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High quality Scopine supplier in China
Cas No: 498-45-3
No Data 1 Metric Ton 30 Metric Ton/Month Simagchem Corporation Contact Supplier
(1R,2R,4S,5S,7s)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-ol
Cas No: 498-45-3
USD $ 2000.0-2000.0 / Kilogram 20 Kilogram 10 Metric Ton/Month Hebei yanxi chemical co.,LTD. Contact Supplier
Scopine
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No Data 10 Milligram Amadis Chemical Co., Ltd. Contact Supplier
Scopine
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No Data 1 Gram 100 Metric Ton/Month Anhui Dexinjia Biopharm Co., Ltd Contact Supplier
Scopine
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No Data No Data No Data Chemwill Asia Co., Ltd. Contact Supplier
Scopine Manufacturer/High quality/Best price/In stock
Cas No: 498-45-3
USD $ 2.0-2.0 / Gram 10 Gram 1-1000 Kilogram/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
Factory Supply Scopine
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USD $ 1.0-3.0 / Gram 1 Gram 5 Kilogram/Day Ality Chemical Corporation Contact Supplier
498-45-3
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No Data 1 Kilogram 1 Metric Ton/Year Henan Tianfu Chemical Co., Ltd. Contact Supplier
Pharmaceutical Grade CAS 498-45-3 with competitive price
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USD $ 139.0-210.0 / Kilogram 1 Kilogram 1000 Kilogram/Day Zhuozhou Wenxi import and Export Co., Ltd Contact Supplier
BLOOM TECH Advanced API/Technology support Scopine CAS 498-45-3
Cas No: 498-45-3
No Data 1 Gram 3 Metric Ton/Month Shaanxi BLOOM TECH Co.,Ltd Contact Supplier

498-45-3 Usage

Chemical Properties

White to white crystal powder
InChI:InChI=1/C8H13NO2/c1-9-5-2-4(10)3-6(9)8-7(5)11-8/h4-8,10H,2-3H2,1H3/t4?,5-,6+,7-,8+

498-45-3 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
TCI America (S0912)  Scopine  >98.0%(GC)(T) 498-45-3 200mg 1,590.00CNY Detail

498-45-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name (1R,2R,4S,5S,7s)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-ol

1.2 Other means of identification

Product number -
Other names Scopine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:498-45-3 SDS

498-45-3Synthetic route

Conditions
ConditionsYield
With 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine In toluene at 25℃; for 48h;99.3%
Stage #1: scopolamine With sodium tetrahydroborate In ethanol at 0 - 20℃; for 24h;
Stage #2: With hydrogenchloride In diethyl ether; ethanol at 20℃; for 24h;
50%
With ammonium chloride; ammonia at 30℃;
hyoscine hydrobromide
114-49-8

hyoscine hydrobromide

scopine
498-45-3

scopine

Conditions
ConditionsYield
With sodium tetrahydroborate In ethanol at 20℃; Cooling with ice;87%
scopine t-butyldimethylsilyl ether
182054-94-0

scopine t-butyldimethylsilyl ether

scopine
498-45-3

scopine

Conditions
ConditionsYield
With tert-butyl-ammonium fluoride82%
With tetrabutyl ammonium fluoride In tetrahydrofuran for 18h;81%
scopine benzyl ether
132622-34-5, 132697-33-7

scopine benzyl ether

scopine
498-45-3

scopine

Conditions
ConditionsYield
With hydrogenchloride; hydrogen; potassium carbonate; palladium on activated charcoal 1) EtOH, 5 atm, r.t, 12h; Yield given. Multistep reaction;
(-)-scopolamine

(-)-scopolamine

scopine
498-45-3

scopine

Conditions
ConditionsYield
With NH3-NH4Cl-buffer solution
With bis-1-chloroethyl ether anschliessende Hydrolyse mit wss. Ba(OH)2 und dann mit wss. HCl;
O-acetyl-scopine

O-acetyl-scopine

scopine
498-45-3

scopine

Conditions
ConditionsYield
With sodium hydroxide; acetone
Tropilidenoxid
33250-14-5

