65189-64-2 Usage
Uses
Used in Pharmaceutical Industry:
Enkephalinamide-Leu, Ala(2)is used as a potential analgesic agent for the treatment of chronic pain. It is utilized for its ability to modulate pain signals through its action as a delta opioid receptor agonist, offering an alternative to traditional opioid medications with the prospect of reduced side effects.
Used in Pain Research:
In the field of pain research, enkephalinamide-Leu, Ala(2)is used to study the mechanisms of pain modulation and the potential for developing new treatments for chronic pain conditions. Its effects in animal models provide valuable insights into the role of delta opioid receptors in pain management and the development of novel therapeutic approaches.
Used in Drug Development:
Enkephalinamide-Leu, Ala(2)is utilized in drug development as a lead compound for the creation of new medications aimed at treating chronic pain. Its unique mechanism of action and the demonstrated efficacy in animal models make it a promising candidate for further research and development into a potential new class of pain therapeutics.
Check Digit Verification of cas no
The CAS Registry Mumber 65189-64-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,5,1,8 and 9 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 65189-64:
(7*6)+(6*5)+(5*1)+(4*8)+(3*9)+(2*6)+(1*4)=152
152 % 10 = 2
So 65189-64-2 is a valid CAS Registry Number.
InChI:InChI=1/C29H40N6O6/c1-17(2)13-23(26(31)38)35-29(41)24(15-19-7-5-4-6-8-19)34-25(37)16-32-27(39)18(3)33-28(40)22(30)14-20-9-11-21(36)12-10-20/h4-12,17-18,22-24,36H,13-16,30H2,1-3H3,(H2,31,38)(H,32,39)(H,33,40)(H,34,37)(H,35,41)/t18-,22+,23+,24+/m1/s1
65189-64-2Relevant academic research and scientific papers
Effects of amino acid chirality and the chemical linker on the cell permeation characteristics of cyclic prodrugs of opioid peptides
Liederer, Bianca M.,Fuchs, Tarra,Velde, David Vander,Siahaan, Teruna J.,Borchardt, Ronald T.
, p. 1261 - 1270 (2007/10/03)
Previously, our laboratory showed that the oxymethyl-modified coumarinic acid (OMCA) cyclic prodrug of the opioid peptide DADLE ([D-Ala 2,D-Leu5]-Enk, H-Tyr-D-Ala-Gly-Phe-D-Leu-OH) exhibited low permeation across both the intestinal
Use of 1-(2-Naphthylsulfonyloxy)-6-nitrobenzotriazole as a Novel Coupling Reagent in the Solid-phase Synthesis of Bioactive Peptides
Kundu, Bijoy,Agarwal, Kamlesh C.
, p. 200 - 201 (2007/10/03)
1-(2-Naphthylsulfonyloxy)-6-nitrobenzotriazole (N-NSBt) has been employed as an efficient coupling reagent in the solid-phase synthesis of bioactive peptides: the peptides were obtained in good yields using both Boc as well as Fmoc chemistry of peptide sy
SOLID-PHASE SYNTHESIS OF SOME ANALOGS OF LEU-ENKEPHALIN, β-CASOMORPHIN AND DYNORPHIN
Kojro, Elzbieta,Grzonka, Zbigniew
, p. 163 - 171 (2007/10/02)
Syntheses of seventeen opioid peptides from families of Leu-enkephalin, β-casomorphin and dynorphin have been described.
Synthesis and pharmacological study of some enkephalin analogs in relation to the plurality of opiate receptors
Audigier,Mazarguil,Gout,Cros
, p. 173 - 177 (2007/10/02)
We have synthesized a series of enkephalin analogs and measured their affinity for each type of 'opiate' receptor, the μ receptor and the δ receptor. Furthermore, we have determined their respective antinociceptive activity after intracerebroventricular i
