655230-45-8Relevant articles and documents
FUSED QUADRACYCLIC COMPOUNDS, COMPOSITIONS AND USES THEREOF
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Paragraph 0688, (2017/08/01)
Provided herein are substituted fused quadracyclic compounds useful as inhibitors of MK2. The invention further provides pharmaceutical compositions of the compounds of the invention. The invention also provides medical uses of substituted fused quadracyclic compounds.
Design, synthesis, and in vitro pharmacology of new radiolabeled γ-hydroxybutyric acid analogues including photolabile analogues with irreversible binding to the high-affinity γ-hydroxybutyric acid binding sites
Sabbatini, Paola,Wellendorph, Petrine,H?g, Signe,Pedersen, Martin H. F.,Br?uner-Osborne, Hans,Martiny, Lars,Fr?lund, Bente,Clausen, Rasmus P.
supporting information; experimental part, p. 6506 - 6510 (2010/11/18)
γ-Hydroxybutyric acid (GHB) is a psychotropic compound endogenous to the brain. Despite its potential physiological significance, the complete molecular mechanisms of action remain unexplained. To facilitate the isolation and identification of the high-affinity GHB binding site, we herein report the design and synthesis of the first 125I-labeled radioligands in the field, one of which contains a photoaffinity label which enables it to bind irreversibly to the high-affinity GHB binding sites.