Tropilidenoxid

scopine
498-45-3

scopine

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: LiAlH4 / diethyl ether / 1 h
2: Me4N(1+)IO4(1-) / CH2Cl2
3: 1.) Me4N(1+)*IO4(1-), 2.) Imidazole, 3.) Na(Hg), Na3PO4, 4.) MCPBA
4: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 10 min, 2.) THF, hexane, RT, 1.5 h
5: 64 percent / LiCl / dimethylsulfoxide / 1.5 h / 55 °C
6: 82 percent / NaH / tetrahydrofuran; 1,2-dimethoxy-ethane / 3 h / 20 - 50 °C
7: 95 percent / LiAlH4 / diethyl ether / 2 h / Heating
8: 81 percent / TBAF / tetrahydrofuran / 18 h
View Scheme
cyclohepta-3,5-dien-1-ol
1121-63-7

cyclohepta-3,5-dien-1-ol

scopine
498-45-3

scopine

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: Me4N(1+)IO4(1-) / CH2Cl2
2: 1.) Me4N(1+)*IO4(1-), 2.) Imidazole, 3.) Na(Hg), Na3PO4, 4.) MCPBA
3: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 10 min, 2.) THF, hexane, RT, 1.5 h
4: 64 percent / LiCl / dimethylsulfoxide / 1.5 h / 55 °C
5: 82 percent / NaH / tetrahydrofuran; 1,2-dimethoxy-ethane / 3 h / 20 - 50 °C
6: 95 percent / LiAlH4 / diethyl ether / 2 h / Heating
7: 81 percent / TBAF / tetrahydrofuran / 18 h
View Scheme
Multi-step reaction with 9 steps
1: NaH / tetrahydrofuran / 15 h / 50 °C
2: 63 percent / LiCl, p-benzoquinone, glacial acetic acid / Pd(OAc)2 / acetic acid / 36 h
3: 96 percent / DIBAL / tetrahydrofuran; hexane / 0.75 h / 2 °C
4: 66 percent / Pd(PPh3)4 / acetonitrile / 4 h
5: 76 percent / LiCl, MsCl, 2,4,6-trimethylpyridine / dimethylformamide / 0 deg C to r.t., overnight
6: 86 percent / m-CPBA / CH2Cl2 / 48 h / Ambient temperature
7: 95 percent / K2CO3 / methanol / 56 h / Ambient temperature
8: 1) naphthalene, Na / 1) THF, -78 deg C, 30 min
9: 1) aq.2M HCl, H2, 2) 10percent aq. K2CO3 / 1) 10percent Pd/C / 1) EtOH, 5 atm, r.t, 12h
View Scheme
Cyclohepta-1,3,5-triene
544-25-2

Cyclohepta-1,3,5-triene

norcaradiene-(2.4)

norcaradiene-(2.4)

scopine
498-45-3

scopine

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: aq. CH3COOOH, Na2CO3 / CH2Cl2 / 3 h / 0 °C
2: LiAlH4 / diethyl ether / 1 h
3: Me4N(1+)IO4(1-) / CH2Cl2
4: 1.) Me4N(1+)*IO4(1-), 2.) Imidazole, 3.) Na(Hg), Na3PO4, 4.) MCPBA
5: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 10 min, 2.) THF, hexane, RT, 1.5 h
6: 64 percent / LiCl / dimethylsulfoxide / 1.5 h / 55 °C
7: 82 percent / NaH / tetrahydrofuran; 1,2-dimethoxy-ethane / 3 h / 20 - 50 °C
8: 95 percent / LiAlH4 / diethyl ether / 2 h / Heating
9: 81 percent / TBAF / tetrahydrofuran / 18 h
View Scheme
1β-hydroxy-4β-<(benzyloxycarbonyl)amino>-6-<(t-butyldimethylsilyl)oxy>cyclohept-2-ene

