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65043-22-3

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65043-22-3 Usage

Description

Indeloxazine hydrochloride is a nootropic indicated for the treatment of senile dementia. In animal models indeloxazine reportedly enhances brain energy metabolism and monoamine content; its claimed protective effect on ischemia-induced amnesia is supported by the prolonged step-through latency in passive avoidance tests.

Originator

Yamanouchi (Japan)

Uses

Antidepressant.

Brand name

Elen

Metabolic pathway

After oral administration of indeloxazine hydrochloride to rats, two conjugates, which are labile to a- glucosidase hydrolysis but refractory to b-glucosidase, are isolated from the urine and identified as a-D- glucopyranosides of trans-4-(2-morpholinylmethoxy)- 1,2-indandiol and trans-6-[[(1,2-dihydroxy-4- indanyl)oxy]-methyl]-3-morpholinone.

Check Digit Verification of cas no

The CAS Registry Mumber 65043-22-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,5,0,4 and 3 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 65043-22:
(7*6)+(6*5)+(5*0)+(4*4)+(3*3)+(2*2)+(1*2)=103
103 % 10 = 3
So 65043-22-3 is a valid CAS Registry Number.
InChI:InChI=1/C14H17NO2.ClH/c1-3-11-4-2-6-14(13(11)5-1)17-10-12-9-15-7-8-16-12;/h1-4,6,12,15H,5,7-10H2;1H

65043-22-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(((1H-Inden-7-yl)oxy)methyl)morpholine hydrochloride

1.2 Other means of identification

Product number -
Other names 2-(3H-inden-4-yloxymethyl)morpholine,hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:65043-22-3 SDS

65043-22-3Synthetic route

(+/-)-2-<(1-hydoxyindan-4-yloxy)methyl>-4-triphenylmethylmorpholine
64966-73-0

(+/-)-2-<(1-hydoxyindan-4-yloxy)methyl>-4-triphenylmethylmorpholine

2-(7-indenyloxymethyl)-morpholine hydrochloride
65043-22-3

2-(7-indenyloxymethyl)-morpholine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In ethanol for 17h; Heating;73.4%
sulfuric acid mono-(2-amino-ethyl ester)
926-39-6

sulfuric acid mono-(2-amino-ethyl ester)

1-(inden-7-yloxy)-2,3-epoxypropane
30190-85-3

1-(inden-7-yloxy)-2,3-epoxypropane

2-(7-indenyloxymethyl)-morpholine hydrochloride
65043-22-3

2-(7-indenyloxymethyl)-morpholine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; sodium hydroxide In methanol 1.) 55 deg C, 16 h; 2.) iso-PrOH, acetone, 0-5 deg C, 15 min.;73%
(+/-)-2-<(1-oxoindan-4-yloxy)methyl>-4-triphenylmethylmorpholine
60929-58-0

(+/-)-2-<(1-oxoindan-4-yloxy)methyl>-4-triphenylmethylmorpholine

2-(7-indenyloxymethyl)-morpholine hydrochloride
65043-22-3

2-(7-indenyloxymethyl)-morpholine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 77.7 percent / LiAlH4 / tetrahydrofuran / 3 h / Ambient temperature
2: 73.4 percent / 0.5 N HCl / ethanol / 17 h / Heating
View Scheme
R,S-2-hydroxymethyl-4-benzylmorpholine
40987-24-4

R,S-2-hydroxymethyl-4-benzylmorpholine

2-(7-indenyloxymethyl)-morpholine hydrochloride
65043-22-3

2-(7-indenyloxymethyl)-morpholine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 95 percent / H2 / 10percent Pd-C / methanol / Ambient temperature
2: 96.4 percent / Et3N / CH2Cl2 / 10 h / Ambient temperature
3: 70 percent / pyridine / CH2Cl2 / 15 h / Ambient temperature
4: 73.5 percent / dimethylformamide / 17 h / 100 - 105 °C
5: 77.7 percent / LiAlH4 / tetrahydrofuran / 3 h / Ambient temperature
6: 73.4 percent / 0.5 N HCl / ethanol / 17 h / Heating
View Scheme
morpholin-2-ylmethanol
103003-01-6

morpholin-2-ylmethanol

2-(7-indenyloxymethyl)-morpholine hydrochloride
65043-22-3

2-(7-indenyloxymethyl)-morpholine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 96.4 percent / Et3N / CH2Cl2 / 10 h / Ambient temperature
2: 70 percent / pyridine / CH2Cl2 / 15 h / Ambient temperature
3: 73.5 percent / dimethylformamide / 17 h / 100 - 105 °C
4: 77.7 percent / LiAlH4 / tetrahydrofuran / 3 h / Ambient temperature
5: 73.4 percent / 0.5 N HCl / ethanol / 17 h / Heating
View Scheme
(+/)-2-hydroxymethyl-4-triphenylmethylmorpholine
131965-77-0

(+/)-2-hydroxymethyl-4-triphenylmethylmorpholine

2-(7-indenyloxymethyl)-morpholine hydrochloride
65043-22-3

2-(7-indenyloxymethyl)-morpholine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 70 percent / pyridine / CH2Cl2 / 15 h / Ambient temperature
2: 73.5 percent / dimethylformamide / 17 h / 100 - 105 °C
3: 77.7 percent / LiAlH4 / tetrahydrofuran / 3 h / Ambient temperature
4: 73.4 percent / 0.5 N HCl / ethanol / 17 h / Heating
View Scheme
2-(p-toluenesulfonyloxymethyl)-4-triphenylmethylmorpholine
60929-57-9

2-(p-toluenesulfonyloxymethyl)-4-triphenylmethylmorpholine

2-(7-indenyloxymethyl)-morpholine hydrochloride
65043-22-3

2-(7-indenyloxymethyl)-morpholine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 73.5 percent / dimethylformamide / 17 h / 100 - 105 °C
2: 77.7 percent / LiAlH4 / tetrahydrofuran / 3 h / Ambient temperature
3: 73.4 percent / 0.5 N HCl / ethanol / 17 h / Heating
View Scheme
4-morpholin-2-ylmethoxy-indan-1-ol
60929-60-4

4-morpholin-2-ylmethoxy-indan-1-ol

2-(7-indenyloxymethyl)-morpholine hydrochloride
65043-22-3

2-(7-indenyloxymethyl)-morpholine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; sodium chloride In ethanol; chloroform; acetone
2-(7-indenyloxymethyl)-morpholine hydrochloride
65043-22-3

2-(7-indenyloxymethyl)-morpholine hydrochloride

(+)-indeloxazine hydrochloride, (+)-YM-08054 hydrochloride
65043-22-3, 76489-35-5, 104908-10-3, 104908-43-2

(+)-indeloxazine hydrochloride, (+)-YM-08054 hydrochloride

Conditions
ConditionsYield
Yield given;
2-(7-indenyloxymethyl)-morpholine hydrochloride
65043-22-3

2-(7-indenyloxymethyl)-morpholine hydrochloride

(-)-indeloxazine hydrochloride; (-)-YM-08054 hydrochloride
65043-22-3, 76489-35-5, 104908-10-3, 104908-43-2

(-)-indeloxazine hydrochloride; (-)-YM-08054 hydrochloride

Conditions
ConditionsYield
Yield given;

65043-22-3Relevant articles and documents

Syntheses of (±)-2-[(inden-7-yloxy)methyl]morpholine hydrochloride (YM-08054, indeloxazine hydrochloride) and its derivatives with potential cerebral-activating and antidepressive properties

Kojima,Niigata,Fujikura,et al.

, p. 3766 - 3774 (2007/10/02)

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