65203-01-2

Upstream product

• 131703-59-8 (E)-1,5-Diphenyl-3-trimethylsilanyloxy-pent-4-en-1-one 
• 14371-10-9 (E)-3-phenylpropenal 
• 100-52-7 benzaldehyde 
• 115237-10-0 3-methyl-2-phenacyl-2-phenylbenzothiazoline 
• 104-55-2 3-phenyl-propenal 
• 70-11-1 α-bromoacetophenone 
• 98-86-2 acetophenone 
• 13735-81-4 1-styrenyloxytrimethylsilane 
• 614-57-3 1,5-diphenylpenta-2,4-dien-1-one 

Relevant academic research and scientific papers

Cellulosic CuI Nanoparticles as a Heterogeneous, Recyclable Catalyst for the Borylation of α,β-Unsaturated Acceptors in Aqueous Media

Abstract: We have demonstrated that cellulosic CuI nanoparticles could perform as an efficient heterogeneous catalyst for the synthesis of useful organoboron compounds. Desired β-borylation products were all obtained in good to excellent yields under mild

Method for preparing organoboron compound and beta-hydroxy compound by supported copper ion Y type molecular sieve catalyst

The invention relates to a method for preparing an organoboron compound and a beta-hydroxy compound by a supported copper ion Y type molecular sieve catalyst. The method for preparing the organoboroncompound mainly comprises the following steps: the step

Development of N,N-bis(perfluoroalkanesulfonyl)squaramides as new strong Br?nsted acids and their application to organic reactions

New strong Br?nsted acids derived from a squaric acid scaffold bearing different perfluoroalkanesulfonyl groups have been developed and applied to several organic reactions. These squaramides are bench-stable and exhibit much higher reactivities in several organic reactions than squaric acid itself. N,N-Bis(trifluoromethanesulfonyl)squaramide 2a was applied to the Mukaiyama aldol reaction and Mukaiyama Michael reaction. Mechanistic studies revealed that the Br?nsted acid might be the predominant catalyst through direct protonation of carbonyl compound by the acid itself rather than the silylated Br?nsted acid. The utility of this acid 2a was further extended to Hosomi-Sakurai allylation of aldehydes and a carbonyl-ene reaction. Furthermore, other squaramides 2b and c bearing longer perfluoroalkyl chains have been developed, which are also bench-stable and displayed similar reactivities with squaramide 2a in several organic reactions.

Aldol reactions of α-bromoalkyl phenyl ketones and aldehydes with tin(IV) iodide and tetrabutylammonium iodide

Aldol reactions of α-bromoacetophenone and aldehydes in dichloromethane produced the corresponding E-α,β-unsaturated ketones at 25 °C with one equimolar amount of tin(IV) iodide, one equimolar amount of tetrabutylammonium iodide and one equimolar amount of N,N- diisopropylethylamine, and produced the corresponding β-hydroxy ketones at -80 °C with one equimolar amount of tin(IV) iodide and two equimolar amounts of tetrabutylammonium iodide. Using one equimolar amount of tin(IV) iodide and two equimolar amounts of tetrabutylammonium iodide at -80 °C in dichloromethane, α-bromopropiophenone reacted with aldehydes to afford the corresponding syn-α-methyl-β-hydroxy ketones selectively. Georg Thieme Verlag Stuttgart.

Intermolecular aldol type reactions of phenacyl bromide with aldehydes mediated by active metallic indium in aqueous media

Mediated by active metallic indium generated in situ from metallic samarium and InCl3.4H2O, phenacyl bromide and aldehydes smoothly underwent intermolecular aldol type reaction in aqueous media affording β-hydroxy ketones in good yie

NOVEL ALDOL-TYPE REACTION UTILIZING 3-METHYL-2-PHENYL-2-(2-OXOALKYL)BENZOTHIAZOLINE AS AN ENOLATE TRANSFERRING REAGENT

An enolate transfer-type aldol reaction of the title benzothiazoline with aldehydes was successfully achieved in the presence of SnCl4 to afford the cross aldol products.

REFORMATSY TYPE REACTION BY MEANS OF Bu3SnAlEt2 or Bu3PbAlEt2

Treatment of α-halo carbonyl compounds with title Sn-Al or Pb-Al reagents provides enolates which react with aldehydes or ketones to give β-hydroxy carbonyl compounds effectively.

A New and Highly Effectiwe Aldol Synthesis

A new approach has been demonstrated for the regiospecific aldol synthesis by the simultaneous addition of α-halo carbonyl derivatives and aldehydes or ketones to a suspension of diethylaluminium chloride and zinc in tetrahydrofuran at low temperature.This technique is also employable under mild conditions for the Reformatsky reaction to give β-hydroxy esters in excellent yield.One of the unique synthetic applications of this process is illustrated by the intramolecular cyclization of α-bromo esters of ω-hydroxy aldehyde,which produces macrolides, an important cla ss of compounds in the antibiotic field.