65266-52-6

Upstream product

• 2050-44-4 N-(2,5-dimethylphenyl)acetamide 
• 75-36-5 acetyl chloride 

Downstream Products

• 80539-09-9 4-amino-2,5-dimethylacetophenone 
• 107816-43-3 2,5,5-trimethyl-2-(4-acetamido-2,5-dimethyl)-1,3-dioxan 
• 1009031-41-7 N-[2,5-dimethyl-4-(2-morpholin-4-yl-2-thioxoethyl)phenyl]acetamide 
• 21339-72-0 4-(acetylamino)-2,5-dimethylbenzoic acid 
• 80539-17-9 4-amino-2,5-dimethylacetophenone 2,6-dimethylphenylhydrazone 
• 107816-49-9 N-(4-methoxyphenyl)-2,5-dimethyl-4-<2-(2,5,5-trimethyl-1,3-dioxanyl)>acetanilide 

Relevant academic research and scientific papers

Quinoline Acids

This invention relates generally to quinoline-based modulators of Liver X receptors (LXRs) and related methods.

Carboxylic acid based quinolines as liver X receptor modulators that have LXRβ receptor binding selectivity

A series of potent and binding selective LXRβ agonists was developed using the previously reported non-selective LXR ligand WAY-254011 as a structural template. With the aid of molecular modeling, it was found that 2,3-diMe-Ph, 2,5-diMe-Ph, and naphthalene substituted quinoline acetic acids (such as quinoline 33, 37, and 38) showed selectivity for LXRβ over LXRα in binding assays.

NEW REARRANGEMENTS OF ARYLHYDRAZONES IN POLYPHOSPHORIC ACID: FORMATION OF DIARYL THIOETHERS AND DIARYLAMINES

When heated at 100 deg C with polyphosphoric acid, several dimethylphenylhydrazones of 4-mercaptoacetophenone, 9, and 4-aminodimethylacetophenones, 12, give 4-acetyl-4'-aminodiphenyl thioethers, 11, and 4-acetyl-4'-aminodiphenylamine derivatives, 16, together with products arising from other, known, paths.Mechanisms of formation of the products are discussed.