65226-98-4

Upstream product

• 82031-71-8 (1R*,2S*)-2-(phenylethynyl)cyclohexanol 
• 36449-64-6 (-)-trans-2-phenethyl-cyclohexanol 
• 16306-39-1 (-)-cis-1,2,3,4,4a,9,10,10a-octahydro-phenanthrene 
• 17040-65-2 1-cyclohexenyl(phenyl)methanone 
• 24731-17-7 ethyl 2-(2-oxocyclohexyl)acetate 
• 21405-66-3 7A-phenyl-hexahydro-benzofuran-2-one 
• 124620-30-0 1-phenethyl-cyclohexanol 
• 186581-53-3 diazomethane 
• 1203-67-4 cis-1,2,3,4,4a,9a-hexahydro-9H-fluoren-9-one 
• 532-27-4 1-chloroacetophenone 
• 110-83-8 cyclohexene 
• 16306-39-1 1,2,3,4,4a,9,10,10a-octahydrophenanthrene 
• 52092-27-0 (+/-)-(cis-2-phenyl-cyclohexyl)-acetic acid 
• 16306-39-1 cis-1,2,3,4,4a,9,10,10a-octahydrophenanthrene 

Downstream Products

• 85-01-8 phenanthrene 
• 7498-82-0 (+/-)-9-semicarbazono-cis-1.2.3.4.4a.9.10.10a-octahydro-phenanthrene 
• 16804-85-6 (+/-)-cis-1.2.3.4.4a.10a-Hexahydro-phenanthren 

Relevant academic research and scientific papers

Oxidative Kinetic Resolution of cis -Fused Tricyclic 1-Tetralone Derivatives by Guanidine-Bisurea Bifunctional Organocatalyst

We present an enantioselective synthesis of cis -fused tricyclic 1-tetralones via oxidative kinetic resolution in the presence of cumene hydroperoxide (CHP) and guanidine-bisurea bifunctional organocatalyst. This reaction affords the corresponding α-hydroxylation products together with unreacted tetralones in good to high enantioselectivity, with s values as high as 42. The reaction was successfully applied for the synthesis of the core structure of a kainoid derivative, 4-(2-methoxyphenyl)-2-carboxy-3-pyrrolidineacetic acid (MFPA).

Three-Component Radical Condensations Involving Benzoylmethyl Radicals, Alkenes, and Diphenyl Disulfide

Acyl-substituted methyl radicals (RCOCH2.; R = H, Me, Ph), generated by photolysis of RCOCH2HgCl, add to alkenes, enol ethers, or vinyl sulfides to give adduct radicals that are readily trapped by PhSSPh to yield a three-component condensation product.The presence of an alkali metal carbonate is crucial in preventing side reactions resulting in the conversion of the mercurial to RCOCH3 by PhSH formed in the photolysis.

Metal-catalyzed organic photoreactions. Photoreaction of 2-chloroacetophenone derivatives with olefins in the presence of silver trifluoromethanesulfonate

UV-irradiation of 2-chloroacetophenones and olefins in the presence of silver triflate affords naphthalenone derivatives with high regio and stereoselectivity and chemical yields. A possible mechanism is proposed.

METAL-CATALYZED ORGANIC PHOTOREACTIONS. PHOTOREACTION OF OLEFINS WITH 2-CHLOROACETOPHENONE IN THE PRESENCE OF SILVER TRIFLUOROMETHANESULFONATE

Under UV irradiation with 2-chloroacetophenone in the presence of silver trifluoromethanesulfonate in acetonitrile, acyclic olefins gave naphtalenone derivatives, while cyclic olefins gave phenantrone derivatives in moderate yields.