64686-61-9Relevant academic research and scientific papers
A chiral cobalt(II) complex catalyzed asymmetric formal [3+2] cycloaddition for the synthesis of 1,2,4-triazolines
Ma, Baiwei,Luo, Weiwei,Lin, Lili,Liu, Xiaohua,Feng, Xiaoming
, p. 4077 - 4079 (2017/04/13)
A highly efficient catalytic asymmetric formal [3+2] cycloaddition reaction of 5-alkoxyoxazoles with azodicarboxylate compounds has been realized by a chiral N,N′-dioxide/Co(BF4)2·6H2O complex. A series of poly-substituted 1,2,4-triazolines compounds were obtained in moderate to excellent yields (70-99%) with excellent enantioselectivities (82-98% ee).
Preparation of substituted oxazoles by ritter reactions of α-oxo tosylates
Lai, Ping-Shan,Taylor, Mark S.
experimental part, p. 1449 - 1452 (2010/09/14)
The Lewis acid catalyzed Ritter reaction of α-oxo tosylates with nitriles forms the basis of an efficient synthesis of oxazoles. Oxazoles with various substituents can be readily prepared from inexpensive starting materials. Georg Thieme Verlag Stuttgart.
