85895-83-6

Usage

Uses

Used in Flavor and Fragrance Industry:
3,5-dimethylthiophene-2-carbaldehyde serves as a crucial fragrance and flavoring agent, specifically in the production of food and cosmetic products. Its distinct aromatic profile contributes to the creation of desirable scents and tastes, enhancing the sensory experience of these consumer goods.
Used in Pharmaceutical Synthesis:
In the pharmaceutical sector, 3,5-dimethylthiophene-2-carbaldehyde operates as an intermediate in the synthesis of various drugs. Its chemical structure allows for its incorporation into medicinal compounds, potentially leading to the development of new therapeutic agents.
Used in Agrochemical Production:
Similarly, 3,5-dimethylthiophene-2-carbaldehyde is utilized as an intermediate in the synthesis of agrochemicals. Its role in this industry is instrumental in developing products that can protect crops and enhance agricultural yields.
Used in Organic Synthesis and Materials Science:
3,5-dimethylthiophene-2-carbaldehyde also holds potential in the realms of organic synthesis and materials science. Its unique properties make it a valuable component in the development of new materials and chemical processes.
However, it is imperative to exercise caution when handling 3,5-dimethylthiophene-2-carbaldehyde, as it is classified as flammable and can cause skin and eye irritation upon contact. Proper safety measures should be implemented to mitigate these risks.

InChI:InChI=1/C7H8OS/c1-5-3-6(2)9-7(5)4-8/h3-4H,1-2H3

Upstream product

• 5834-16-2 3-methyl-2-thiophenecarboxaldehdye 
• 74-88-4 methyl iodide 
• 616-44-4 3-Methylthiophene 
• 13679-70-4 5-methylthiophene-2-carboxaldehyde 
• 638-00-6 2,4-dimethylthiophene 
• 68-12-2 N,N-dimethyl-formamide 
• 6030-36-0 4-methylthiophene-2-carbaldehyde 
• 98-03-3 thiophene-2-carbaldehyde 

Downstream Products

• 141191-56-2 diethyl (3-methyl-5-benzyloxymethyl-2-thienyl)-methylphosphonate 
• 141191-57-3 diethyl <3-methyl-5-(4-hydroxybenzyl)-2-thienyl>-methyl-phosphonate 
• 679806-34-9 3,5-dimethylthiophene-2-carbonyl chloride 
• 65613-27-6 3,5-dimethyl-2-thiophenecarboxylic acid 

Relevant academic research and scientific papers

Synthesis and photochromic properties of tetrakis(3,5-dimethyl-2-thienyl)- and tetrakis(2,5-dimethyl-3-thienyl)ethylenes

Tetrakis(3,5-dimethyl-2-thienyl)ethylene and tetrakis(2,5-dimethyl-3- thienyl)ethylene were obtained from the corresponding dithienyl ketones by the McMurry reaction. The photochromic properties of the compounds obtained were studied.

Cyclic ketone derivatives and their medical applications

The present invention relates to cyclic ketones represented by the following formula and to drugs in which an effective component is such a cyclic ketone or a pharmacologically acceptable salt thereof.The cyclic ketones of the present invention encourage the production of blood platelets, leukocytes and erythrocytes, and can be employed in the prevention or treatment of cytopaenia brought about by cancer chemotherapy, radiotherapy or drug therapy, or by immunological abnormality, anaemia and the like.

A Thiophene Analogue of Praziquantel, and Related Systems, by Intramolecular Cyclisation of Acyliminium Salts

N--succinimide (7a) and -glutarimide (7b) on reduction with sodium borohydride in methanol at -10 deg C yield the respective hydroxylactams which on treatment with formic acid cyclise via the intermediate acyliminium ions to 4,5,9,9a-tetrahydropyrrolothienopyridin-7-one (9a) and 4,5,8,9,10,10a-hexahydropyridothienopyridin-7-one (9b) respectively.In a similar manner, 4-cyclohexylcarbonyl-1-piperazine-2,6-dione (11) is converted into the thiophene isostere (2) of praziquantel (1).Likewise, formic acid induced cyclisations of the hydroxylactams derived from N-- (16) and N-succinimide (19) furnish 5,6,10,10a-tetrahydropyrrolothienothiazepin-8(9H)-one (18) and 5,6,10,10a-tetrahydropyrrolothienothiazepin-8(9H)-one (21), respectively.

Lithiation of Heterocycles Directed by α-Amino Alkoxides

The addition of heterocyclic aromatic aldehydes to certain lithium dialkylamides gave α-amino alkoxides that were ring-lithiated with butyllithium.Alkylation and hydrolysis provided ring-substituted heterocyclic aromatic aldehydes via a one-pot reaction.The metalation of α-amino alkoxides derived from thiophenecarboxaldehydes, furaldehydes, N-methylpyrrolecarboxaldehydes, and indolecarboxaldehydes was examined.The regioselectivity of the lithiation, was dependent on the heterocycle, the amine component of the α-amino alkoxide, and the metalation conditions.A novel N-methyl metalation of α-amino alkoxides derived from N-methylpyrrole-2-carboxaldehyde and N-methylindole-2-carboxaldehyde was achieved when N,N,N'-trimethylethylenediamine was used as the amine component for in situ formation of the α-amino alkoxides.The novel directed N-methyl lithiations are attributed to an intramolecular TMEDA-like assisted metalation.