65004-23-1Relevant academic research and scientific papers
Excited-state acidity of bifunctional compounds: Part 5 5-(2-hydroxyphenyl)-3-phenyl-1,2,4-oxadiazole and 3-(2-hydroxyphenyl)-5-phenyl-1,2,4-oxadiazole
Carvalho, Carlos,Brinn, Ira,Baumann, Wolfram,Reis, Heribert,Nagy, Zsolt
, p. 3325 - 3329 (1997)
Fluorescence emission and excitation spectra and experimental dipole moments are presented for 5-(2-hydroxyphenyl)-3-phenyl-1,2,4-oxadiazole and 3-(2-hydroxyphenyl)-5-phenyl-1,2,4-oxadiazole. These data indicate that the long-wavelength emission of the fo
Copper-Catalyzed Three-Component Cascade Reaction of Benzaldehyde with Benzylamine and Hydroxylamine or Aniline: Synthesis of 1,2,4-Oxadiazoles and Quinazolines
Wang, Chao,Rui, Xiyan,Si, Dongjuan,Dai, Rupeng,Zhu, Yueyue,Wen, Hongmei,Li, Wei,Liu, Jian
supporting information, p. 2825 - 2833 (2021/04/26)
The analogous three-component synthesis strategy for substituted 1,2,4-oxadiazole and quinazoline derivatives from readily available benzaldehyde, benzylamine and hydroxylamine or aniline has been developed. Both the cascade reaction sequences involves nucleophilic addition of C?N bond, introduction a halogen donor, nucleophilic substitution and Cu(II)-catalyzed aerobic oxidation. This synthesis methodology demonstrated good yields, broad substrate scope and oxygen as a green oxidant. Thus, this synthesis protocol provides strategies for the construction of substituted 1,2,4-oxadiazole and quinazolines from readily and simple starting materials. (Figure presented.).
The role of the hydrogen bonding in cycloadditions of benzonitrile oxide with cyanophenols
Corsaro, Antonino,Buemi, Giuseppe,Chiacchio, Ugo,Perrini, Giancarlo,Pistara, Venerando,Romeo, Roberto
, p. 7885 - 7892 (2007/10/03)
The reactivity of aromatic nitriles in cycloadditions with benzonitrile oxide is remarkably enhanced by the ortho-hydroxy substituent. Semiempirical PM3 calculations are in agreement with a hydrogen bonding effect.
SYNTHESIS AND STUDY OF THE STRUCTURE OF o-HYDROXYARYL-1,2,4-OXADIAZOLES
Ryabukhin, Yu. I.,Eliseeva, A. Yu.,Suzdalev, K. F.,Bulgarevich, S. B.,Movshovich, D. Ya.,et al.
, p. 454 - 463 (2007/10/02)
The reaction of 4-oxo-1,3-benz- and naphthoxazinium perchlorates with hydroxylamine leads to 5-(-o-hydroxyaryl)-1,2,4-oxadiazoles rather than to 3-(o-hydroxyaryl)-1,2,4-oxadiazoles, as was previously assumed.The structure of the compounds obtained was pro
