65613-27-6Relevant academic research and scientific papers
1-Acyl-1H-[1,2,4]triazole-3,5-diamine analogues as novel and potent anticancer cyclin-dependent kinase inhibitors: Synthesis and evaluation of biological activities
Lin, Ronghui,Connolly, Peter J.,Huang, Shenlin,Wetter, Steven K.,Lu, Yanhua,Murray, William V.,Emanuel, Stuart L.,Gruninger, Robert H.,Fuentes-Pesquera, Angel R.,Rugg, Catherine A.,Middleton, Steven A.,Jolliffe, Linda K.
, p. 4208 - 4211 (2007/10/03)
A series of 1-acyl-1H-[1,2,4]triazole-3,5-diamine analogues were synthesized as cyclin-dependent kinase (CDK) inhibitors. These compounds showed potent and selective CDK1 and CDK2 inhibitory activities and inhibited in vitro cellular proliferation in various human tumor cells. Representative compound 3b demonstrated in vivo efficacy in a human melanoma A375 xenograft model in nude mice.
Synthesis and photochromic properties of tetrakis(3,5-dimethyl-2-thienyl)- and tetrakis(2,5-dimethyl-3-thienyl)ethylenes
Belen'kii,Gromova,Kolotaev,Nabatov,Krayushkin
, p. 1208 - 1213 (2007/10/03)
Tetrakis(3,5-dimethyl-2-thienyl)ethylene and tetrakis(2,5-dimethyl-3- thienyl)ethylene were obtained from the corresponding dithienyl ketones by the McMurry reaction. The photochromic properties of the compounds obtained were studied.
Effects of base, electrophile, and substrate on the selective alkylation of heteroaromatic systems
Smith, Thomas E.,Mourad, Michelle S.,Velander, Alan J.
, p. 1211 - 1217 (2007/10/03)
Several heteroaromatic systems, including oxazoles, pyrazoles, and thiophenes, are regioselectively alkylated using lithium diethylamide. Effects of substrate, base, and electrophile on the selectivity of this process are surveyed and interpreted.
Phosphorylamides, their preparation and use
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, (2008/06/13)
A phosphorylamide derivative represented by the general formula (I): STR1 wherein R represents an amino group that may be substituted, or a salt thereof, possesses potent antibacterial activity against Helicobacter bacterium, especially Helicobacter pylori, and is useful for prevention or treatment of digestive diseases caused by Helicobacter bacterium, solely or in combination with an antacid or an acid secretion inhibitor.
Regioselective Synthesis of 2-Functionalized Thiophenes by Condensation of α-Mercapto Compounds with β-Aminoenone Derivatives
Alberola, Angel,Andres, Jose M.,Gonzalez, Alfonso,Pedrosa, Rafael,Pradanos, Pedro
, p. 2537 - 2547 (2007/10/02)
2-Acylthiophenes and ethyl 2-thiophenecarboxylates are prepared regioselectively by reaction of 3-chloroenones and 2-acylenammonium chlorides with α-mercapto derivatives in good to moderate yields.
Dianions of Methylated Thiophene-2-carboxylic Acids: Their Formation and Reactivity
Gould, Norman P.,Lee, Ta-Jyh
, p. 4528 - 4530 (2007/10/02)
Methylated thiophene-2-carboxylic acids can be readily homologated by treatment with LDA (2 equiv) followed by the addition of carbon-containing electrophiles.
