65551-44-2

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 130517-94-1 (E)-N-benzyl-1-(4-methoxyphenyl)methanimine 
• 622-72-0 N-(4-methoxylbenzylidene)benzylamine 
• 151-50-8 potassium cyanide 
• 7465-87-4 N-benzyl-4-methoxybenzamide 
• 123-11-5 4-methoxy-benzaldehyde 
• 100-46-9 benzylamine 
• 557-21-1 zinc(II) cyanide 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 143-33-9 sodium cyanide 

Downstream Products

• 78139-31-8 2-Benzylamino-2-(4-methoxy-phenyl)-acetamide 
• 72867-50-6 N-Benzyl-N-[cyano-(4-methoxy-phenyl)-methyl]-benzamide 
• 219487-66-8 N-Benzyl-N-[cyano-(4-methoxy-phenyl)-methyl]-2-nitro-benzamide 
• 2540-53-6 2-(4-methoxyphenyl)glycine 
• 271583-25-6 benzylamino-(4-methoxy-phenyl)-acetic acid 
• 219487-75-9 2-Amino-N-benzyl-N-[cyano-(4-methoxy-phenyl)-methyl]-benzamide 
• 219487-88-4 C₂₆H₂₃ClN₄O₄ 
• 78139-40-9 3-hydroxy-4-p-methoxyphenyl-1,2,5-thiadiazole 
• 40658-73-9 1-(4-methoxyphenyl)-N₁-(phenylmethyl)-1,2-ethanediamine dihydrochloride 

Relevant academic research and scientific papers

Iridium-Catalyzed Reductive Nucleophilic Addition to Secondary Amides

An iridium-catalyzed reductive nucleophilic addition to secondary amides is reported. After the iridium-catalyzed reduction, the resulting imines can undergo the Strecker reaction, the Mannich reaction, allylation, and [3 + 2]-cycloaddition. The method sh

Mechanochemical Activation of Iron Cyano Complexes: A Prebiotic Impact Scenario for the Synthesis of α-Amino Acid Derivatives

Mechanochemical activation of iron cyano complexes by ball milling results in the formation of HCN, which can be trapped and incorporated into α-aminonitriles. This prebiotic impact scenario can be extended by mechanochemically transforming the resulting α-aminonitriles into α-amino amides using a chemical route related to early Earth conditions.

In(III) and Sc(III) based coordination polymers derived from rigid benzimidazole-5,6-dicarboxylic acid: Synthesis, crystal structure and catalytic property

Two new coordination polymers (CPs), [InCl(H2bidc)2(H2O)]n (1) and [Sc(Hbidc)(OH)(H2O)]n (2) (H3bidc = benzimidazole-5,6-dicarboxylic acid) were synthesized through a solvotherma

Lanthanide coordination polymer constructed from 2,2′-bipyridyl-4,4′-dicarboxylic acid: Structure, catalysis and fluorescence

Two new isostructural lanthanide coordination polymers (Ln-CPs) [Ln2(bpdc)3(DMF)2] (Ln = Tb for 1, Eu for 2) with two kinds of one-dimensional channels along the a axis, were synthesized by 2,2′-bipyridyl-4,4′-dicarboxylic acid (H2bpdc) under solvothermal conditions. With exposed Lewis acid Ln3+ centers, 1 as a heterogeneous catalyst shows good catalytic reactivity and selectivity for the Strecker reaction affording medium to excellent conversion yields. Luminescent studies illustrate that 1 and 2 show intensive green and red luminescence triggered by efficient antenna effect of ligands under UV light, respectively. Moreover, 1 exhibits sensitive fluorescent response to Cu2+ in DMF solution.

Catalyst-free, facile, and an efficient synthesis of α-aminonitriles employing Zn(CN)2 as an ecofriendly cyanating agent

An efficient and eco-friendly method has been developed for the synthesis of α-aminonitriles via one-pot three-component condensation of carbonyl compounds, amines, and Zn(CN)2 under mild conditions. This protocol has the features of use of inexpensive, ecofriendly readily available, effective cyanide source, high yield, and simple work-up procedure.

TITANIUM COMPOUNDS AND PROCESS FOR CYANATION OF IMINES

The present invention relates to titanium catalysts for synthesis reactions produced by bringing a reaction mixture comprising a titanium alkoxide and a ligand in contact with water, wherein the ligand is represented by the general formula (e): wherein R

Catalyst-free Strecker reaction in water: A simple and efficient protocol using acetone cyanohydrin as cyanide source

A simple, convenient, and practical method for the synthesis of α-amino nitriles through a one-pot, three-component Strecker reaction of a carbonyl compound, amine, and acetone cyanohydrin in water has been developed. Reactions proceed very efficiently without any catalyst at room temperature with high chemoselectivity and give, in some cases, the expected α-amino nitrile pure after direct separation from water. The protocol is particularly efficient for both aliphatic and aromatic aldehydes, and cyclic ketones, in combination with primary and secondary amines. An unusual application of the Strecker reaction to 1,2-diamines to obtain 1,2-diamino nitriles, and to cyclic secondary amines is reported. Copyright

Asymmetric addition of trimethylsilylcyanide to N-benzylimines catalyzed by recyclable chiral dimeric V(V) salen complex

Chiral dimeric vanadium (V) salen complex (10 mol%) derived from 5,5-Methylene di-[(S,S)-{N-(3-tert-butyl salicylidine)-N′-(3′,5′-di-tert-butyl salicylidene)]-1,2-cyclohexanediamine] with vanadyl suphate followed by auto oxidation was used as efficient catalyst for enantioselective Strecker reaction of N-benzylimines with TMSCN at -30 °C. Excellent yield (92%) of α-aminonitrile and high chiral induction was achieved (ee up to 94%) in case of 2-methoxy substituted N-benzylimines in 10 h. The catalytic system worked well up to four cycles with retention of enantioselectivity.

Mn(III) salen complexes-catalyzed enantioselective addition of trimethyl silylcyanide to N-benzylimines in the presence of 4-phenyl pyridine-N-oxide as an additive

Chiral monomeric and dimeric Mn(III) salen complexes viz., [(S,S)-N,N′-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediaminato manganese(III) chloride and 5,5-methylene di-[(S,S)-{N-(3-tert-butyl salicylidine)-N′-(3′,5′-di-tert-butyl salicylidene)}-1,

KHSO4-catalyzed three-component synthesis of α-aminonitriles

A simple, convenient and general method has been developed for the synthesis of α-aminonitriles by a one-pot three-component condensation of aldehydes, amines and trimethyl silyl cyanide under solvent-free conditions in the presence of a catalytic amount of KHSO4 in good yields. The new method compares well in terms of yields with alternative methods. In general the reaction times are much shorter and the work up much easier.