65078-75-3

Basic information

• Product Name: N-(2,4-dichloro-6-nitro-phenyl)acetamide
• Synonyms: N-(2,4-dichloro-6-nitro-phenyl)acetamide
• CAS NO: 65078-75-3
• Molecular Formula: C₈H₆Cl₂N₂O₃
• Molecular Weight: 249.05
• Mol File: 65078-75-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 400.8°C at 760 mmHg
• Flash Point: 196.2°C
• Appearance: /
• Density: 1.573g/cm³
• Vapor Pressure: 1.24E-06mmHg at 25°C
• Refractive Index: 1.637
• CAS DataBase Reference: N-(2,4-dichloro-6-nitro-phenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,4-dichloro-6-nitro-phenyl)acetamide(65078-75-3)
• EPA Substance Registry System: N-(2,4-dichloro-6-nitro-phenyl)acetamide(65078-75-3)

Safety Data

• Hazardous Substances Data: 65078-75-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H6Cl2N2O3/c1-4(13)11-8-6(10)2-5(9)3-7(8)12(14)15/h2-3H,1H3,(H,11,13)

Upstream product

• 552-32-9 o-nitroacetanilide 
• 88-74-4 2-nitro-aniline 
• 103-84-4 Acetanilid 
• 108-24-7 acetic anhydride 
• 2683-43-4 2,4-dichloro-6-nitroaniline 
• 554-00-7 2,4-Dichloroaniline 
• 6975-29-7 N-(2,4-dichlorophenyl)acetamide 

Downstream Products

• 113001-08-4 N-(2,4-Dichloro-6-{[1-(2-nitro-phenyl)-meth-(Z)-ylidene]-amino}-phenyl)-acetamide 
• 113001-00-6 2-amino-4,6-dichloroacetanilide 
• 2683-43-4 2,4-dichloro-6-nitroaniline 

Relevant articles and documents

Activator free, expeditious and eco-friendly chlorination of activated arenes by N-chloro-N-(phenylsulfonyl)benzene sulfonamide (NCBSI)

N-Chloro-N-(phenylsulfonyl)benzene sulfonamide (NCBSI) has been explored for the first time as a chlorinating reagent for direct chlorination of various activated arenes and heterocycles without any activator. A comparative in-silico study was performed to determine the electrophilic character for NCBSI and commercially available N-chloro reagents to reveal the reactivity on a theoretical viewpoint. The reagent was prepared by an improved method avoiding the use of hazardous t-butyl hypochlorite. This reagent was proved to be very reactive compared to other N-chloro reagents. The precursor of the reagent N-(phenylsulfonyl)benzene sulfonamide was recovered from aqueous spent, which can be recycled to synthesize NCBSI. The eco-friendly protocol was equally applicable for the synthesis of industrially important chloroxylenol as an antibacterial agent.

The electrophilic substitution of some 2,4- and 2,6- dihaloacetanilides

The orientation of electrophilic substitution of some 2,4- and 2,6-dihaloacetanilides has been examined by NMR methods. Mixed acid nitration of 2,6-dichloro and 2-chloro-6-methylacetanilides gave predominantly the 3-nitro derivatives.