1β-hydroxy-4β-<(benzyloxycarbonyl)amino>-6-<(t-butyldimethylsilyl)oxy>cyclohept-2-ene

scopine
498-45-3

scopine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 68 percent / MCPBA / CH2Cl2 / 3 h / Ambient temperature
2: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 10 min, 2.) THF, hexane, RT, 1.5 h
3: 64 percent / LiCl / dimethylsulfoxide / 1.5 h / 55 °C
4: 82 percent / NaH / tetrahydrofuran; 1,2-dimethoxy-ethane / 3 h / 20 - 50 °C
5: 95 percent / LiAlH4 / diethyl ether / 2 h / Heating
6: 81 percent / TBAF / tetrahydrofuran / 18 h
View Scheme
Multi-step reaction with 6 steps
1: MCPBA / CH2Cl2 / 3 h / Ambient temperature
2: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 10 min, 2.) THF, hexane, RT, 1.5 h
3: 64 percent / LiCl / dimethylsulfoxide / 1.5 h / 55 °C
4: 82 percent / NaH / tetrahydrofuran; 1,2-dimethoxy-ethane / 3 h / 20 - 50 °C
5: 95 percent / LiAlH4 / diethyl ether / 2 h / Heating
6: 81 percent / TBAF / tetrahydrofuran / 18 h
View Scheme
N-benzyloxycarbonyl-3α-<(t-butyldimethylsilyl)oxy>-6β,7β-epoxy-8-azabicyclo<3.2.1>octane
182054-91-7

N-benzyloxycarbonyl-3α-<(t-butyldimethylsilyl)oxy>-6β,7β-epoxy-8-azabicyclo<3.2.1>octane

scopine
498-45-3

scopine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 95 percent / LiAlH4 / diethyl ether / 2 h / Heating
2: 81 percent / TBAF / tetrahydrofuran / 18 h
View Scheme
1β-hydroxy-2β,3β-epoxy-4β-<(benzyloxycarbonyl)amino>-6α-<(t-butyldimethylsilyl)oxy>cycloheptane

1β-hydroxy-2β,3β-epoxy-4β-<(benzyloxycarbonyl)amino>-6α-<(t-butyldimethylsilyl)oxy>cycloheptane

scopine
498-45-3

scopine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 10 min, 2.) THF, hexane, RT, 1.5 h
2: 64 percent / LiCl / dimethylsulfoxide / 1.5 h / 55 °C
3: 82 percent / NaH / tetrahydrofuran; 1,2-dimethoxy-ethane / 3 h / 20 - 50 °C
4: 95 percent / LiAlH4 / diethyl ether / 2 h / Heating
5: 81 percent / TBAF / tetrahydrofuran / 18 h
View Scheme
1α-chloro-2β,3β-epoxy-4β-<(benzyloxycarbonyl)amino>-6α-<(t-butyldimethylsilyl)oxy>cycloheptane

1α-chloro-2β,3β-epoxy-4β-<(benzyloxycarbonyl)amino>-6α-<(t-butyldimethylsilyl)oxy>cycloheptane

scopine
498-45-3

scopine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 82 percent / NaH / tetrahydrofuran; 1,2-dimethoxy-ethane / 3 h / 20 - 50 °C
2: 95 percent / LiAlH4 / diethyl ether / 2 h / Heating
3: 81 percent / TBAF / tetrahydrofuran / 18 h
View Scheme
1β-<(p-toluenesulphonyl)oxy>-2β,3β-epoxy-4β-<(benzyloxycarbonyl)amino>-6α-<(t-butyldimethylsilyl)oxy>cycloheptane

1β-<(p-toluenesulphonyl)oxy>-2β,3β-epoxy-4β-<(benzyloxycarbonyl)amino>-6α-<(t-butyldimethylsilyl)oxy>cycloheptane

scopine
498-45-3

scopine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 64 percent / LiCl / dimethylsulfoxide / 1.5 h / 55 °C
2: 82 percent / NaH / tetrahydrofuran; 1,2-dimethoxy-ethane / 3 h / 20 - 50 °C
3: 95 percent / LiAlH4 / diethyl ether / 2 h / Heating
4: 81 percent / TBAF / tetrahydrofuran / 18 h
View Scheme
N-benzyloxycarbonyl-3α-hydroxy-6-aza-7-oxabicyclo[3.2.2]non-8-ene

