6219-55-2

Usage

Uses

Used in Pharmaceutical Synthesis:
1-(4-Nitrophenyl)-1H-1,2,4-Triazole is used as a building block in the pharmaceutical industry for the synthesis of various drugs. Its unique chemical structure allows for the development of new therapeutic agents with potential applications in treating a range of diseases.
Used in Agrochemical Development:
In the agrochemical industry, 1-(4-Nitrophenyl)-1H-1,2,4-Triazole is utilized as a key component in the creation of novel agrochemicals. Its incorporation into these products can lead to the development of more effective and targeted pest control solutions.
Used in Material Science:
1-(4-Nitrophenyl)-1H-1,2,4-Triazole is employed as a component in the field of material science, where it contributes to the development of new materials with specific properties. Its unique structure can enhance the performance of materials in various applications, such as coatings, adhesives, and polymers.
Used as a Research Tool in Biological Studies:
1-(4-Nitrophenyl)-1H-1,2,4-Triazole serves as a valuable research tool in the study of biological processes. Its ability to interact with biological systems allows scientists to gain insights into various cellular mechanisms and pathways, potentially leading to the discovery of new therapeutic targets and strategies.
Used in Antiviral Applications:
1-(4-Nitrophenyl)-1H-1,2,4-Triazole is investigated for its potential antiviral properties, making it a candidate for the development of new antiviral drugs. Its ability to inhibit viral replication and reduce viral load could contribute to the treatment and prevention of viral infections.
Used in Antimicrobial Applications:
1-(4-Nitrophenyl)-1H-1,2,4-Triazole is also explored for its antimicrobial properties, with potential use in the development of new antimicrobial agents. Its ability to target and eliminate harmful microorganisms can contribute to the fight against antibiotic-resistant bacteria and other pathogens.
Used in Anticancer Research:
1-(4-Nitrophenyl)-1H-1,2,4-Triazole is being studied for its potential anticancer properties, with the aim of developing new cancer therapies. Its ability to target and inhibit the growth of cancer cells could lead to the development of more effective treatments for various types of cancer.

InChI:InChI=1/C8H6N4O2/c13-12(14)8-3-1-7(2-4-8)11-6-9-5-10-11/h1-6H

Upstream product

• 288-88-0 1,2,4-Triazole 
• 350-46-9 4-Fluoronitrobenzene 
• 636-99-7 4-nitrophenylhydrazine hydrochloride 
• 77287-34-4 formamide 
• 586-78-7 para-nitrophenyl bromide 
• 13423-60-4 1-phenyl-1H-1,2,4-triazole 
• 591-50-4 iodobenzene 
• 636-98-6 p-nitrobenzene iodide 
• 100-00-5 4-chlorobenzonitrile 
• 24067-17-2 4-nitrophenylboronic acid 
• 41253-21-8 sodium triazole 

Downstream Products

• 100-29-8 1-ethoxy-4-nitrobenzene 
• 154643-40-0 1-p-Nitrophenyl-4-methyl-1,2,4-triazolium iodide 
• 1226897-89-7 5-bromo-1-(4-nitrophenyl)-1H-1,2,4-triazole 
• 13417-57-7 1-(2,4-dinitrophenyl)-1H-1,2,4-triazole 
• 1393367-52-6 1-(4-(1H-1,2,4-triazol-1-yl)phenyl)-4-phenyl-1H-1,2,3-triazole 
• 1393367-51-5 (1-(4-(1H-1,2,4-triazol-1-yl)phenyl)-1H-1,2,3-triazole-4-yl)methanol 
• 1393367-50-4 1-(4-(1H-1,2,4-triazol-1-yl)phenyl)-4-(p-tolyloxymethyl)-1H-1,2,3-triazole 
• 1393367-49-1 1-(4-(1H-1,2,4-triazol-1-yl)phenyl)-4-((chlorophenoxy)methyl)-1H-1,2,3-triazole 
• 1393367-46-8 1-(4-azidophenyl)-1H-1,2,4-triazole 
• 152537-06-9 4-(1,2,4-triazol-1-yl)-phenylhydrazine 
• 181869-21-6 1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1,2,4-triazol-1-yl)phenyl]-2(1H,3H)-imidazolone 
• 181870-00-8 1-(2,2-diethoxyethyl)-3-[4-(1H-1,2,4-triazol-1-yl)phenyl]urea 
• 181869-82-9 4-[4-(1H-1,2,4-triazol-1-yl)phenyl]semicarbazide 
• 181870-06-4 1-[4-(1H-1,2,4-triazol-1-yl)phenyl]-2-(1H,3H)-imidazolone 

Relevant academic research and scientific papers

N-Heterocyclic Carbene Copper(I) Complex Catalyzed Coupling of (Hetero)aryl Chlorides and Nitrogen Heterocycles: Highly Efficient Catalytic System

A highly efficient catalytic system for the N-arylation reactions of (hetero)aryl chlorides and nitrogen heterocycles with a copper(I) complex containing a 1,10-phenanthroline analogue N-heterocyclic carbene (NHC) has been reported. The complex was characterized by 1H NMR and 13C NMR spectroscopy and elemental analysis, and its structure was determined by single-crystal X-ray diffraction. The NHC-copper(I) complex was employed as pre-catalyst for Ullmann type N-arylation reactions of (hetero)aryl chlorides with various azoles. A variety of hindered and functionalized azoles and (hetero)aryl chlorides were transformed in good to excellent yields.

