65082-45-3

Usage

Appearance

White to off-white crystalline powder

Usage

Building block in organic synthesis and pharmaceutical industry

Chemical class

Sulfonamide derivative

Subclass

Benzenesulfonyl compounds

Known uses

Pharmaceutical intermediates

Structural features

Bromo and sulfonyl groups attached to a benzene ring with a chlorophenyl substituent

Research status

Not widely studied, further research needed for understanding properties and applications

Potential hazards

Unknown due to limited research

Safety precautions

Not well-established, but should be handled with care due to limited information on hazards

Upstream product

• 24535-57-7 1-bromo-4-(4-chlorophenylsulfanyl)-benzene 
• 108-86-1 bromobenzene 
• 98-60-2 4-chlorobenzenesulfonyl chloride 
• 108-90-7 chlorobenzene 
• 98-58-8 4-bromobenzenesulfonyl chloride 
• 37750-33-7 (4-bromophenyl)(4-aminophenyl)thioether 
• 21969-12-0 4-bromophenyl 4′-nitrophenyl sulfide 
• 14752-66-0 sodium p-chlorobenzenesulphinate 
• 106-40-1 4-bromo-aniline 
• 71-43-2 benzene 

Downstream Products

• 52289-49-3 (4-bromo-3-nitro-phenyl)-(4-chloro-3-nitro-phenyl)-sulfone 
• 106-39-8 bromochlorobenzene 
• 106-37-6 1.4-dibromobenzene 
• 23746-41-0 bis-(3-nitro-4-piperidino-phenyl)-sulfone 

Relevant academic research and scientific papers

Visible-light-driven electron donor-acceptor complex induced sulfonylation of diazonium salts with sulfinates

This work reports an efficient sulfonylation reaction enabled by a visible-light-induced radical coupling reaction between phenyl/heterocyclic diazonium salts and sulfinates. Mechanistic experiments disclosed the formation of a versatile electron donor-acceptor (EDA) complex. This transformation is characterized by an easy operational procedure under mild conditions which avoids transition metals, ligands, catalysts, and oxidants.

Oxidation of Aryl Sulfides to Sulfones with Alumina-Supported Ruthenium Catalyst in Dimethyl Carbonate-Water Media

A new procedure for the oxidation of sulfides to sulfones utilizing heterogeneous ruthenium reagent has been developed. A small amount of ruthenium trichloride (RuCl3) supported on alumina and excess sodium metaperiodate (NaIO4) was used to produce the ruthenium oxidizing catalyst in the reaction mixture. Sodium metaperiodate oxidized the pre-catalyst RuCl3 to RuO4 and also maintained a constant supply of RuO4 by oxidizing lower valent ruthenium ions during the course of the reaction. An environmentally friendly solvent mixture of dimethyl carbonate (DMC) and water was employed. A wide variety of aromatic sulfides were oxidized to sulfones in good to excellent yields by utilizing this procedure.

Metal and solvent free selective oxidation of sulfides to sulfone using bifunctional ionic liquid [pmim]IO4

The oxidation of organo-sulfides to sulfones has been accomplished using an easily accessible bifunctional ionic liquid, [pmim]IO4 in the absence of any other oxidants, metal and organic solvent at ambient temperature. A variety of sulfides including dialkyl, aryl-alkyl, diaryl, and aryl-hetero aryl have been oxidized to the corresponding functionalized sulfones in high yields by this procedure.