N-benzyloxycarbonyl-3α-hydroxy-6-aza-7-oxabicyclo[3.2.2]non-8-ene

scopine
498-45-3

scopine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 1.) Me4N(1+)*IO4(1-), 2.) Imidazole, 3.) Na(Hg), Na3PO4, 4.) MCPBA
2: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 10 min, 2.) THF, hexane, RT, 1.5 h
3: 64 percent / LiCl / dimethylsulfoxide / 1.5 h / 55 °C
4: 82 percent / NaH / tetrahydrofuran; 1,2-dimethoxy-ethane / 3 h / 20 - 50 °C
5: 95 percent / LiAlH4 / diethyl ether / 2 h / Heating
6: 81 percent / TBAF / tetrahydrofuran / 18 h
View Scheme
6-(benzyloxy)-1,3-cycloheptadiene
115522-58-2

6-(benzyloxy)-1,3-cycloheptadiene

scopine
498-45-3

scopine

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 63 percent / LiCl, p-benzoquinone, glacial acetic acid / Pd(OAc)2 / acetic acid / 36 h
2: 96 percent / DIBAL / tetrahydrofuran; hexane / 0.75 h / 2 °C
3: 66 percent / Pd(PPh3)4 / acetonitrile / 4 h
4: 76 percent / LiCl, MsCl, 2,4,6-trimethylpyridine / dimethylformamide / 0 deg C to r.t., overnight
5: 86 percent / m-CPBA / CH2Cl2 / 48 h / Ambient temperature
6: 95 percent / K2CO3 / methanol / 56 h / Ambient temperature
7: 1) naphthalene, Na / 1) THF, -78 deg C, 30 min
8: 1) aq.2M HCl, H2, 2) 10percent aq. K2CO3 / 1) 10percent Pd/C / 1) EtOH, 5 atm, r.t, 12h
View Scheme
1β-hydroxy-4β-chloro-6α-(benzyloxy)-2-cycloheptene
132622-29-8

1β-hydroxy-4β-chloro-6α-(benzyloxy)-2-cycloheptene

scopine
498-45-3

scopine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 66 percent / Pd(PPh3)4 / acetonitrile / 4 h
2: 76 percent / LiCl, MsCl, 2,4,6-trimethylpyridine / dimethylformamide / 0 deg C to r.t., overnight
3: 86 percent / m-CPBA / CH2Cl2 / 48 h / Ambient temperature
4: 95 percent / K2CO3 / methanol / 56 h / Ambient temperature
5: 1) naphthalene, Na / 1) THF, -78 deg C, 30 min
6: 1) aq.2M HCl, H2, 2) 10percent aq. K2CO3 / 1) 10percent Pd/C / 1) EtOH, 5 atm, r.t, 12h
View Scheme
1β-acetoxy-4β-chloro-6α-(benzyloxy)-2-cycloheptene
115522-57-1, 150338-86-6

1β-acetoxy-4β-chloro-6α-(benzyloxy)-2-cycloheptene

scopine
498-45-3

scopine

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 96 percent / DIBAL / tetrahydrofuran; hexane / 0.75 h / 2 °C
2: 66 percent / Pd(PPh3)4 / acetonitrile / 4 h
3: 76 percent / LiCl, MsCl, 2,4,6-trimethylpyridine / dimethylformamide / 0 deg C to r.t., overnight
4: 86 percent / m-CPBA / CH2Cl2 / 48 h / Ambient temperature
5: 95 percent / K2CO3 / methanol / 56 h / Ambient temperature
6: 1) naphthalene, Na / 1) THF, -78 deg C, 30 min
7: 1) aq.2M HCl, H2, 2) 10percent aq. K2CO3 / 1) 10percent Pd/C / 1) EtOH, 5 atm, r.t, 12h
View Scheme
1β-(p-toluenesulfonamido)-4-chloro-6α-(benzyloxy)-2-cycloheptene
132622-31-2, 132697-30-4

1β-(p-toluenesulfonamido)-4-chloro-6α-(benzyloxy)-2-cycloheptene

scopine
498-45-3

scopine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 86 percent / m-CPBA / CH2Cl2 / 48 h / Ambient temperature
2: 95 percent / K2CO3 / methanol / 56 h / Ambient temperature
3: 1) naphthalene, Na / 1) THF, -78 deg C, 30 min
4: 1) aq.2M HCl, H2, 2) 10percent aq. K2CO3 / 1) 10percent Pd/C / 1) EtOH, 5 atm, r.t, 12h
View Scheme
1β-(p-toluenesulfonamido)-2β,3β-epoxy-4α-chloro-6α-(benzyloxy)-2-cycloheptene
132622-32-3

