65491-01-2

Basic information

• Product Name: (2R)-2-(BENZYLAMINO)PROPANOIC ACID
• Synonyms: (2R)-2-(BENZYLAMINO)PROPANOIC ACID
• CAS NO: 65491-01-2
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.22
• Mol File: 65491-01-2.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 314.1±25.0 °C(Predicted)
• Appearance: /
• Density: 1.126±0.06 g/cm3(Predicted)
• PKA: 2.31±0.10(Predicted)
• CAS DataBase Reference: (2R)-2-(BENZYLAMINO)PROPANOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-2-(BENZYLAMINO)PROPANOIC ACID(65491-01-2)
• EPA Substance Registry System: (2R)-2-(BENZYLAMINO)PROPANOIC ACID(65491-01-2)

Safety Data

• Hazardous Substances Data: 65491-01-2(Hazardous Substances Data)

Usage

General Description

(2R)-2-(Benzylamino)propanoic acid, also known as (R)-N-benzyl-2-aminopropionic acid, is a compound with a molecular formula C10H13NO2. It is a chiral amino acid derivative and belongs to the class of alpha amino acids. This chemical is commonly used in the pharmaceutical industry as a precursor for the synthesis of various drugs and pharmaceutical compounds. It is also used in research laboratories as a building block for the creation of new molecules and for studying the effects of chiral compounds on biological systems. Additionally, (2R)-2-(Benzylamino)propanoic acid may have potential applications in the development of novel drug delivery systems and as a component in biochemical assays.

Upstream product

• 64892-53-1 N-benzylalanine ethyl ester 
• 1634-04-4 tert-butyl methyl ether 
• 159721-22-9 N-benzyl-alanine methyl ester 
• 100-52-7 benzaldehyde 
• 338-69-2 D-Alanine 
• 157163-04-7 tert-Butyl (4S)-3-<(2R)-2-(N-benzylamino)propionyl>-1-methyl-2-oxoimidazolidine-4-carboxylate 
• 7585-47-9 N-benzylalanine 
• 328-42-7 Oxalacetic acid 
• 100-46-9 benzylamine 
• 127-17-3 2-oxo-propionic acid 
• 85753-12-4 N-benzyl-L-alanine tert-butyl ester 
• 73116-18-4 N-benzylidene alanine 
• 121441-01-8 Methyl N-(trifluoroacetyl)-N-benzylalaninate 
• 56-41-7 L-alanin 

Downstream Products

• 95071-12-8 (R)-N-benzyl-1-methoxy-1-oxopropan-2-aminium chloride 
• 6940-80-3 (S)-N-benzylalaninol 
• 7585-47-9 N-benzyl-(S)-alanine 
• 101692-94-8 (rac)-N-benzyl-N-methylalanine 
• 1012787-10-8 3-benzyl-1,2-dimethyl-5-phenylthio-1,2,3,4-tetrahydropyrimido[4,5-d]pyrimidine 
• 1012787-09-5 3-ethyl-1-methyl-2-phenyl-5-phenylthio-1,2,3,4-tetrahydropyrimido[4,5-d]pyrimidine 
• 1199793-34-4 (6R)-7-benzyl-6-methyl-4,7-diazaspiro[2.5]octane-5,8-dione 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF CYCLOPROPYLDIKETOPIPERAZINES AND OF A KEY INTERMEDIATE OF DS-5272

Object of the present invention is an improved process for the preparation of cyclopropyldiketopiperazines and thereof key intermediates.

Controlling Plasma Stability of Hydroxamic Acids: A MedChem Toolbox

Hydroxamic acids are outstanding zinc chelating groups that can be used to design potent and selective metalloenzyme inhibitors in various therapeutic areas. Some hydroxamic acids display a high plasma clearance resulting in poor in vivo activity, though they may be very potent compounds in vitro. We designed a 57-member library of hydroxamic acids to explore the structure-plasma stability relationships in these series and to identify which enzyme(s) and which pharmacophores are critical for plasma stability. Arylesterases and carboxylesterases were identified as the main metabolic enzymes for hydroxamic acids. Finally, we suggest structural features to be introduced or removed to improve stability. This work thus provides the first medicinal chemistry toolbox (experimental procedures and structural guidance) to assess and control the plasma stability of hydroxamic acids and realize their full potential as in vivo pharmacological probes and therapeutic agents. This study is particularly relevant to preclinical development as it allows obtaining compounds equally stable in human and rodent models.

Structure-Activity Relationships of the Peptide Kappa Opioid Receptor Antagonist Zyklophin

The dynorphin (Dyn) A analogue zyklophin ([N-benzyl-Tyr1-cyclo(d-Asp5,Dap8)]dynorphin A(1-11)NH2) is a kappa opioid receptor (KOR)-selective antagonist in vitro, is active in vivo, and antagonizes KOR in the CNS