64879-76-1

Upstream product

• 186581-53-3 diazomethane 
• 5697-44-9 p-tolylsulfonylmethyl isocyanide 
• 1617-17-0 2-chlorpropionitrile 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 77597-94-5 2-((R)-Toluene-4-sulfinyl)-propionitrile 
• 74-88-4 methyl iodide 
• 67-56-1 methanol 
• 60-29-7 diethyl ether 
• 1517-82-4 (1R,2S,5R,SS)-(-)-menthyl p-toluenesulfinate 

Downstream Products

• 67274-97-9 2,3-dimethyl-3-nitro-2-tosylbutanenitrile 
• 67319-37-3 2-(1-Nitro-cyclohexyl)-2-(toluene-4-sulfonyl)-propionitrile 
• 67274-99-1 2-(1-Nitro-cyclopentyl)-2-(toluene-4-sulfonyl)-propionitrile 

Relevant academic research and scientific papers

Copper-Catalyzed Cross-Nucleophile Coupling of β-Allenyl Silanes with Tertiary C-H Bonds: A Radical Approach to Branched 1,3-Dienes

Described herein is a distinctive approach to branched 1,3-dienes through oxidative coupling of two nucleophilic substrates, β-allenyl silanes, and hydrocarbons appending latent functionality by copper catalysis. Notably, C(sp3)-H dienylation proceeded in a regiospecific manner, even in the presence of competitive C-H bonds that are capable of occurring hydrogen atom transfer process, such as those located at benzylic and other tertiary sites, or adjacent to an oxygen atom. Control experiments support the intermediacy of functionalized alkyl radicals.

Straightforward construction of diarylmethane skeletons via aryne insertion into carbon-carbon σ-bonds

Two molar amounts of arynes were found to couple with nitriles via carbon-carbon σ-bond cleavage, assembling diverse diarylmethane skeletons in a straightforward manner. The Royal Society of Chemistry.

Synthesis and Stereomutation of Optically Active α-Cyanosulphoxides

Reaction of (-)-menthyl (S)-toluene-p-sulphinate with nitriles and lithium NN-di-isopropylamide (LDA) in 1:1:1 and 1:2:1 ratios affords optically active α-cyano- and α-cyano-β-imino-sulphoxides, respectively. α-Cyanobenzyl sulphoxide racemizes through a h