1β-(p-toluenesulfonamido)-2β,3β-epoxy-4α-chloro-6α-(benzyloxy)-2-cycloheptene

scopine
498-45-3

scopine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 95 percent / K2CO3 / methanol / 56 h / Ambient temperature
2: 1) naphthalene, Na / 1) THF, -78 deg C, 30 min
3: 1) aq.2M HCl, H2, 2) 10percent aq. K2CO3 / 1) 10percent Pd/C / 1) EtOH, 5 atm, r.t, 12h
View Scheme
1β-(p-toluenesulfonamido)-4β-hydroxy-6α-(benzyloxy)-2-cycloheptene
132622-30-1, 132697-31-5

1β-(p-toluenesulfonamido)-4β-hydroxy-6α-(benzyloxy)-2-cycloheptene

scopine
498-45-3

scopine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 76 percent / LiCl, MsCl, 2,4,6-trimethylpyridine / dimethylformamide / 0 deg C to r.t., overnight
2: 86 percent / m-CPBA / CH2Cl2 / 48 h / Ambient temperature
3: 95 percent / K2CO3 / methanol / 56 h / Ambient temperature
4: 1) naphthalene, Na / 1) THF, -78 deg C, 30 min
5: 1) aq.2M HCl, H2, 2) 10percent aq. K2CO3 / 1) 10percent Pd/C / 1) EtOH, 5 atm, r.t, 12h
View Scheme
3α-(benzyloxy)-6β,7β-epoxy-8-(p-toluenesulfonyl)-1β-azabicyclo<3.2.1>octane
132622-33-4, 132697-32-6

3α-(benzyloxy)-6β,7β-epoxy-8-(p-toluenesulfonyl)-1β-azabicyclo<3.2.1>octane

scopine
498-45-3

scopine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1) naphthalene, Na / 1) THF, -78 deg C, 30 min
2: 1) aq.2M HCl, H2, 2) 10percent aq. K2CO3 / 1) 10percent Pd/C / 1) EtOH, 5 atm, r.t, 12h
View Scheme
hyoscine-N-butyl bromide
149-64-4

hyoscine-N-butyl bromide

scopine
498-45-3

scopine

Conditions
ConditionsYield
With ruthenium trichloride; potassium metaperiodate; diperiodatocuprate(III) dihydrate; water; potassium nitrate; potassium hydroxide at 28℃; for 6h; Kinetics; Catalytic behavior; Concentration; Temperature; Inert atmosphere;
scopine
498-45-3

scopine

methyl iodide
74-88-4

methyl iodide

(1R,2R,4S,5S,7S)-7-hydroxy-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-iumiodide (N-methylscopinium)
21662-36-2

(1R,2R,4S,5S,7S)-7-hydroxy-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-iumiodide (N-methylscopinium)

Conditions
ConditionsYield
In dichloromethane at 20℃; for 48h; Inert atmosphere;85%
2,2-di(thiophen-2-yl)acetic acid
4408-82-6

2,2-di(thiophen-2-yl)acetic acid

scopine
498-45-3

scopine

C18H19NO3S2
1336913-21-3

C18H19NO3S2

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 16h; Product distribution / selectivity;83%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 16h; Reagent/catalyst; Solvent; Concentration;83%
With dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 16h; Product distribution / selectivity;
scopine
498-45-3

scopine

chlorambucil
305-03-3

chlorambucil

C22H30Cl2N2O3

C22H30Cl2N2O3

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 4h;82.3%
hydroxy-di-thiophen-2-yl-acetic acid methyl ester
26447-85-8

hydroxy-di-thiophen-2-yl-acetic acid methyl ester

scopine
498-45-3

scopine

N-demethyltiotropium
136310-64-0

N-demethyltiotropium

Conditions
ConditionsYield
With potassium tert-butylate; 1-butyl-3-methylimidazolium Tetrafluoroborate In tetrahydrofuran at 20℃; for 18h; Solvent; Concentration; Reagent/catalyst; Temperature; Time; Molecular sieve;73%
Stage #1: hydroxy-di-thiophen-2-yl-acetic acid methyl ester; scopine at 70℃; under 210 Torr; for 1h;
Stage #2: With sodium hydride at 70℃; under 210 Torr; for 3h;
42%
With sodium hydride In toluene; mineral oil at 90℃; for 2h;33%
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 70℃; under 15.0015 Torr; for 19h;
benzoic acid
65-85-0

benzoic acid

scopine
498-45-3

scopine

(1R,2R,4S,5S,7r)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-yl benzoate

