65016-21-9Relevant academic research and scientific papers
A novel zinc-catalyzed Suzuki-type cross-coupling reaction of aryl boronic acids with alkynyl bromides
Keerthi Krishnan,Saranya, Salim,Rohit,Anilkumar, Gopinathan
, p. 266 - 271 (2019/03/26)
A novel Suzuki-type cross-coupling reaction of organoboron reagents with alkynyl bromides has been developed in the presence of catalytic Et2Zn/DMEDA system. The reaction afforded a variety of internal alkynes in moderate to excellent yields under mild reaction conditions without the formation of any homo-coupling products. The resulting internal alkynes have valuable applications in pharmaceutical and industrial areas. The use of relatively non-toxic zinc, chelating amine ligand and low reaction temperature make this protocol an alternative for the synthesis of internal alkynes. The scope and limitations of this protocol are also investigated.
Cross-coupling reactivity of 1,1-dichloroalkenes under palladium catalysis: Domino synthesis of diarylalkynes
Maddali, L. N. Rao,Meka, Suresh
supporting information, p. 4412 - 4418 (2018/03/21)
An efficient synthesis of diarylalkynes was achieved from the domino cross-coupling reaction of 1,1-dichloroalkenes with triarylbismuth reagents under palladium-catalyzed conditions. Under the established palladium protocol, 1,1-dichloroalkenes demonstrated hitherto unknown remarkable cross-coupling reactivity with organometallic triarylbismuth reagents to furnish functionalized diarylalkynes.
Palladium-Catalyzed Desulfitative Cross-Coupling of Arylsulfonyl Hydrazides with Terminal Alkynes: A General Approach toward Functionalized Internal Alkynes
Qian, Liang-Wei,Sun, Mengli,Dong, Jianyu,Xu, Qing,Zhou, Yongbo,Yin, Shuang-Feng
supporting information, p. 6764 - 6769 (2017/07/15)
A palladium-catalyzed Sonogashira-type coupling between arylsulfonyl hydrazides and terminal alkynes via Ar(C)-S bond cleavage is disclosed, which enables the general synthesis of functionalized internal alkynes, especially the Br-substituted ones, in good to excellent yields under acid- and base-free conditions.
Copper-catalyzed synthesis of internal alkynes via domino coupling between 1,1-dihalo-1-alkenes and arylboronic acids
Yan, Hong,Lu, Linhua,Sun, Peng,Zhu, Yan,Yang, Hailong,Liu, Defu,Rong, Guangwei,Mao, Jincheng
, p. 377 - 381 (2013/04/10)
We have developed the practical copper-catalyzed formation of various internal alkynes via domino couplings between 1,1-dihalo-1-alkenes and arylboronic acids in the presence of low-cost 8-hydroxylquinoline as the ligand.
An efficient protocol for copper-free palladium-catalyzed Sonogashira cross-coupling in aqueous media at low temperatures
Marziale, Alexander N.,Schlüter, Johannes,Eppinger, J?rg
supporting information; experimental part, p. 6355 - 6358 (2011/12/22)
A thorough study on copper-free Sonogashira cross-couplings in water was carried out using the palla-dacycle, [{Pd(μ-Cl){K2-P,C-P(iPr) 2(OC6H3-2-Ph)}}2] as pre-catalyst with different bases and palladium concentrations. The highly active pre-catalyst imparts good to near quantitative yields using a concentration of 0.25 mol % at 40 °C. This broadly applicable protocol exhibits high tolerance of functional groups and substitution patterns.
Ligand-free copper oxide nanoparticle-catalyzed sonogashira coupling reaction
Yuan, Yu,Zhu, Haitao,Zhao, Dongbo,Zhang, Li
experimental part, p. 1792 - 1798 (2011/07/08)
The catalytic Sonogashira coupling reaction of terminal alkynes and aryl halides is developed using copper(II) oxide nanoparticles as catalyst in dimethyl sulfoxide. The procedure is experimentally simple, general, efficient, and free from addition of ext
