65108-28-3

Upstream product

• 71606-98-9 C₁₂H₁₆N₂O₂ 
• 1009-62-7 2,2-dimethyl-3-phenylpropionaldehyde 
• 1111-97-3 3-chloro-3-methylbut-1-yne 
• 108-88-3 toluene 
• 221699-65-6 (4,4-dibromo-2,2-dimethyl-but-3-enyl)-benzene 
• 598-25-4 Dimethylallene 
• 100-39-0 benzyl bromide 
• 558-13-4 carbon tetrabromide 

Downstream Products

• 288089-74-7 [1-2H]-3,3-dimethyl-4-phenyl-1-butyne 

Relevant academic research and scientific papers

Copper-catalyzed intramolecular carbotrifluoromethylation of alkynes for the construction of trifluoromethylated heterocycles

A mild and efficient copper-catalyzed intramolecular carbotrifluoromethylation of alkynes has been achieved in the presence of Togni reagent as trifluoromethylating reagent. The reaction tolerates a range of substrates to give a group of trifluoromethylated heterocycles with high selectivities. A plausible mechanism was proposed on the basis of experimental results. And the Togni award goes to Copper-catalyzed intramolecular carbotrifluoromethylation of alkynes is carried out with a Togni reagent as the trifluoromethylating reagent (see scheme). Various trifluoromethylated heterocycles are synthesized in moderate to good yields. Moreover, a range of common functional groups is tolerated under the reaction conditions.

Biarylphosphonite gold(I) complexes as superior catalysts for oxidative cyclization of propynyl arenes into indan-2-ones

Striking gold: A series of variously functionalized propynyl arenes was smoothly converted into indan-2-ones by a new gold(I)-catalyzed oxidative cyclization process. [LAu]NTf2 (Tf=trifluoromethanesulfonyl) is a superior catalyst both in terms of yield and kinetics for the present transformation. Copyright

Synthesis and inhibitory activity of 4-alkynyl and 4-alkenylquinazolines: Identification of new scaffolds for potent EGFR tyrosine kinase inhibitors

The present study identified several 4-alkynyl and 4-alkenylquinazolines that serve as novel and potent EGFR tyrosine kinase inhibitors. The IC50 values of these compounds are in the nanomolar range. In addition, the 4-(4-phenylbut-1-yn/en-yl)q

Stereochemical course of the hydrogen migration in the boron trifluoride etherate-catalyzed rearrangement of 1,1-disubstituted epoxides

Mechanistic studies on the BF3.Et2O-catalyzed rearrangement of optically active, regioselectively deuterated 1,1-disubstituted epoxides to aldehydic products revealed that the two hydrogens migrate at the migration terminus with oppo