6523-49-5

Basic information

• Product Name: 1-(4'-AMINOPHENYL)-1,2,4-TRIAZOLE
• Synonyms: BUTTPARK 95\50-84;BENZENAMINE, 4-(1H-1,2,4-TRIAZOL-1-YL)-;ART-CHEM-BB B021934;1-(4'-AMINOPHENYL)-1,2,4-TRIAZOLE;1-(4-AMINOPHENYL)-1,2,4-TRIAZOLE;4-[1,2,4]TRIAZOL-1-YLANILINE;4-[1,2,4]TRIAZOL-1-YL-PHENYLAMINE;4-(1H-1,2,4-TRIAZOL-1-YL)ANILINE
• CAS NO: 6523-49-5
• Molecular Formula: C₈H₈N₄
• Molecular Weight: 160.18
• Product Categories: Amines;Phenyls & Phenyl-Het;Phenyls & Phenyl-Het;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 6523-49-5.mol
• Article Data: 12

Chemical Properties

• Melting Point: 142 °C
• Boiling Point: 375.3 °C at 760 mmHg
• Flash Point: 180.8 °C
• Appearance: /
• Density: 1.32g/cm³
• Vapor Pressure: 7.87E-06mmHg at 25°C
• Refractive Index: 1.689
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 3.52±0.10(Predicted)
• CAS DataBase Reference: 1-(4'-AMINOPHENYL)-1,2,4-TRIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4'-AMINOPHENYL)-1,2,4-TRIAZOLE(6523-49-5)
• EPA Substance Registry System: 1-(4'-AMINOPHENYL)-1,2,4-TRIAZOLE(6523-49-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-24/25
• Hazardous Substances Data: 6523-49-5(Hazardous Substances Data)

Usage

Uses

4-(1,2,4-Triazol-1-yl)aniline is used in the preparation of pyrimidine compounds that inhibit anaplastic lymphoma kinase and are useful in the treatment of cancers.

InChI:InChI=1/C8H8N4/c9-7-1-3-8(4-2-7)12-6-10-5-11-12/h1-6H,9H2

Upstream product

• 288-88-0 1,2,4-Triazole 
• 540-37-4 p-aminoiodobenzene 
• 350-46-9 4-Fluoronitrobenzene 
• 6219-55-2 1-(4-nitro-phenyl)-1H-[1,2,4]triazole 

Downstream Products

• 27199-87-7 phenyl 4-(1H-1,2,4-triazol-1-yl)phenylcarbamate 
• 842127-50-8 compound 43 
• 1388155-32-5 4-(4(1H-1,2,4-triazol-1-yl)phenyl)-1-thia-4-azaspiro[4.5]-decan-3-one 
• 1388155-41-6 3-(4-(1H-1,2,4-triazol-1-yl)phenyl)-2-(4-bromophenyl)thiazolidin-4-one 
• 181869-21-6 1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1,2,4-triazol-1-yl)phenyl]-2(1H,3H)-imidazolone 
• 181870-00-8 1-(2,2-diethoxyethyl)-3-[4-(1H-1,2,4-triazol-1-yl)phenyl]urea 
• 181869-82-9 4-[4-(1H-1,2,4-triazol-1-yl)phenyl]semicarbazide 
• 181870-06-4 1-[4-(1H-1,2,4-triazol-1-yl)phenyl]-2-(1H,3H)-imidazolone 
• 94216-81-6 4'-(1,2,4-triazol-1-yl)acetanilide 

Relevant articles and documents

Acylthiourea compound, preparation method thereof and application of acylthiourea compound in resisting influenza A viruses

The invention discloses an acylthiourea compound, a preparation method thereof and application of the acylthiourea compound in resisting influenza A viruses. Substituted aromatic formyl chloride compounds, amine thiocyanate and substituted aromatic hetero

IMINOSUGARS USEFUL FOR THE TREATMENT OF VIRAL DISEASES

Formula IA, ad their use for treating viral infections.

Highly active recyclable heterogeneous Pd/ZnO nanoparticle catalyst: Sustainable developments for the C-O and C-N bond cross-coupling reactions of aryl halides under ligand-free conditions

Efficient Pd supported on ZnO nanoparticles for the ligand-free O-arylation and N-arylation of phenols and various N-H heterocycles with aryl chlorides, bromides, and iodides were readily synthesized and characterized. The amount of palladium on ZnO is 9.84 wt% (0.005 g of the catalyst contains 462 × 10-8 mol% of Pd) which was determined by ICP analysis. This nano sized Pd/ZnO with an average particle size of 20-25 nm and specific surface area 40.61 m2 g-1 was used as a new reusable heterogeneous catalyst for the formation of C-O and C-N bonds in organic synthesis. This protocol gives the arylated product in satisfactory yields without any N2 or Ar flow. The catalyst can be recovered and recycled several times without marked loss of activity.