64853-54-9

Upstream product

• 1646-53-3 bromodurene 
• 75-36-5 acetyl chloride 
• 506-96-7 Acetyl bromide 

Downstream Products

• 64853-57-2 2,3,5,6-Tetramethyl-4-cyclohexylthio-acetophenon 
• 64853-61-8 2,3,5,6-Tetramethyl-4-bromphenyl-glyoxal-hydrat 
• 64853-66-3 2,3,5,6-Tetramethyl-4-S-cyclohexyl-phenyl-glyoxal-hydrat 
• 64853-92-5 1-(4-Cyclohexylsulfanyl-2,3,5,6-tetramethyl-phenyl)-2-{(E)-2-[2-(4-cyclohexylsulfanyl-2,3,5,6-tetramethyl-phenyl)-2-oxo-eth-(E)-ylideneamino]-phenylimino}-ethanone 
• 64853-74-3 4-[2-(4-Cyclohexylsulfanyl-2,3,5,6-tetramethyl-phenyl)-1-ethoxy-2-oxo-ethylamino]-benzoic acid 
• 64853-89-0 1-(4-Bromo-2,3,5,6-tetramethyl-phenyl)-2-{(E)-2-[2-(4-bromo-2,3,5,6-tetramethyl-phenyl)-2-oxo-eth-(E)-ylideneamino]-phenylimino}-ethanone 
• 64853-70-9 4-[2-(4-Bromo-2,3,5,6-tetramethyl-phenyl)-1-ethoxy-2-oxo-ethylamino]-benzoic acid 

Relevant academic research and scientific papers

Transition metal free α-C-alkylation of ketones using secondary alcohols

A base-mediated α-C-alkylation of ketones with secondary alcohols has been developed. This transition metal free approach employs KOt-Bu as the base and exhibits a broad scope, allowing a range of commodity aliphatic secondary alcohols and 1-arylethanols

Hydrogen Borrowing Catalysis with Secondary Alcohols: A New Route for the Generation of β-Branched Carbonyl Compounds

A hydrogen borrowing reaction employing secondary alcohols and Ph? (Me5C6) ketones to give β-branched carbonyl products is described (21 examples). This new C-C bond forming process requires low loadings of [Cp?IrCl2]2, relatively low temperatures, and up to 2.0 equiv of the secondary alcohol. Substrate-induced diastereoselectivity was observed, and this represents the first example of a diastereoselective enolate hydrogen borrowing alkylation. By utilizing the Ph? group, the β-branched products could be straightforwardly cleaved to the corresponding esters or amides using a retro-Friedel-Crafts reaction. Finally, this protocol was applied to the synthesis of fragrance compound (±)-3-methyl-5-phenylpentanol.