75097-32-4

Usage

Uses

Used in Pharmaceutical Industry:
(2-bromo-5-methoxy-4-methylphenyl)acetic acid is used as a pharmaceutical intermediate for the development of new drugs, leveraging its unique structural features and potential biological activities to target specific therapeutic areas.
Used in Organic Synthesis:
(2-bromo-5-methoxy-4-methylphenyl)acetic acid is used as a building block in organic synthesis to create more complex compounds, contributing to the advancement of chemical research and the development of novel materials and pharmaceuticals.

Upstream product

• 57335-02-1 2-bromo-5-methoxy-4-methylphenylacetonitrile 
• 64829-31-8 2-(3-methoxy-4-methylphenyl)acetonitrile 
• 100861-38-9 (3-methoxy-4-methylphenyl)acetic acid 
• 4685-50-1 3-methoxy-4-methylbenzyl alcohol 
• 24973-22-6 3-methoxy-4-methylbenzaldehyde 
• 57295-30-4 3-hydroxy-4-methylbenzaldehyde 

Downstream Products

• 75156-86-4 methyl α-<3-acetoxy-4-(N-ethoxycarbonyl-N-methylamino)-pyrrolidin-2-ylidene>-α-(2-bromo-5-methoxy-4-methoxymethylphenyl)-acetate 
• 1232402-52-6 (2-bromo-5-methoxy-4-methyl-phenyl)-acetic acid chloride 
• 75097-34-6 benzyl (Z)-α-<3-acetoxy-4-(N-ethoxycarbonyl-N-methylamino)pyrrolidin-2-ylidene>-α-(2-bromo-5-methoxy-4-methylphenyl)acetate 
• 75097-35-7 (+/-)-benzyl 1α-acetoxy-2β-(N-ethoxycarbonyl-N-methylamino)2,3-dihydro-7-methoxy-6-methyl-1H-pyrrolo<1,2-a>indole-9-carboxylate 
• 75097-36-8 benzyl 2, 3, 3a, 4, 10a, 10b-hexahydro-8-methoxy-3,7,-dimethyl-2-oxo-10H-oxazolo<4', 5'-3, 4>pyrrolo<1,2-a>indole-10-carboxylate 
• 75156-81-9 methyl α-bromo-(2-bromo-5-methoxy-4-methylphenyl)acetate 
• 75156-82-0 methyl α-bromo-(2-bromo-5-methoxy-4-methoxymethylphenyl)acetate 

Relevant academic research and scientific papers

DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS

Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, R1, R2, R3, R4 and R5 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.

Studies on the Synthesis of Heterocyclic Compounds. Part 832. A Simple and Efficient Synthesis of Apomitomycin Derivatives; a Potential Intermediate for Mitomycin Synthesis

Condensation of pyrrolidine-2-thione (21) with methyl α-bromo-(2-bromo-4,5-dimethoxyphenyl)acetate (15) gave methyl (Z)-α-(2-bromo-4,5-dimethoxyphenyl)-α-pyrrolidin-2-ylideneacetate (25) in high yield.Several other methyl (Z)-α-aryl-α-acetates (26)-(31) were also synthesised in good yields from reaction of the corresponding phenylacetates (15), (12), and (13) with trans-3-acetoxy-4-(N-ethoxycarbonyl-N-methylamino)pyrrolidine-2-thione (20).Treatment of compounds (25)-(31) with sodium hydride and copper(I) bromide in dimethylformamide afforded methyl 2,3-dihydro-6,7-dimethoxy-1H-pyrroloindole-9-carboxylate (34) and the methyl (+/-)-trans-1-acetoxy-2-(N-ethoxycarbonyl-N-methylamino)-2,3-dihydro-1H-pyrroloindole-9-carboxylates (35)-(37) in good yields.Methyl (+/-)-trans-1-acethoxy-2-(N-ethoxycarbonyl-N-methylamino)-2,3-dihydro-7-methoxy-6-methyl-1H-pyrroloindole-9-carboxylate (36) was converted into the 5,8-quinone (3), via the 8-nitro-compound (38).