65374-14-3

Basic information

• Product Name: 1-Propanone, 1-(2-aminophenyl)-2,2-dimethyl-
• CAS NO: 65374-14-3
• Molecular Formula: C11H15NO
• Molecular Weight: 177.246
• Mol File: 65374-14-3.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: 1-Propanone, 1-(2-aminophenyl)-2,2-dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanone, 1-(2-aminophenyl)-2,2-dimethyl-(65374-14-3)
• EPA Substance Registry System: 1-Propanone, 1-(2-aminophenyl)-2,2-dimethyl-(65374-14-3)

Safety Data

• Hazardous Substances Data: 65374-14-3(Hazardous Substances Data)

Usage

Class

Aromatic ketone

Structure

A dimethyl-substituted phenyl group and an amino group attached to the ketone carbon

Uses

Organic synthesis and pharmaceutical research as a building block for the synthesis of various heterocyclic compounds and pharmaceutical intermediates, and as a reagent in the preparation of various pharmaceutical and medicinal products.

Upstream product

• 677-22-5 tert-butylmagnesium chloride 
• 28144-70-9 anthranilic acid amide 
• 19013-51-5 3-tert-butyl-1H-indole 
• 53904-05-5 3-tert-Butyl-3-hydroxy-2,3-dihydroindol-2-one 
• 4397-55-1 phthalic monoacid monomethyl ester chloride 
• 529-23-7 o-aminobenzaldehyde 
• 100702-93-0 α-(o-aminophenyl)neopentyl alcohol 
• 552-89-6 2-nitro-benzaldehyde 
• 1147856-80-1 1-(2-amino-4-methylphenyl)-2,2-dimethyl-1-propanone 
• 1147856-75-4 RuH(CO)(1-(2-aminophenyl)-2,2-dimethyl-1-propanone(-1H))(PPh₃)₂ 
• 938-16-9 2,2-dimethylpropiophenone 
• 533-58-4 2-Iodophenol 
• 3282-30-2 pivaloyl chloride 
• 1885-29-6 anthranilic acid nitrile 

Downstream Products

• 1229609-94-2 4-(tert-butyl)-2-phenylquinazoline 
• 1147856-75-4 RuH(CO)(1-(2-aminophenyl)-2,2-dimethyl-1-propanone(-1H))(PPh₃)₂ 
• 1147856-76-5 Ru(CO)(1-(2-aminophenyl)-2,2-dimethyl-1-propanone(-1H))(PPh₃)(t-BuC(O)C₆H₄) 
• 7664-41-7 ammonia 
• 1147856-81-2 RuH(CO)(1-(2-amino-5-methylphenyl)-2,2-dimethyl-1-propanone(-1H))(PPh₃)₂ 
• 1147856-77-6 Ru(CO)(1-(2-amino-5-methylphenyl)-2,2-dimethyl-1-propanone(-1H))(PPh₃)(t-BuC(O)C₆H₄) 
• 1417711-24-0 Ru(CO)(1-(6-amino-3-methoxyphenyl)-2,2-dimethyl-1-propanone(-1H))(PPh₃)(t-BuC(O)C₆H₄) 
• 1417711-26-2 Ru(CO)(1-(6-amino-3-fluorophenyl)-2,2-dimethyl-1-propanone(-1H))(PPh₃)(t-BuC(O)C₆H₄) 
• 1417711-25-1 Ru(CO)(1-{2-amino-5-(trifluoromethyl)phenyl}-2,2-dimethyl-1-propanone(-1H))(PPh₃)(t-BuC(O)C₆H₄) 
• 1448622-35-2 C₁₃H₁₃⁽²⁾H₆NO 
• 852290-71-2 2'-deuterio-2,2-dimethylpropiophenone 
• 1331753-44-6 1-(2-((2-chlorophenyl)amino)phenyl)-2,2-dimethylpropan-1-one 
• 1331753-49-1 1-(2-((2-chloro-5-(trifluoromethoxy)phenyl)amino)phenyl)-2,2-dimethylpropanone 
• 1315578-09-6 4-tert-butyl-2-p-tolylquinazoline 

Relevant articles and documents

Ketone-Assisted Ruthenium(II)-Catalyzed C-H Imidation: Access to Primary Aminoketones by Weak Coordination

The ruthenium(II)-catalyzed intermolecular C-H imidation with weakly coordinating ketones provided step-economical access to synthetically useful primary aminophenones. The azide-free C-H imidation strategy occurred with ample scope and excellent function

The Reaction of o-Aminoacetophenone N-Tosylhydrazone and CO2 toward 1,4-Dihydro-2H-3,1-benzoxazin-2-ones

A transition-metal-free reaction of o-aminoacetophenone N-tosylhydrazone and CO2 has been developed, leading to a series of 1,4-dihydro-2H-3,1-benzoxazin-2-ones in moderate to good yields. This procedure proceeds with the sequential fixation of CO2 by amino leading to carbamic acid and the intra- molecular insertion of hydroxyl to carbene. (Figure presented.).

2-Arylindoles: A new entry to transition metal-free synthesis of 2-aminobenzophenones

Various 2-aminobenzophenones were synthesized from readily available 2-arylindoles in DMSO under O2 balloon atmosphere. The synthesis was carried out without the aid of a transition metal catalyst or moisture-sensitive organometallic reagents from 2-arylindoles.