6485-59-2

Upstream product

• 151-50-8 potassium cyanide 
• 124984-84-5 N-<1-(benzotriazol-1-yl)-1-phenylmethyl>-p-toluenesulfonamide 
• 98-59-9 p-toluenesulfonyl chloride 
• 7677-24-9 trimethylsilyl cyanide 
• 51608-60-7 phenyl N-tosyl imine 
• 51608-60-7 N-(benzylidene)-p-methylbenzenesulfonamide 
• 70-55-3 toluene-4-sulfonamide 
• 623-49-4 ethyl cyanoformate 
• 100-52-7 benzaldehyde 
• 613-90-1 benzoyl cyanide 
• 52962-78-4 4-methyl-N-(phenyl(phenylsulfonyl)methyl)benzenesulfonamide 
• 98-88-4 benzoyl chloride 
• 1576-37-0 N-benzyl-p-toluenesulfonamide 

Downstream Products

• 1384465-78-4 (+/-)-2-phenyl-1-tosylazetidine-2-carbonitrile 

Relevant academic research and scientific papers

Dimethylsulfoxide-promoted Strecker reaction of N-tosylaldimines with cyanoformate

A metal-free method for performing the Strecker reaction of N-tosylaldimines with ethyl cyanoformate in dimethylsulf-oxide (DMSO) has been developed. Various types of N-tosyl-aldimines undergo the cyanation to provide the N-protected -amino nitriles. This

Continuous solid solutions constructed from two isostructural octahedron-based molecular sieves: preparation, acidity regulation and catalytic application in Strecker reactions

Strecker reactions have an important application in the preparation of α-amino acids and biologically active molecules in homogeneous acid- or base-catalyzed systems. As novel solid acid catalysts, AlxGa1-x-PKU-1 (x = 0-1) solid solu

Verkade's Superbase as an Organocatalyst for the Strecker Reaction

Proazaphosphatranes -Verkade's superbases- proved to be efficient organocatalysts for the Strecker reaction between protected imines and trimethylsilyl cyanide (TMSCN). Excellent to quantitative yields were reached and, compared to other systems, only low

Octahedron-based redox molecular sieves M-PKU-1 (M?=?Cr, Fe): A novel dual-centered solid acid catalyst for heterogeneously catalyzed Strecker reaction

Cr-PKU-1, an octahedron-based redox molecular sieve, was found to be an efficient, environmentally benign and easily recoverable catalyst for the heterogeneously-catalyzed Strecker reaction under the mild conditions. This material was evidenced to be a du

Nitroxyl-Radical-Catalyzed Oxidative Coupling of Amides with Silylated Nucleophiles through N-Halogenation

A nitroxyl-radical-catalyzed oxidative coupling reaction between amines with an N-protecting electron-withdrawing group (EWG) and silylated nucleophiles was developed to furnish coupling products in high yields, thus opening up new frontiers in organocatalyzed reactions. This reaction proceeded through the activation of N-halogenated amides by a nitroxyl-radical catalyst, followed by carbon–carbon coupling with silylated nucleophiles. Studies of the reaction mechanism indicated that the nitroxyl radical activates N-halogenated amides, which are generated from N-EWG-protected amides and a halogenation reagent, to give the corresponding imines.

Mechanochemical Strecker Reaction: Access to α-Aminonitriles and Tetrahydroisoquinolines under Ball-Milling Conditions

A mechanochemical version of the Strecker reaction for the synthesis of α-aminonitriles was developed. The milling of aldehydes, amines, and potassium cyanide in the presence of SiO2gave the corresponding α-aminonitriles in good to high yields. The high efficiency of the mechanochemical Strecker-type multicomponent reaction allowed the one-pot synthesis of tetrahydroisoquinolines after a subsequent internal N-alkylation reaction.

Octahedra-based molecular sieve aluminoborate (PKU-1) as solid acid for heterogeneously catalyzed Strecker reaction

An aluminoborate (PKU-1) with octahedron-based framework was found to be a highly efficient solid acid catalyst for the rapid and convenient synthesis of α-aminonitriles from imines and TMSCN under mild reaction conditions. The catalytic active sites are

Conversion of N-benzyloxycarbonylamino- and N-Tosylamino-benzyl phenylsulfones by green Strecker reactions to α-aminobenzyl nitriles using potassium hexacyanoferrate(II)

The cyanation of aldimines, generated in situ from N- benzyloxycarbonylamino- and N-tosylamino-benzyl phenylsulfones, to the corresponding N-protected a-aminobenzyl nitriles has been achieved by eco-friendly Strecker reactions using potassium hexacyanofer

Small molecule as a chiral organocatalyst for asymmetric strecker reaction

A simple and novel chiral amide-based organocatalyst 6 was synthesized from readily available starting materials for the asymmetric Strecker reaction. A variety of N-benzhydryl- and N-tosyl-substituted imines were found to be suitable substrates with i-Pr

Hydrocyanation of sulfonylimines using potassium hexacyanoferrate(II) as an eco-friendly cyanide source

An efficient and eco-friendly method for hydrocyanation of sulfonylimines via one-pot two-step procedure using potassium hexacyanoferrate(II) as a cyanide source, benzoyl chloride as a promoter, and potassium carbonate as a base is described. This protocol has the features of using nontoxic, nonvolatile and inexpensive cyanide source, high yield, and simple work-up procedure.