65535-49-1Relevant academic research and scientific papers
7,8-Disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones i and II in the low nanomolar/subnanomolar range
Maresca, Alfonso,Scozzafava, Andrea,Supuran, Claudiu T.
scheme or table, p. 7255 - 7258 (2011/01/12)
Two series of disubstituted coumarins incorporating ether and acetyl/propionyl moieties in positions 6,7- and 7,8- of the heterocyclic ring were synthesized investigated for the inhibition of the zinc enzyme carbonic anhydrase (CA, EC 4.2.1.1). All these
First enantioselective synthesis of daphneticin and its regioisomer
Ren, Xinfeng,Chen, Xiaochuan,Peng, Kun,Xie, Xingang,Xia, Yamu,Pan, Xinfu
, p. 1799 - 1804 (2007/10/03)
An enantioselective total synthesis of chiral daphneticin and its regioisomer is reported for the first time.
DEFINITE TOTAL SYNTHESIS OF COUMARINOLIGNANS, DAPHNETICIN AND ITS REGIOISOMER
Tanaka, Hitoshi,Ishihara, Masaya,Ichino, Kazuhiko,Ito, Kazuo
, p. 3115 - 3122 (2007/10/02)
The synthesis of 7-benzyloxy-8-hydroxycoumarin (5) and 8-benzyloxy-7-hydroxycoumarin (11) was described and further, by use of 5 as a starting material, daphneticin (1) was synthesized.On the other hand, its regioisomer (2) was also synthesized from (8), readily prepared via two steps from 5, according to the method described in the synthesis of daphneticin.
