65003-32-9

Basic information

• Product Name: [5-[(Piperidin-1-yl)carbonyl]-1H-benzimidazol-2-yl]carbamic acid methyl ester
• Synonyms: [5-[(Piperidin-1-yl)carbonyl]-1H-benzimidazol-2-yl]carbamic acid methyl ester
• CAS NO: 65003-32-9
• Molecular Formula: C15H18N4O3
• Molecular Weight: 302.33
• Mol File: 65003-32-9.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Density: 1.376g/cm³
• Refractive Index: 1.676
• CAS DataBase Reference: [5-[(Piperidin-1-yl)carbonyl]-1H-benzimidazol-2-yl]carbamic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [5-[(Piperidin-1-yl)carbonyl]-1H-benzimidazol-2-yl]carbamic acid methyl ester(65003-32-9)
• EPA Substance Registry System: [5-[(Piperidin-1-yl)carbonyl]-1H-benzimidazol-2-yl]carbamic acid methyl ester(65003-32-9)

Safety Data

• Hazardous Substances Data: 65003-32-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C15H18N4O3/c1-22-15(21)18-14-16-11-6-5-10(9-12(11)17-14)13(20)19-7-3-2-4-8-19/h5-6,9H,2-4,7-8H2,1H3,(H2,16,17,18,21)

Upstream product

• 24170-23-8 3-nitro-4-acetylaminobenzoyl chloride 
• 110-89-4 piperidine 
• 135696-94-5 methyl 5-chlorocarbonyl-1H-benzimidazole-2-carbamate 
• 556-08-1 p-(acetylamino)benzoic acid 
• 1539-06-6 3-nitro-4-acetamidobenzoic acid 
• 867-44-7 S-Methylisothiourea sulfate 
• 79-22-1 methyl chloroformate 
• 89791-06-0 (3,4-diaminophenyl)(piperidin-1-yl)methanone 
• 89790-64-7 2'-Nitro-4'-piperidinocarbamoylacetanilid 
• 89790-85-2 (4-Amino-3-nitro-phenyl)-piperidin-1-yl-methanone 

Relevant articles and documents

Synthesis and in vitro cysticidal activity of new benzimidazole derivatives

Despite albendazole being the drug of choice in neurocysticercosis treatment, its low solubility limits its bioavailability; therefore, more research is required in order to find new molecules with cestocidal activity and adequate aqueous solubility. A set of 13 benzimidazole derivatives were synthesized and their in vitro activities were evaluated against Taenia crassiceps cysts, using albendazole sulfoxide as reference molecule, showing that two of them exhibited good activity. Molecular modelling revealed that the cysticidal efficacy depends on the presence on the molecule of an H in the 1-position, a planar carbamate group at 2-position, and if the substituent in 5-position is voluminous, it should be orthogonal to the benzimidazole ring.