36337-28-7

Usage

Uses

Used in Pharmaceutical Industry:
5'-amino-6'-(aminomethyl)-[1,1':3',1''-terphenyl]-4'-carbonitrile is used as a building block for the development of new pharmaceutical compounds due to its unique molecular structure and reactivity. Its potential applications in drug discovery and design can lead to the creation of novel therapeutic agents.
Used in Organic Synthesis:
In the field of organic synthesis, 5'-amino-6'-(aminomethyl)-[1,1':3',1''-terphenyl]-4'-carbonitrile serves as a key intermediate for the synthesis of various organic compounds. Its functional groups allow for further chemical modifications, enabling the production of a wide range of molecules with diverse properties.
Used in Materials Science:
5'-amino-6'-(aminomethyl)-[1,1':3',1''-terphenyl]-4'-carbonitrile is utilized in materials science for the development of new materials with specific properties. Its unique molecular structure can contribute to the creation of advanced materials with applications in various industries, such as electronics, coatings, and polymers.
Overall, 5'-amino-6'-(aminomethyl)-[1,1':3',1''-terphenyl]-4'-carbonitrile is a promising chemical compound with a broad range of potential applications across different industries. Its unique structure and reactivity make it an important candidate for further research and development.

Upstream product

• 65515-39-1 3-cyano-4,6-dimethyl-2-methoxypyridine 
• 109-77-3 malononitrile 
• 123-75-1 pyrrolidine 
• 94-41-7 benzalacetophenone 
• 100-52-7 benzaldehyde 
• 98-86-2 acetophenone 
• 1867-38-5 4-chlorobenzylidenemalonodinitrile 
• 614-47-1 1,3-diphenyl-propen-3-one 
• 2826-25-7 2-(4-methylbenzylidene)malononitrile 
• 2700-22-3 Benzylidenemalononitrile 
• 2826-26-8 2-(4-methoxyphenylmethylene)malononitrile 
• 7338-94-5 1,3-diphenyl-2-propynone 

Downstream Products

• 143644-46-6 4-imino-2-thioxo-1,2,3-trihydro-3,5,7-triphenylquinazoline-8-carbonitrile 
• 143644-44-4 4-imino-2-oxo-1,2,3-trihydro-3,5,7-triphenylquinazoline-8-carbonitrile 

Relevant academic research and scientific papers

The reaction of malononitrile with chalcone: A controversial chemical process

Given the significant discrepancies in the several reported results on the reaction of chalcone (1,3-diphenyl-2-propne-1-one) (1) with malononitrile (2), a careful reinvestigation was carried out. Depending upon the reaction conditions either the open-chain Michael adduct (4), an alkoxypyridine (5), an aminoisophthalonitrile (6) or a cyclohexanol (7) is obtained. However, no 4H-pyran could be isolated from this reaction.

Primary 1,2-diamine catalysis III: An unexpected domino reaction for the synthesis of multisubstituted cyclohexa-1,3-dienamines

The first organocatalyzed multicomponent domino reactions of aryl ketones, aldehydes and malononitrile were carried out successfully to afford multisubstituted cyclohexa-1,3-dienamines in satisfactory yields.

A rapid one-pot synthesis of 2,4,6-triaryl-3-aroyl-4-hydroxy-1,1-cyclohexanedicarbonitriles and 2-aminoisophthalonitriles under microwave activation

Ylidenemalononitriles 1 react with a variety of 1,3-diaryl-2-propen-1-ones 2 at ambient temperature and pressure under microwave activation to yield functionalised cyclohexanedicarbonitriles 3 and 2-aminoisophthalonitriles 4 in good yields.

Synthesis of highly substituted 1,6-naphthyridines: A reinvestigation

A reinvestigation of the recently described method of synthesis of highly substituted 1,6-naphthyridines was carried out. It was found out that the reaction of chalcones with malononitrile catalysed by pyrrolidine afforded the mixture of four products both when thermal as well as microwave heating was used. The claimed[1] 1,6-naphthyridines formation were exceptions.

SYNTHESIS OF 4-AMINO-8-CYANOQUINAZOLINES FROM ENONES AND ENALS

The treatment in a sodium methoxide/methanol solution of α,β-unsaturated enones or aldehydes with propanedinitrile in a 1:2 molar ratio led to 2-aminobenzene-1,3-dicarbonitriles.These compounds afforded 4-amino-8-cyanoquinazolines by reaction with formamide or guanidine.

Reactions of Malononitrile with Acetylenic Esters and Ketones

The addition of malononitrile to acetylenic esters and acetylenic ketones catalysed by sodium alkoxides leads to the formation of 3- and 5-cyano-2-pyridones, 2-cyano- and 2,6-dicyano-aniline derivatives, and other products.