6557-85-3Relevant articles and documents
Synthesis method of ethyl 8-bromocaprylate
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Paragraph 0060-0063; 0070-0072; 0078-0080; 0085-0087, (2021/07/10)
The invention provides a synthesis method of ethyl 8-bromocaprylate, which comprises the following steps: S1, carrying out substitution reaction on 1,6-dibromohexane and diethyl malonate to obtain a compound 2-(6-bromohexyl)-diethyl malonate; S2, enabling the 2-(6-bromohexyl)-diethyl malonate to carry out ester hydrolysis and a decarboxylation reaction so as to obtain 8-bromocaprylic acid; and S3, carrying out an esterification reaction on the 8-bromocaprylic acid and absolute ethyl alcohol to obtain ethyl 8-bromocaprylate. According to the synthesis method of ethyl 8-bromocaprylate, disclosed by the embodiment of the invention, firstly, 1,6-dibromohexane initial raw material and diethyl malonate are subjected to substitution reaction to generate 2-(6-bromohexyl) diethyl malonate, and then ester hydrolysis and decarboxylation reaction are carried out to obtain 8-bromocaprylic acid; and finally,esterification reaction is carried out to generate ethyl 8-bromocaprylate. The raw materials are easy to obtain, side reactions in the reaction are few, the process is simple, and the method is suitable for industrial production, and has a very wide application prospect.
Combating metastasis of breast cancer cells with a carboplatin analogue containing an all-trans retinoic acid ligand
Cheng, Junjie,Dai, Yi,Huang, Hai,Liu, Yangzhong,Shen, Ai-Zong,Zhu, Yang
supporting information, p. 5039 - 5043 (2020/05/08)
Pt-ATRA, a carboplatin analogue containing an all-trans retinoic acid (ATRA) derivative ligand, was synthesized via a click reaction. Upon cellular internalization, Pt-ATRA exhibits a dual function, releasing an active Pt(ii) moiety to induce cell apoptosis and ATRA to inhibit tumor metastasis.
The synthesis of new potential photosensitizers. 1. Mono-carboxylic acid derivatives of tetraphenylporphyrin
Zieba, Grzegorz,Rojkiewicz, Marcin,Kozik, Violetta,Jarzembek, Krystyna,Jarczyk, Anna,Sochanik, Aleksander,Kus, Piotr
experimental part, p. 153 - 159 (2012/06/30)
A series of mono-alkylcarboxylic acid derivatives of tetraphenylporphyrin have been prepared. All the porphyrins were completely characterized by use of mass, 1H NMR, UV-visible, and fluorescence spectroscopy. Experimental log P were determined
Process for the monoalkylation of C-H acid methylene groups
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Page/Page column 5, (2008/06/13)
The ratio of the alkali(ne earth) carbonate to the methylene group-containing substrate is above 0.6 : 1 in the monoalkylation of C-H acid methylene groups by reaction of the substrate in a polar aprotic solvent with a dihalogen compound having its halogens separated by a chain of at least3C and with reaction being in presence of the alkali(ne earth) carbonates and a phase transfer catalyst and being accompanied by continuous removal of the water formed. An Independent claim is also included for production of omega-haloalkyl-nitriles or -carboxylic acids by reacting a malonic acid diester or cyanoacetic ester with an alpha,omega-dihaloalkane as above and then saponifying and decarboxylating the product.
Thermal properties of liquid-crystalline diols and corresponding bis-urethanes with mesogenic groups of various structures in side chains
Kaspar,Hamplova,Novotna,Studenovsky,Ilavsky
, p. 17 - 30 (2007/10/03)
The liquid-crystalline dials with mesogenic groups of different structures were synthetized and their temperature behavior and existence of mesophases were determined. These compounds were also reacted with phenylisocyanate to form bis-urethanes at the ra
Intramolecular photoreactions of phthalimide-alkene systems. Macrocyclic synthesis through the remote Paterno-Buchi reaction of phthalimide with indole derivatives
Takechi,Machida,Nishizono,Kanaoka
, p. 188 - 196 (2007/10/02)
Upon irradiation, phthalimide-indole in bichromophoric systems underwent intramolecularly remote Paterno-Buchi reaction to give oxeto[2,3-b]indole derivatives containing macrocycles, in competition with Norrish type II reaction.
Synthese de l'acide (dimercapto-1,3 propyl-2)-15 pentadecanoique, complexant potentiel du 99mTc
Alagui, Abdelhakim,Apparu, Marcel,Comet, Michel,Pasqualini, Roberto,Vidal, Michel
, p. 113 - 117 (2007/10/02)
The synthesis of 15-(1,3-dimercapto 2-propyl) pentadecanoic acid was performed in ten steps.One of these steps is the condensation of (5) with 7-bromoheptanoic acid.It is achieved in liquid ammonia or in a HMPA-THF medium with yields higher than 50 percent.In the second case a-5 bromoacid-ratio of 2.1 (slightly superior to the stoichiometry) is sufficient to obtain these yields, whereas in ammonia, the ratio must be higher than 5 and is therefore clearly unfavourable.The reaction times are also much longer in ammonia.The obtention of 5 from diethyl (6-bromohexyl) malonate 2 implies the reduction of ester functions and the substitution of Br by the ethynyl group.The optimal conditions and the sequence of these two steps have been determined.
Acides gras marques en position ω par un nucleide radioactif emetteur γ
Riche, Francoise,Mathieu, Jean-Paul,Vincens, Maurice,Bardy, Andre,Comet, Michel,Vidal, Michel
, p. 49 - 55 (2007/10/02)
The synthesis of many saturated, acetylenic, olefinic (Z or E) fatty acids labeled with 123I or 131I at the ω-position has been achieved.The radioactive iodine atom is introduced by a I-, *I- exchange reaction; the influence on the yield of several parameters - presence of iodine carrier, fatty acid and water concentrations, solution acidity - has been studied.Experimental conditions which produce labeling yields higher than 95percent have been defined; these results have lead to a very easy labeling method used in several hospitals in the external study of myocardial metabolism of fatty acids.
