65189-64-2

Basic information

• Product Name: enkephalinamide-Leu, Ala(2)-
• Synonyms: enkephalinamide-Leu, Ala(2)-;(2-D-alanine,5-leucine)enkephalin amide
• CAS NO: 65189-64-2
• Molecular Formula: C₂₉H₄₀N₆O₆
• Molecular Weight: 568.6645
• Mol File: 65189-64-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 1005.6°C at 760 mmHg
• Flash Point: 561.9°C
• Appearance: /
• Density: 1.238g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.581
• CAS DataBase Reference: enkephalinamide-Leu, Ala(2)-(CAS DataBase Reference)
• NIST Chemistry Reference: enkephalinamide-Leu, Ala(2)-(65189-64-2)
• EPA Substance Registry System: enkephalinamide-Leu, Ala(2)-(65189-64-2)

Safety Data

• Hazardous Substances Data: 65189-64-2(Hazardous Substances Data)

Usage

General Description

Enkephalinamide-Leu, Ala(2)- is a synthetic opioid peptide that acts as an agonist at the delta opioid receptor. It is a modified form of the endogenous enkephalin peptide, which is involved in pain modulation and the regulation of emotions. Enkephalinamide-Leu, Ala(2)- has been studied for its potential as an analgesic and has shown promising results in animal models of pain. It may have the potential to be used as an alternative to traditional opioid medications for the treatment of chronic pain, with potentially fewer side effects. However, further research is needed to fully understand its safety and efficacy in humans.

InChI:InChI=1/C29H40N6O6/c1-17(2)13-23(26(31)38)35-29(41)24(15-19-7-5-4-6-8-19)34-25(37)16-32-27(39)18(3)33-28(40)22(30)14-20-9-11-21(36)12-10-20/h4-12,17-18,22-24,36H,13-16,30H2,1-3H3,(H2,31,38)(H,32,39)(H,33,40)(H,34,37)(H,35,41)/t18-,22+,23+,24+/m1/s1

Upstream product

• 74825-83-5 Boc-(L)(α-Me)Tyr-OH 
• 78537-07-2 N-(tert-butyloxycarbonyl)-L-tyrosyl-D-alanylglycine methyl ester 
• 74392-86-2 N-(tert-butyloxycarbonyl)-L-tyrosyl-D-alanine methyl ester 
• 64410-47-5 N-(tert-butyloxycarbonyl)-L-tyrosyl-D-alanylglycine 
• 71591-34-9 N-(tert-butyloxycarbonyl)-L-tyrosyl-D-alanine 
• 74098-65-0 H-(D)Ala-Gly-OBu-t 
• 10466-61-2 (2S)-amino-4-methylpentanamide hydrochloride 
• 38678-59-0 L-Phe-L-Leu-NH₂ 
• 69193-13-1 Cbz-L-Phe-L-Leu-NH₂ 
• 3397-32-8 N-(benzyloxycarbonyl)-phenylalanine-N-hydroxysuccinimide ester 
• 67582-10-9 Boc Tyr D_.Ala Gly Phe OH 
• 85574-42-1 Z-Tyr(Z)-(D)Ala-Gly-Phe-Leu-NH₂ 
• 80166-88-7 2>-5>-enkephalinamide 
• 74392-85-1 Boc Tyr D_.Ala Gly Phe Leu NH₂ 

Relevant articles and documents

Effects of amino acid chirality and the chemical linker on the cell permeation characteristics of cyclic prodrugs of opioid peptides

Previously, our laboratory showed that the oxymethyl-modified coumarinic acid (OMCA) cyclic prodrug of the opioid peptide DADLE ([D-Ala 2,D-Leu5]-Enk, H-Tyr-D-Ala-Gly-Phe-D-Leu-OH) exhibited low permeation across both the intestinal

SOLID-PHASE SYNTHESIS OF SOME ANALOGS OF LEU-ENKEPHALIN, β-CASOMORPHIN AND DYNORPHIN

Syntheses of seventeen opioid peptides from families of Leu-enkephalin, β-casomorphin and dynorphin have been described.

Synthesis and pharmacological study of some enkephalin analogs in relation to the plurality of opiate receptors

We have synthesized a series of enkephalin analogs and measured their affinity for each type of 'opiate' receptor, the μ receptor and the δ receptor. Furthermore, we have determined their respective antinociceptive activity after intracerebroventricular i