65023-81-6

Upstream product

• 74988-42-4 3-Phenyl-3H-benzo[4,5]furo[3,2-d]pyrimidin-4-ylideneamine 
• 62208-67-7 3-amino[1]benzofuran-2-carbonitrile 
• 611-20-1 salicylonitrile 
• 74988-37-7 3-(Ethoxymethylene)amino-2-benzofurancarbonitrile 
• 39876-88-5 4-Chlorobenzofuro<3,2-d>pyrimidine 
• 62-53-3 aniline 

Relevant academic research and scientific papers

Efficient new synthesis of N-arylbenzo[b]furo[3,2-d]pyrimidin-4-amines and their benzo[b]thieno[3,2-d]pyrimidin-4-amine analogues via a microwave-assisted Dimroth rearrangement

A useful and rapid access to libraries of N-arylbenzo[b]furo[3,2-d] pyrimidin-4-amines (1) and their novel benzo[b]thieno[3,2-d]pyrimidin-4-amine analogues (2) was investigated for the first time. Title compounds were obtained via microwave-accelerated co

Dimroth Rearrangement and Other Investigations on Benzofuropyrimidines

Synthesis of 3-alkyl- and 3-aryl-3,4-dihydro-4-iminobenzofuropyrimidines (IV-IX) by the reaction of 3-(ethoxymethylene)amino-2-benzofurancarbonitrile (II) with alkyl- and aryl-amines, and their Dimroth type rearrangement to 4-alkyl- and 4-aryl-aminobenzofuropyrimidines (X-XIV) are described.The reactions of II with ammonia and hydrazine hydrate giving 4-aminobenzofuropyrimidine (III) and 3-amino-4-imino-3,4-dihydrobenzofuropyrimidine (XV) respectively have been investigated.Conversion of XV into s-triazolopyrimidobenzofuran (XVI) and 3-amino-2-benzofurancarbonitrile (I) into various 2-alkyl-4-alkoxybenzofuropyrimidines (XVII-XX) is also reported.