(1R,2R,4S,5S,7r)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-yl benzoate

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at -35 - 20℃;67.9%
hydroxy-di-thiophen-2-yl-acetic acid methyl ester
26447-85-8

hydroxy-di-thiophen-2-yl-acetic acid methyl ester

scopine
498-45-3

scopine

A

N-demethyltiotropium
136310-64-0

N-demethyltiotropium

B

scopoline

scopoline

C

di-(2-thienyl)glycolic acid scopoline ester

di-(2-thienyl)glycolic acid scopoline ester

Conditions
ConditionsYield
Stage #1: hydroxy-di-thiophen-2-yl-acetic acid methyl ester; scopine With sodium t-butanolate In tetrahydrofuran; toluene at 70 - 90℃; under 375.038 Torr; for 4.41667h; Inert atmosphere;
Stage #2: With hydrogenchloride In dichloromethane; water Cooling with ice;
Stage #3: With sodium carbonate In water Reagent/catalyst; Solvent; Time; Temperature; Pressure; Concentration; Overall yield = 37.2 g;
A 58%
B 5.3 %Chromat.
C 6.1 %Chromat.
Stage #1: hydroxy-di-thiophen-2-yl-acetic acid methyl ester; scopine With potassium tert-butylate In toluene at 70 - 90℃; under 225.023 - 300.03 Torr; for 4.25h; Inert atmosphere;
Stage #2: With hydrogenchloride In dichloromethane; water Cooling with ice;
Stage #3: With sodium carbonate In water Reagent/catalyst; Temperature; Time; Overall yield = 0.82 g;
A 41%
B 18.4 %Chromat.
C 5.6 %Chromat.
Stage #1: hydroxy-di-thiophen-2-yl-acetic acid methyl ester; scopine With sodium hydride In toluene; mineral oil at 70 - 90℃; under 225.023 - 300.03 Torr; for 4.25h; Inert atmosphere;
Stage #2: With hydrogenchloride In water; toluene; mineral oil Cooling with ice;
Stage #3: With sodium carbonate In water Overall yield = 1.01 g;
A 21%
B 35.7 %Chromat.
C 30.4 %Chromat.
2,2-diphenylpropionyl chloride
40997-78-2

2,2-diphenylpropionyl chloride

scopine
498-45-3

scopine

scopine 2,2-diphenylpropionate

scopine 2,2-diphenylpropionate

Conditions
ConditionsYield
In dichloromethane at 40℃; for 24h;47%
hydroxy-di-thiophen-2-yl-acetic acid methyl ester
26447-85-8

hydroxy-di-thiophen-2-yl-acetic acid methyl ester

scopine
498-45-3

scopine

A

N-demethyltiotropium
136310-64-0

N-demethyltiotropium

B

scopoline

scopoline

Conditions
ConditionsYield
Stage #1: hydroxy-di-thiophen-2-yl-acetic acid methyl ester; scopine With sodium t-butanolate In toluene at 70 - 90℃; under 225.023 - 300.03 Torr; for 4.25h; Inert atmosphere;
Stage #2: With hydrogenchloride In dichloromethane; water Cooling with ice;
Stage #3: With sodium carbonate In water Time; Concentration;
A 33%
B 26.3 %Chromat.
Stage #1: hydroxy-di-thiophen-2-yl-acetic acid methyl ester; scopine With sodium methylate In toluene at 70 - 90℃; under 75.0075 - 225.023 Torr; for 5.25h; Inert atmosphere;
Stage #2: With hydrogenchloride In water; toluene Cooling with ice;
Stage #3: With sodium carbonate In water
A 11.6 %Chromat.
B 57.3 %Chromat.
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

