65429-74-5

Upstream product

• 25855-99-6 1-(4-methylphenyl)-3-phenyl-1,3-propanedione 
• 19310-59-9 2-cyano-3-(p-tolyl)acrylamide 
• 98-86-2 acetophenone 
• 4224-87-7 4-methyl-chalcone 
• 18300-87-3 ethyl 2-cyano-3-p-tolylacrylate 
• 52287-59-9 (E)-2-cyano-3-(4-methylphenyl)acrylamide 
• 104-87-0 4-methyl-benzaldehyde 
• 77609-07-5 2-(1-(4-methylphenyl)-3-oxo-3-phenylpropyl)malononitrile 
• 107-91-5 cyanoacetic acid amide 
• 76983-09-0 2-Oxo-6-phenyl-4-p-tolyl-1,2,3,4-tetrahydro-pyridine-3-carbonitrile 

Downstream Products

• 548487-51-0 6-phenyl-4-p-tolyl-pyridin-2-ol 
• 156638-76-5 4-(4-methyl-phenyl)-6-phenyl-2-(triphenylphosphoranylideneamino)-pyridine-3-carbonitrile 
• 156638-73-2 2-azido-4-(4-methyl-phenyl)-6-phenyl-pyridine-3-carbonitrile 
• 74873-35-1 2-amino-4-(4-methyl-phenyl)-6-phenyl-pyridine-3-carbonitrile 
• 143882-76-2 2-chloro-4-(4-methylphenyl)-6-phenyl-pyridine-3-carbonitrile 

Relevant academic research and scientific papers

One-Pot Sequential Synthesis of Fused Isoquinolines via Intramolecular Cyclization/Annulation and their Photophysical Investigation

One of the cyano group of γ-keto malononitrile gets hydrolyzed selectively to an amide in the presence of copper(II) acetate monohydrate. The in situ generated amide undergo an intramolecular dehydrative cyclization to a 1,2-dihydropyridone intermediate.

Cascade synthesis of 2-pyridones using acrylamides and ketones

Microwave assisted non-catalytic condensation of 2-cyanoacetamide with aromatic aldehydes, and enolate mediated Michael-type addition to acrylamide followed by oxidative cyclization, produce 2-pyridones in good to excellent yield. Unsymmetrical ketones produce two regioisomeric enolates, therefore thermodynamic and kinetic products of butan-2-one and pentan-2-one have been isolated and fully characterized. This journal is

A microwave approach to the synthesis of certain 4-(substituted phenyl)-6-phenyl-3-cyano-2-pyridones

A study of the synthesis of 4-(substituted phenyl)-6-phenyl-3-cyano- 2-pyridones from ethyl 2-cyano-3-(substituted phenyl) acrylates and acetophenone is presented. The 2-pyridones were obtained using conventional as well as microwave synthesis under solvent and solvent-free conditions in domestic and laboratory microwave ovens. The structure of the obtained pyridones was confirmed by m.p., FT-IR, NMR and UV data.

A simple and convenient synthesis of 4,6-disubstituted 3-cyanopyridin-2(1H)-ones under solvent-free microwave conditions

A rapid and efficient method for the preparation of 4,6-disubstituted 3-cyanopyridin-2(1H)-ones by the reaction between 1,3-diarylpropen-1-ones and cyanoacetamide using powdered potassium hydroxide under microwave irradiation is reported. Excellent yields and higher purity are obtained in this solvent free one pot synthesis as compared to conventional methods.

Synthesis of aminopyridines from azidopyridines and tetrazolo[1,5-a]pyridines

3-Cyano-1,2-dihydro-pyridine-2-ones 2 have been synthesized via the base-catalyzed cycloaddition of arylidenecyanoacetamide 1 with acetophenone. Chlorination of 2 with POCl3/PCl5 mixture gave the corresponding chloropyridines 3. Reac

Reactions of α,β-Unsaturated Ketones with Cyanoacetamide

3-Aryl-1-phenyl-2-propen-1-ones Ia-f and aroylphenylacetylenes Va-d reacted under reflux for 3 hours with cyanoacetamide in the presence of sodium ethoxide to give the corresponding 4-aryl-3-cyano-6-phenyl-2-(1H)pyridones VI.However, when ketones Ia-e wer