6523-49-5

Usage

Uses

Used in Pharmaceutical Industry:
1-(4'-Aminophenyl)-1,2,4-triazole is used as a key intermediate in the synthesis of pyrimidine compounds. These compounds have been found to inhibit anaplastic lymphoma kinase (ALK), which is a receptor tyrosine kinase that is often mutated or overexpressed in various types of cancers. By targeting ALK, these pyrimidine compounds can potentially be used in the treatment of cancers, making 1-(4'-Aminophenyl)-1,2,4-triazole a valuable component in the development of novel anticancer drugs.

InChI:InChI=1/C8H8N4/c9-7-1-3-8(4-2-7)12-6-10-5-11-12/h1-6H,9H2

Upstream product

• 6219-55-2 1-(4-nitro-phenyl)-1H-[1,2,4]triazole 
• 288-88-0 1,2,4-Triazole 
• 540-37-4 p-aminoiodobenzene 
• 350-46-9 4-Fluoronitrobenzene 

Downstream Products

• 27199-87-7 phenyl 4-(1H-1,2,4-triazol-1-yl)phenylcarbamate 
• 842127-50-8 compound 43 
• 1000802-40-3 2-iodo-4-(1,2,4-triazol-1-ylmethyl)aniline 
• 733750-53-3 1-[5-nitro-6-(4-[1,2,4]triazol-1-yl-phenylamino)-pyrimidin-4-yl]-piperidine-4-carboxylic acid ethyl ester 
• 1128096-48-9 N-(4-(1H-1,2,4-triazol-1-yl)phenyl)-4-phenylpyrimidin-2-amine 
• 1393367-46-8 1-(4-azidophenyl)-1H-1,2,4-triazole 
• 1393367-49-1 1-(4-(1H-1,2,4-triazol-1-yl)phenyl)-4-((chlorophenoxy)methyl)-1H-1,2,3-triazole 
• 1393367-50-4 1-(4-(1H-1,2,4-triazol-1-yl)phenyl)-4-(p-tolyloxymethyl)-1H-1,2,3-triazole 

Relevant academic research and scientific papers

Acylthiourea compound, preparation method thereof and application of acylthiourea compound in resisting influenza A viruses

The invention discloses an acylthiourea compound, a preparation method thereof and application of the acylthiourea compound in resisting influenza A viruses. Substituted aromatic formyl chloride compounds, amine thiocyanate and substituted aromatic hetero

HEPARAN SULFATE BIOSYNTHESIS INHIBITORS FOR THE TREATMENT OF DISEASES

Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions in need of inhibition of heparan sulfate biosynthesis.

IMINOSUGARS USEFUL FOR THE TREATMENT OF VIRAL DISEASES

Formula IA, ad their use for treating viral infections.

Five-And-Six-Membered Heterocyclic Compound, And Preparation Method, Pharmaceutical Composition And Use Thereof

A five-and-six-membered heterocyclic compound as represented by general formula I, pharmaceutically acceptable salt, metabolite, metabolic precursors or drug precursors thereof, preparation method, pharmaceutical composition, and use thereof; the five-and-six-membered heterocyclic compound has activity as a Janus kinase (JAK) inhibitor, and can be used to prepare drugs for treating diseases caused by the abnormal activity of kinase, such as cell proliferation diseases like cancer.

Highly active recyclable heterogeneous Pd/ZnO nanoparticle catalyst: Sustainable developments for the C-O and C-N bond cross-coupling reactions of aryl halides under ligand-free conditions

Efficient Pd supported on ZnO nanoparticles for the ligand-free O-arylation and N-arylation of phenols and various N-H heterocycles with aryl chlorides, bromides, and iodides were readily synthesized and characterized. The amount of palladium on ZnO is 9.84 wt% (0.005 g of the catalyst contains 462 × 10-8 mol% of Pd) which was determined by ICP analysis. This nano sized Pd/ZnO with an average particle size of 20-25 nm and specific surface area 40.61 m2 g-1 was used as a new reusable heterogeneous catalyst for the formation of C-O and C-N bonds in organic synthesis. This protocol gives the arylated product in satisfactory yields without any N2 or Ar flow. The catalyst can be recovered and recycled several times without marked loss of activity.

Synthesis of novel heteroarenes based [1,2,3]-triazoles via click chemistry and their evaluation for antibacterial activity

A series of heteroarenes based [1,2,3]-triazole derivatives 8a-h and 9a-f has been synthesized via click chemistry through Huisgen [2+3] cycloaddition reaction of heteroarylazides 7a-e with alkynes (3a-c, propargyl alcohol or phenyl acetylene) in the presence of CuSO4.5H2O and sodium ascorbate in t-butanol and water (1:1) mixture at 25°C in good to excellent yields (74-94%). All the newly synthesized compounds have been characterized on the basis of analytical and spectral data. The compounds 8a, 8e, 9a, 9b, 9c and 9e have been evaluated for their preliminary in-vitro antibacterial efficacy against a panel of two Gram-positive bacteria viz. Staphylococcus aureus and Streptococcus mutans and two Gramnegative bacteria viz. Escherichia coli and Pseudomonas aeruginosa using the Agar disc diffusion method.

IMIDAZOQUINOLINES AS LIPID KINASE INHIBITORS

The invention relates to novel organic compounds of formula (I) processes for the preparation thereof, the application thereof in a process for the treatment of the human or animal body, the use thereof - alone or in combination with one or more other pharmaceutically active compounds - for the treatment of an inflammatory or obstructive airway disease, such as asthma, disorders commonly occurring in connection with transplantation, or a proliferative disease, such as a tumor disease.

Amide thiadiazole inhibitors of plasminogen activator inhibitor-1

Methods of treating disorders associated with elevated levels of PAI-1 are disclosed comprising administering to a patient in need thereof a therapeutically effective amount of at least one compound of formula at least one compound of formula (I), or a ph

Optically active antifungal azoles. X. Synthesis and antifungal activity of N-[4-(azolyl)phenyl]- and N-[4-(azolylmethyl)phenyl]-N′-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy -1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-azolones

New optically active antifungal azoles, N-[4-(azolyl)phenyl]- and N-[4-(azolylmethyl)phenyl]-N′-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy -1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]azolones (1, 2, 3), were prepared in a stereocontrolled manner. Compounds 1