67582-10-9Relevant articles and documents
Hydrazone linker as a useful tool for preparing chimeric peptide/ Nonpeptide bifunctional compounds
Dyniewicz, Jolanta,Lipinski, Piotr F. J.,Kosson, Piotr,Lesniak, Anna,Bochynska-Czyz, Marta,Muchowska, Adriana,Tourwe, Dirk,Ballet, Steven,Misicka, Aleksandra,Lipkowski, Andrzej W.
supporting information, p. 73 - 77 (2017/12/12)
The area of multitarget compounds, joining two pharmacophores within one molecule, is a vivid field of research in medicinal chemistry. Not only pharmacophoric elements are essential for the design and activity of such compounds, but the type and length o
Effects of amino acid chirality and the chemical linker on the cell permeation characteristics of cyclic prodrugs of opioid peptides
Liederer, Bianca M.,Fuchs, Tarra,Velde, David Vander,Siahaan, Teruna J.,Borchardt, Ronald T.
, p. 1261 - 1270 (2007/10/03)
Previously, our laboratory showed that the oxymethyl-modified coumarinic acid (OMCA) cyclic prodrug of the opioid peptide DADLE ([D-Ala 2,D-Leu5]-Enk, H-Tyr-D-Ala-Gly-Phe-D-Leu-OH) exhibited low permeation across both the intestinal