65610-86-8Relevant academic research and scientific papers
Palladium-Catalyzed [4 + 3] or [2 + 2 + 3] Annulation via C-H Activation and Subsequent Decarboxylation: Access to Heptagon-Embedded Polycyclic Aromatic Hydrocarbons
Yang, Xiumei,Chen, Xiahong,Xu, Yankun,Zhang, Minghao,Deng, Guobo,Yang, Yuan,Liang, Yun
supporting information, p. 2610 - 2615 (2021/04/12)
The construction of a seven-membered ring in the polycyclic aromatic hydrocarbon skeleton remains a notoriously difficult but attractive challenge. Herein a novel palladium-catalyzed [4 + 3] decarboxylative annulation of 2-iodobiphenyls with 2-(2-halophenyl)acrylic acids is reported, which provides an efficient approach for assembling various tribenzo[7]annulenes via a C-H activation and decarboxylation process. Moreover, tribenzo[7]annulenes can be also synthesized via a [2 + 2 + 3] decarboxylative annulation strategy by employing readily available 1,2-halobenzenes, phenylboronic acids, and 2-(2-halophenyl)acrylic acids.
α-Bromoacrylic Acids as C1 Insertion Units for Palladium-Catalyzed Decarboxylative Synthesis of Diverse Dibenzofulvenes
Zhang, Minghao,Deng, Wenbo,Sun, Mingjie,Zhou, Liwei,Deng, Guobo,Liang, Yun,Yang, Yuan
supporting information, p. 5744 - 5749 (2021/08/18)
Herein α-bromoacrylic acids have been employed as C1 insertion units to achieve the palladium-catalyzed [4 + 1] annulation of 2-iodobiphenyls, which provides an efficient platform for the construction of diverse dibenzofulvenes. This protocol enables the formation of double C(aryl)-C(vinyl) bonds via a C(vinyl)-Br bond cleavage and decarboxylation. It is particularly noteworthy that the method features a broad substrate scope, and various interesting frameworks, such as bridged ring, fused (hetero)aromatic ring, and divinylbenzene, can be successfully incorporated into the products.
Selective C?H or N?H Imidoylative Annulation of 2-(2-Isocyanophenyl)-1H-indoles Leading to Diverse Indole-fused Scaffolds
Teng, Fan,Hu, Weiming,Hu, Huaanzi,Luo, Shuang,Zhu, Qiang
, (2019/02/07)
2-(2-Isocyanophenyl)-1H-indoles, a class of functionalized isocyanides containing both aromatic C?H and indolo N?H functionalities, are first applied in selective imidoylative annulation reactions. Scaffolds of 6-aryl 11H-indolo[3,2-c]quinoline and 6-aryl
Synthetic method for resisting leukemia cancer cell active molecule and midbody
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Paragraph 0061-0063, (2018/10/19)
The invention relates to the field of medicine and organic synthesis, and provides a synthetic method for resisting a leukemia cancer cell active molecule and a midbody. By means of intramolecular multicomponent reaction in (2-isocyanatophenyl)-1-methyl-6
N-Methyl Transfer Induced Copper-Mediated Oxidative Diamination of Alkynes
Ho, Hon Eong,Oniwa, Kazuaki,Yamamoto, Yoshinori,Jin, Tienan
supporting information, p. 2487 - 2490 (2016/06/09)
A novel intramolecular oxidative diamination of bis(2-aminophenyl)acetylene for the synthesis of the structurally intriguing -conjugated polyheterocyclic scaffold, 5,10-dihydroindolo[3,2-b]indole (DHII), has been developed under Cu(hfacac)2/Os