Unique CuI-pyridine based ligands catalytic systems for N-arylation of indoles and other heterocycles

Two pyridine-based ligands (N-((pyridin-2-yl) methyl) pyridin-2-amine) L1 and (N-((pyridin-2-yl) methylene) pyridin-2-amine) L2 are explored in present work which are inexpensive, effective and environmentally benign in their properties. These have been utilized for C-N cross coupling reaction resulting in N-arylation. The N-arylation of indole, imidazole and triazole have been successfully carried out with different aryl and heteroaryl halides using these ligands.

Copper nanoparticles incorporated on a mesoporous carbon nitride, an excellent catalyst in the Huisgen 1,3-dipolar cycloaddition and N-arylation of N-heterocycles

Cu nanoparticles with average particles size around 10?nm were incorporated on the surface of a mesoporous carbon nitride support. The XRD and N2 adsorption isotherms show that it maintains a hexagonal mesoporous structure with a high surface a

Efficient and recyclable copper-based MOF-catalyzed N-arylation of N-containing heterocycles with aryliodides

Copper-based MOF-199 was used as an efficient heterogeneous catalyst to catalyze cross-coupling reactions between N-containing heterocycles and aryliodides with high yields. The catalyst can be easily separated from the reaction mixture, and can be reused at least 5 times without significantly decreasing the activity. The XRD results showed that the crystallinity and structure of MOF-199 can be maintained well during the coupling reaction.

HEPARAN SULFATE BIOSYNTHESIS INHIBITORS FOR THE TREATMENT OF DISEASES

Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions in need of inhibition of heparan sulfate biosynthesis.

IMINOSUGARS USEFUL FOR THE TREATMENT OF VIRAL DISEASES

Formula IA, ad their use for treating viral infections.

Heterogeneous sequential N-arylation of N-heterocycles over copper anchored mesoporous silica catalyst

N-Arylation reaction of N-heterocyclic compounds has been carried out in excellent yield using copper anchored SBA-15 catalyst. Sequential N-arylation reactions employing single catalyst under heterogeneous condition provides a straightforward access to a

Cu(0)@Al2O3/SiO2 NPs: An efficient reusable catalyst for the cross coupling reactions of aryl chlorides with amines and anilines

The C-N cross coupling reaction of aryl chlorides with various alkyl/aryl amines catalyzed by copper nanoparticles impregnated on alumina/silica support (Cu(0)@Al2O3/SiO2) was investigated. The prepared catalyst was characterized for its intrinsic physico-chemical and textural properties using XRD, XPS, HR-TEM, BET surface area, SEM-EDAX, H2-TPR and ICP-AES techniques. The catalyst exhibits excellent reactivity and efficacy in the cross-coupling of a wide range of alkyl/aryl amines including challenging anilines with aryl chlorides. The catalyst offers significant advantages such as brevity, milder reaction conditions, excellent yields and high functional group tolerance for C-N cross coupling when compared with the other reported methods. Moreover, this atom-economical methodology does not require an additional ligand or co-catalyst/activator. The Cu(0)@Al2O3/SiO2 catalyst was efficiently applied to a gram scale synthesis of 7-chloro-4-(4-(2-nitrophenyl)piperazin-1-yl)quinolone (2k). The robustness of the catalyst was examined by reusing it for five consecutive runs.

Tamarix gallica leaf extract mediated novel route for green synthesis of CuO nanoparticles and their application for N-arylation of nitrogen-containing heterocycles under ligand-free conditions

We report the green synthesis of CuO nanoparticles (CuO NPs) using Tamarix gallica leaf extract and their catalytic activity for N-arylation of nitrogen-containing heterocycles with aryl halides under ligand-free conditions. Tamarix gallica leaves are used as a bio-material for the first time as reducing agent. The green synthesized CuO NPs was characterized using the powder XRD, TEM, UV-vis and FT-IR. This method offers several advantages, viz. high yields, simple methodology, recyclability of the catalyst and a simple workup procedure.

Catalytic activity and antibacterial properties of nanopolymer-supported copper complex for C-N coupling reactions of amines and nitrogen-containing heterocycles with aryl halides

This paper reports on the antibacterial properties and application of nanopolymer-supported copper complex for the ligand-free C-N coupling reactions of amines and nitrogen-containing heterocycles with aryl halides. This method has the advantages of high yields, simple methodology, and easy workup. The catalyst can be recovered by simple filtration from the reaction mixture and reused several times without significant loss of catalytic activity.