65134-44-3Relevant academic research and scientific papers
Copper-catalyzed direct cyanation of terminal alkynes with benzoyl cyanide
Du, Yan,Li, Zheng
, p. 4622 - 4625 (2018/11/27)
Copper-catalyzed direct cyanation of terminal alkynes is achieved using less toxic, stable and easy to handle benzoyl cyanide as a cyanide source and air as an oxidant. This protocol provides a good alternative to the preparation of 3-arylpropiolonitriles
Asymmetric Hydrogenation of β-Aryloxy/Alkoxy Cinnamic Nitriles and Esters
Kong, Duanyang,Li, Meina,Wang, Rui,Zi, Guofu,Hou, Guohua
supporting information, p. 4916 - 4919 (2016/10/18)
A highly efficient and enantioselective hydrogenation of β-aryloxy/alkoxy cinnamic nitriles and esters under mild conditions has been realized by using a rhodium catalyst with a chiral f-spiroPhos ligand. The method provides efficient access to the asymme
Synthesis of (Z)-3-aryloxy-acrylonitriles, (E)-3-aryloxy-acrylonitriles and 3-cyanobenzofurans through the sequential reactions of phenols with propiolonitriles
Zhou, Wei,Zhang, Yicheng,Li, Pinhua,Wang, Lei
experimental part, p. 7184 - 7196 (2012/10/08)
A Na2CO3-promoted addition of phenols to propiolonitriles generated (Z)-3-aryloxy-acrylonitriles in nearly quantitative yields with exclusively Z-isomers, and a DABCO-promoted addition reaction of phenols with propiolonitriles afforded mainly (E)-3-aryloxy-acrylonitriles with high yields. The obtained (E)-3-aryloxy-acrylonitriles underwent intramolecular cyclization to give 3-cyanobenzofurans in good yields through palladium-catalyzed direct C-H bond functionalization.