2-amino-5-fluorobiphenyl
1717-22-2

2-amino-5-fluorobiphenyl

scopine
498-45-3

scopine

(1R,2R,4S,5S,7s,9r)-7-(((5-fluorobiphenyl-2-yl)carbamoyl)oxy)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-ium chloride

(1R,2R,4S,5S,7s,9r)-7-(((5-fluorobiphenyl-2-yl)carbamoyl)oxy)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-ium chloride

Conditions
ConditionsYield
Stage #1: bis(trichloromethyl) carbonate; scopine In acetonitrile at 0 - 20℃; for 36h;
Stage #2: 2-amino-5-fluorobiphenyl With pyridine at 60℃; for 24h;
8%
1-chloro-4-(diazo(phenyl)methyl)benzene
1140-33-6

1-chloro-4-(diazo(phenyl)methyl)benzene

scopine
498-45-3

scopine

7t-(4-chloro-benzhydryloxy)-9-methyl-(1rN,2tH,4tH,5cN)-3-oxa-9-aza-tricyclo[3.3.1.02,4]nonane
116603-25-9

7t-(4-chloro-benzhydryloxy)-9-methyl-(1rN,2tH,4tH,5cN)-3-oxa-9-aza-tricyclo[3.3.1.02,4]nonane

Conditions
ConditionsYield
In benzene at 95 - 100℃; for 5.5h;
diazodiphenylmethane
908093-98-1

diazodiphenylmethane

scopine
498-45-3

scopine

7t-benzhydryloxy-9-methyl-(1rN,2tH,4tH,5cN)-3-oxa-9-aza-tricyclo[3.3.1.02,4]nonane
112018-04-9

7t-benzhydryloxy-9-methyl-(1rN,2tH,4tH,5cN)-3-oxa-9-aza-tricyclo[3.3.1.02,4]nonane

Conditions
ConditionsYield
In benzene at 80 - 85℃; for 3h;
3-acetoxy-2-phenyl-propionyl chloride
14510-37-3

3-acetoxy-2-phenyl-propionyl chloride

nitrobenzene
98-95-3

nitrobenzene

scopine
498-45-3

scopine

(+-)-O-acetyl-scopolamine hydrochloride

(+-)-O-acetyl-scopolamine hydrochloride

pyridine
110-86-1

pyridine

scopine
498-45-3

scopine

CrO3

CrO3

A

6exo,7exo-epoxy-tropan-3-one
498-47-5

6exo,7exo-epoxy-tropan-3-one

B

(+-)-N-formyl-norscopolin

(+-)-N-formyl-norscopolin

scopine
498-45-3

scopine

dl-scopolin

dl-scopolin

Conditions
ConditionsYield
bei der Destillation;
scopine
498-45-3

scopine

Cr2O3-H2SO4

Cr2O3-H2SO4

dl-scopolin

dl-scopolin

Conditions
ConditionsYield
at 50 - 60℃;
scopine
498-45-3

scopine

n KOH-solution

n KOH-solution

dl-scopolin

dl-scopolin

Conditions
ConditionsYield
at 20℃;
3-acetoxy-2-phenyl-propionyl chloride
14510-37-3

3-acetoxy-2-phenyl-propionyl chloride

nitrobenzene
98-95-3

nitrobenzene

scopine
498-45-3

scopine

O-<3-acetoxy-2-phenyl-propionyl>-scopolamine hydrochloride

O-<3-acetoxy-2-phenyl-propionyl>-scopolamine hydrochloride

3-acetoxy-2-phenyl-propionyl chloride
14510-37-3

3-acetoxy-2-phenyl-propionyl chloride

scopine
498-45-3

scopine

A

O-acetyl-scopine hydrochloride

O-acetyl-scopine hydrochloride

B

O-<3-acetoxy-2-phenyl>-propionyl>-scopolamine hydrochloride

O-<3-acetoxy-2-phenyl>-propionyl>-scopolamine hydrochloride

scopine
498-45-3

scopine

salts of scopolin

salts of scopolin

chlorosulfonic acid
7790-94-5

chlorosulfonic acid

scopine
498-45-3

scopine

A

scopinesulfuric acid

scopinesulfuric acid

B

dl-scopolinsulfuric acid

dl-scopolinsulfuric acid

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