activity, except for scopoline (6). The results showed higher enzyme inhibition potential of the synthesized compounds (2-5) as compared to scopolamine (1). Maximum inhibition was exhibited by scopolamine N -oxide (89.9 ± 1.2%, IC50 = 37.4 ± 1.1 μM)), followed by scopolamine sulfonic acid (70.3 ± 0.8%, IC50 = 46.9 ± 1.0 μM) and O-methyl scopolamine (66.1 ± 1.2%, IC50 = 94.7 ± 0.8 μM). All derivatives showed moderate activity against trypsin; maximum activity was exhibited by 6 (54.0 ± 1.4%) with IC50 = 621.2 ± 3.7 μM.