65374-14-3

Usage

Class

Aromatic ketone

Structure

A dimethyl-substituted phenyl group and an amino group attached to the ketone carbon

Uses

Organic synthesis and pharmaceutical research as a building block for the synthesis of various heterocyclic compounds and pharmaceutical intermediates, and as a reagent in the preparation of various pharmaceutical and medicinal products.

Upstream product

• 677-22-5 tert-butylmagnesium chloride 
• 28144-70-9 anthranilic acid amide 
• 19013-51-5 3-tert-butyl-1H-indole 
• 53904-05-5 3-tert-Butyl-3-hydroxy-2,3-dihydroindol-2-one 
• 91640-50-5 2-(2,2-Dimethyl-propionyl)-benzamid, 2-Pivaloyl-benzamid 
• 1885-29-6 anthranilic acid nitrile 
• 594-19-4 tert.-butyl lithium 
• 33148-54-8 2-pivaloylbenzoic acid 
• 4397-55-1 phthalic monoacid monomethyl ester chloride 
• 80167-06-2 2,2-dimethyl-2'-nitropropiophenone 
• 2259-30-5 tert-butylmagnesium bromide 
• 1805-65-8 2-tert-butylindole 
• 533-58-4 2-Iodophenol 
• 3282-30-2 pivaloyl chloride 

Downstream Products

• 1147856-75-4 RuH(CO)(P(C₆H₅)3)2(NHC₆H₄COC(CH₃)3) 
• 1237588-94-1 C₁₂H₁₇N 
• 1229609-94-2 4-(tert-butyl)-2-phenylquinazoline 
• 1315578-10-9 4-tert-butyl-2-(4-chlorophenyl)quinazoline 
• 1315578-09-6 4-tert-butyl-2-p-tolylquinazoline 
• 1331753-49-1 1-(2-((2-chloro-5-(trifluoromethoxy)phenyl)amino)phenyl)-2,2-dimethylpropanone 
• 1331753-44-6 1-(2-((2-chlorophenyl)amino)phenyl)-2,2-dimethylpropan-1-one 
• 1147856-76-5 Ru(CO)(1-(2-aminophenyl)-2,2-dimethyl-1-propanone(-1H))(PPh₃)(t-BuC(O)C₆H₄) 
• 7664-41-7 ammonia 
• 1147856-75-4 RuH(CO)(1-(2-aminophenyl)-2,2-dimethyl-1-propanone(-1H))(PPh₃)₂ 
• 1147856-81-2 RuH(CO)(1-(2-amino-5-methylphenyl)-2,2-dimethyl-1-propanone(-1H))(PPh₃)₂ 
• 1147856-77-6 Ru(CO)(1-(2-amino-5-methylphenyl)-2,2-dimethyl-1-propanone(-1H))(PPh₃)(t-BuC(O)C₆H₄) 
• 1417711-24-0 Ru(CO)(1-(6-amino-3-methoxyphenyl)-2,2-dimethyl-1-propanone(-1H))(PPh₃)(t-BuC(O)C₆H₄) 
• 1417711-26-2 Ru(CO)(1-(6-amino-3-fluorophenyl)-2,2-dimethyl-1-propanone(-1H))(PPh₃)(t-BuC(O)C₆H₄) 

Relevant academic research and scientific papers

Ketone-Assisted Ruthenium(II)-Catalyzed C-H Imidation: Access to Primary Aminoketones by Weak Coordination

The ruthenium(II)-catalyzed intermolecular C-H imidation with weakly coordinating ketones provided step-economical access to synthetically useful primary aminophenones. The azide-free C-H imidation strategy occurred with ample scope and excellent function

Synthesis of Stannylated Aryl Imines and Amines via Aryne Insertion Reactions into Sn?N Bonds

The reaction of in situ generated arynes with stannylated imines to provide ortho-stannyl-aniline derivatives is reported. The readily prepared trimethylstannyl benzophenone imine is introduced as an efficient reagent to realize the aryne σ-insertion reaction. The imine functionality is an established N-protecting group and insertions proceed with good yields and good to excellent regioselectivities. The product anilines are valuable starting materials for follow-up chemistry thanks to the rich chemistry offered by the trimethylstannyl moiety.

The Reaction of o-Aminoacetophenone N-Tosylhydrazone and CO2 toward 1,4-Dihydro-2H-3,1-benzoxazin-2-ones

A transition-metal-free reaction of o-aminoacetophenone N-tosylhydrazone and CO2 has been developed, leading to a series of 1,4-dihydro-2H-3,1-benzoxazin-2-ones in moderate to good yields. This procedure proceeds with the sequential fixation of CO2 by amino leading to carbamic acid and the intra- molecular insertion of hydroxyl to carbene. (Figure presented.).

2-Arylindoles: A new entry to transition metal-free synthesis of 2-aminobenzophenones

Various 2-aminobenzophenones were synthesized from readily available 2-arylindoles in DMSO under O2 balloon atmosphere. The synthesis was carried out without the aid of a transition metal catalyst or moisture-sensitive organometallic reagents from 2-arylindoles.

A Fluorination/Aryl Migration/Cyclization Cascade for the Metal-Free Synthesis of Fluoro-Benzoxazepines

Fluorinated organic molecules are of high interest for many applications across chemical and medical disciplines. Efficient methods for the synthesis of such compounds are thus needed. Within this work, application of the bench-stable cyclic hypervalent i

Substituent effects on stoichiometric and catalytic cleavage of carbon-nitrogen bonds in aniline derivatives by ruthenium-phosphine complexes

The reactivity of various o-acylaniline derivatives with ruthenium complexes was examined. The reaction of o-acylanilines with RuH 2(CO)(PPh3)3 (1) or an activated ruthenium species formulated as "Ru(CO)(PPh3)s

Inhibitors of viral replication, their process of preparation and their therapeutical uses

The present invention relates to compounds, their use in the treatment or the prevention of viral disorders, including HIV.

INHIBITORS OF VIRAL REPLICATION, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES

The present invention relates to compounds, their use in the treatment or the prevention of viral disorders, including HIV.

Metal-free intramolecular oxidative decarboxylative amination of primary α-amino acids with product selectivity

A novel metal-free intramolecular oxidative decarboxylative coupling of primary α-amino acids with 2-aminobenzoketones under mild and neutral conditions was developed. Different quinazolines can be selectively obtained by various oxidants.

A simple and efficient approach to the synthesis of 2-phenylquinazolines via sp3 C-H functionalization

(Figure presented) A facile and novel approach to the synthesis of 2-phenylquinazolines was developed via a tandem reaction following sp 3 C-H functionalization. Twenty-five examples of 2-phenylquinazolines were obtained from easily available 2-aminobenzophenones and benzylic amines with good to excellent yields.