6526-67-6

Basic information

• Product Name: 2-chloro-N,N-dimethyl-benzamide
• Synonyms: 2-chloro-N,N-dimethyl-benzamide;N,N-Dimethyl-2-chlorobenzamide;N,N-Dimethyl-o-chlorobenzamide
• CAS NO: 6526-67-6
• Molecular Formula: C₉H₁₀ClNO
• Molecular Weight: 183.6348
• Mol File: 6526-67-6.mol
• Article Data: 25

Chemical Properties

• Boiling Point: 302.9°Cat760mmHg
• Flash Point: 137°C
• Appearance: Yellow/Liquid
• Density: 1.172g/cm³
• Vapor Pressure: 0.000963mmHg at 25°C
• Refractive Index: 1.544
• CAS DataBase Reference: 2-chloro-N,N-dimethyl-benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-N,N-dimethyl-benzamide(6526-67-6)
• EPA Substance Registry System: 2-chloro-N,N-dimethyl-benzamide(6526-67-6)

Safety Data

• Hazardous Substances Data: 6526-67-6(Hazardous Substances Data)

Usage

Uses

2-Chloro-N,N-dimethylbenzamide is involved in the preparation of repellents.

InChI:InChI=1/C9H10ClNO/c1-11(2)9(12)7-5-3-4-6-8(7)10/h3-6H,1-2H3

Upstream product

• 609-65-4 o-chlorobenzoyl chloride 
• 124-40-3 dimethyl amine 
• 3984-14-3 N,N-dimethylsulfamide 
• 118-91-2 ortho-chlorobenzoic acid 
• 680-31-9 N,N,N,N,N,N-hexamethylphosphoric triamide 
• 68-12-2 N,N-dimethyl-formamide 
• 89-98-5 2-chloro-benzaldehyde 
• 17849-38-6 2-Chlorobenzyl alcohol 
• 2856-63-5 2-Chlorophenylacetonitrile 
• 95-49-8 2-methylchlorobenzene 
• 506-59-2 N,N-dimethylammonium chloride 
• 611-74-5 N,N-dimethylbenzamide 
• 66985-47-5 2-chloro-α-[(trimethylsilyl)oxy]benzeneacetonitrile 
• 104417-75-6 1,1-Bis-(2-chloro-benzoyl)-3,3-dimethyl-urea 

Downstream Products

• 89-98-5 2-chloro-benzaldehyde 
• 610-96-8 methyl chlorobenzoate 
• 112044-02-7 pentacarbonyl{(2-chlorophenyl)(N,N-dimethylamino)carbene}chromium⁽⁰⁾ 
• 6269-46-1 2-(2-chlorophenyl)-1,3-benzothiazole 
• 66635-87-8 5-o-chlorobenzoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid 
• 15482-61-8 2-chloro-N,N-dimethylbenzothioamide 

Relevant articles and documents

Visible-Light Photoredox-Catalyzed Amidation of Benzylic Alcohols

A new photocatalyzed route to amides from alcohols and amines mediated by visible light is presented. The reaction is carried out in ethyl acetate as a solvent. Ethyl acetate can be defined a green and bio-based solvent. The starting materials such as the energy source are easily available, stable, and inexpensive. The reaction has shown to be general and high yielding.

Direct Synthesis of Amides from Oxidative Coupling of Benzyl Alcohols and N-substituted Formamides Using a Co–Al Based Heterogeneous Catalyst

Present work reports the direct synthesis of amides from oxidative coupling of benzyl alcohols with various N-substituted formamides using a cobalt-hydrotalcite (Co-HT) derived catalyst. The Co-HT derived catalysts (Co-HT-2, Co-HT-3 and Co-HT-4 having Co2+/Al3+ molar ratio in the catalyst preparation mixture as 1/1, 2/1 and 3/1 respectively) were prepare following a co-precipitation method and characterized well by powder XRD, XPS, FEG-SEM, EDS, DTG–TGA, FT-IR and N2 physisorption measurements. A range of functional amides were obtained in good yields from oxidative coupling of various substituted benzyl alcohols and a range of N-substituted formamides using Co-HT-3 catalyst and oxidant TBHP. Mechanistic investigation suggests that the amidation reaction is associated with the formation and coupling of radical species. Furthermore, the Co-HT derived catalyst was easily recoverable and recyclable with retained high catalytic activity towards the oxidative coupling of benzyl alcohol with DMF. Graphical Abstract: [Figure not available: see fulltext.].

Synthesis method of amide aryl compound

The invention relates to a synthesis method of an amide aryl compounds. According to the method, Ru-(p-cymene) C12 is taken as a catalyst, K2S2O8 is taken as an oxidizing agent, Xantphos is taken as a ligand, one reactant (N, N-dialkyl formamide) is taken