64682-90-2

Upstream product

• 592-34-7 carbonochloridic acid, butyl ester 
• 95-55-6 2-amino-phenol 
• 871883-12-4 1-ethoxycarbonyloxy-2-butoxycarbonylamino-benzene 
• 109-65-9 1-bromo-butane 
• 124-38-9 carbon dioxide 
• 31020-13-0 1-butoxycarbonylamino-2-isobutoxycarbonyloxy-benzene 

Downstream Products

• 109395-15-5 [2-(2-piperidino-ethoxy)-phenyl]-carbamic acid butyl ester 
• 31020-13-0 1-butoxycarbonylamino-2-isobutoxycarbonyloxy-benzene 
• 83264-04-4 (2-Oxiranylmethoxy-phenyl)-carbamic acid butyl ester 
• 871883-12-4 1-ethoxycarbonyloxy-2-butoxycarbonylamino-benzene 
• 102417-11-8 [2-(2-Hydroxy-3-isopropylamino-propoxy)-phenyl]-carbamic acid butyl ester 
• 102417-12-9 [2-(3-tert-Butylamino-2-hydroxy-propoxy)-phenyl]-carbamic acid butyl ester 

Relevant academic research and scientific papers

Catalytic synthesis of benzimidazoles and organic carbamates using a polymer supported zinc catalyst through CO2 fixation

Utilization of carbon dioxide in chemical fixation for synthesis of fine chemicals like benzimidazoles, organic carbamates, etc. is in high demand in recent years as carbon dioxide is a cost effective, sustainable, and green renewable C1 source. In this article we present the design and synthesis of an organically modified polystyrene bound heterogeneous [PS-Zn(ii)-SALTETA] catalyst. The catalyst has been characterized thoroughly by Fourier transform infrared spectroscopy, atomic absorption spectroscopy, thermo gravimetric analysis, PXRD, SEM and EDAX studies. The catalyst was used for cyclization of o-phenylenediamines through insertion of carbon dioxide in order to produce benzimidazoles in the presence of dimethylamine borane (DMAB). The developed catalytic procedure is sustainable, economical and efficient owing to the utilization of ethanol/water as a biodegradable and environment friendly solvent system. Besides benzimidazole production the catalyst was also very active for manufacture of organic carbamates from anilines and n-butyl bromide under atmospheric CO2 pressure under solvent free conditions at room temperature and the catalytic protocol showed outstanding functional group tolerance. Moreover the catalyst is highly recyclable and reusable.

Synthesis and structure-activity relationships of new β-adrenoreceptor antagonists. Evidence for the electrostatic requirements for β-adrenoreceptor antagonists

A series of mono- and disubstituted phenoxypropanolamines, structurally related to practolol and acebutolol, has been synthesized and tested for β-adrenoreceptor blocking activity. Structure-activity relationships are discussed. The reasons for the lack of activity of compounds 3n and 4n have also been examined. The results suggest that the negative electrostatic potential above the phenyl ring of phenoxypropanolamines is essential for binding activity and point to the presence of an electropositive residue in the β-adrenoreceptor binding site.