65429-76-7

Upstream product

• 956-04-7 3-(4-chlorophenyl)-1-phenylprop-2-en-1-one 
• 29776-35-0 1-(4-chlorophenyl)-3-phenylprop-2-yn-1-one 
• 107-91-5 cyanoacetic acid amide 
• 104-88-1 4-chlorobenzaldehyde 
• 98-86-2 acetophenone 
• 109-77-3 malononitrile 
• 2286-35-3 ethyl 3-(4-chlorophenyl)-2-cyanoacrylate 
• 19310-60-2 (E)-2-cyano-3-(4-chlorophenyl)-2-propenamide 
• 105-56-6 ethyl 2-cyanoacetate 

Downstream Products

• 156638-75-4 4-(4-chloro-phenyl)-6-phenyl-2-(triphenylphosphoranylideneamino)-pyridine-3-carbonitrile 
• 156638-72-1 2-azido-4-(4-chloro-phenyl)-6-phenyl-pyridine-3-carbonitrile 
• 105387-95-9 2-amino-4-(4-chloro-phenyl)-6-phenyl-pyridine-3-carbonitrile 

Relevant academic research and scientific papers

An efficient and facile synthesis of 2-amino-4,6-diarylbenzene-1,3- dicarbonitrile and 1,2-dihydro-2-oxo-4,6-diarylpyridine-3-carbonitrile under solvent-free conditions

A one-pot three-component condensation of aromatic aldehyde, aromatic ketone, and malononitrile leading to an efficient synthesis of 2-amino-4,6-diarylbenzene-1,3-dicarbonitrile and 1,2-dihydro-2-oxo-4,6- diarylpyridine-3-carbonitrile has been carried out

Cascade synthesis of 2-pyridones using acrylamides and ketones

Microwave assisted non-catalytic condensation of 2-cyanoacetamide with aromatic aldehydes, and enolate mediated Michael-type addition to acrylamide followed by oxidative cyclization, produce 2-pyridones in good to excellent yield. Unsymmetrical ketones produce two regioisomeric enolates, therefore thermodynamic and kinetic products of butan-2-one and pentan-2-one have been isolated and fully characterized. This journal is

An efficient and facile multicomponent synthesis of 4,6-diarylpyridine derivatives under solvent-free conditions

We present an efficient and facile synthesis of 4,6-diaryl-2-oxo-1,2- dihydropyridine-3-carbonitriles (5a-j) via a four-component system of aromatic aldehydes (1), acetophenones (2), ethyl cyanoacetate (3), and ammonium acetate (4). The short reaction tim

A microwave approach to the synthesis of certain 4-(substituted phenyl)-6-phenyl-3-cyano-2-pyridones

A study of the synthesis of 4-(substituted phenyl)-6-phenyl-3-cyano- 2-pyridones from ethyl 2-cyano-3-(substituted phenyl) acrylates and acetophenone is presented. The 2-pyridones were obtained using conventional as well as microwave synthesis under solvent and solvent-free conditions in domestic and laboratory microwave ovens. The structure of the obtained pyridones was confirmed by m.p., FT-IR, NMR and UV data.

Solvent and structural effects on the UV-Vis absorption spectra of some 4,6-disubstituted-3-cyano-2-pyridones

A series of 4,6-disubstituted-3-cyano-2-pyridones was synthesized and their UV-Vis absorption spectra were recorded in the region 200-600 nm in the set of selected solvents. The effects of solvent dipolarity/polarizability and solvent-solute hydrogen-bonding interactions on the spectral shifts were analyzed by means of the linear solvation energy relationship concept of Kamlet and Taft. The influence of solvents as well as substituents on the 2-pyridone/2-hydroxypyridine tautomeric equilibration was evaluated. The absorption band maximum of the 2-hydroxypyridine form is found to appear at a shorter wavelength than that of the 2-pyridone form in all investigated solvents. The replacement of the methyl and phenyl groups at position 6 of the pyridone ring, by a hydroxy group, significantly changes the solvatochromic behavior of the investigated pyridones.

One-pot synthesis of 4,6-diaryl-2-oxo-1,2-dihydropyridine-3-carbonitriles via three-component cyclocondensation under solvent-free conditions

An efficient and facile synthesis of 4,6-diaryl-2-oxo-1,2-dihydropyridine- 3-carbonitriles via three-component cyclocondensation from aromatic aldehydes, aromatic ketones, and 2-cyanoacetamide under solvent-free conditions is described. The mild reaction

An efficient and facile procedure for the synthesis of 4,6-diaryl-2(1H)- pyridones under solvent-free conditions

(Chemical Equation Presented) An efficient and convenient method for the preparation of 4,6-diaryl-2(1H)-pyridones by the one-pot reaction of aromatic aldehydes, aromatic ketones and malononitrile, in the presence of sodium hydroxide under solvent-free co

A simple and convenient synthesis of 4,6-disubstituted 3-cyanopyridin-2(1H)-ones under solvent-free microwave conditions

A rapid and efficient method for the preparation of 4,6-disubstituted 3-cyanopyridin-2(1H)-ones by the reaction between 1,3-diarylpropen-1-ones and cyanoacetamide using powdered potassium hydroxide under microwave irradiation is reported. Excellent yields and higher purity are obtained in this solvent free one pot synthesis as compared to conventional methods.

Reactions of α,β-Unsaturated Ketones with Cyanoacetamide

3-Aryl-1-phenyl-2-propen-1-ones Ia-f and aroylphenylacetylenes Va-d reacted under reflux for 3 hours with cyanoacetamide in the presence of sodium ethoxide to give the corresponding 4-aryl-3-cyano-6-phenyl-2-(1H)pyridones VI.However, when ketones Ia-e wer