65651-80-1

Usage

Uses

Used in Chemical Research and Experimentation:
ETHYL TRANS-3-(1-PYRROLIDINO)ACRYLATE is used as a research compound for its potential to react under various conditions, making it valuable in the development and understanding of chemical reactions and processes. Its semi-volatile nature and high reactivity contribute to its utility in these applications.
Used in Organic Chemistry:
ETHYL TRANS-3-(1-PYRROLIDINO)ACRYLATE is used as a reagent in organic chemistry, where its ethyl group can participate in reactions as a nucleophile or donate electrons, facilitating the synthesis of other compounds and contributing to the advancement of organic chemistry research.
Used in Laboratory Settings:
ETHYL TRANS-3-(1-PYRROLIDINO)ACRYLATE is used as a laboratory chemical, where its properties and reactivity are harnessed for educational purposes and the exploration of chemical reactions. Proper handling and usage under laboratory conditions are essential due to its potential hazards, ensuring the safety of researchers and the integrity of experiments.

InChI:InChI=1/C9H15NO2/c1-2-12-9(11)5-8-10-6-3-4-7-10/h5,8H,2-4,6-7H2,1H3/b8-5+

Upstream product

• 123-75-1 pyrrolidine 
• 623-47-2 propynoic acid ethyl ester 
• 105-37-3 Ethyl propionate 
• 35247-24-6 ethyl 3-oxo-3-(pyrrolidin-1-yl)propanoate 

Downstream Products

• 4105-92-4 triethyl benzene-1,3,5-tricarboxylate 
• 86576-75-2 ethyl 2-formyl-5-phenyl-4-pentenoate 
• 86576-76-3 ethyl 2-formyl-3-phenyl-3-pentenoate 
• 98516-80-4 ethyl 2-formyl-3-phenylpropionate 
• 86576-74-1 ethyl 2,2-dibenzyl-3-oxopropanoate 
• 82957-64-0 1-phenyl-3-(pyrrolidin-1-yl)-1H-pyrrole-2,5-dione 
• 82957-65-1 5-(Phenylimino)-4-(1-pyrrolidinyl)-2(5H)-thiophenon 
• 5562-05-0 4-(4-nitro-phenyl)-pyridine-2,5-dicarboxylic acid diethyl ester 
• 20328-15-8 3-methylisoxazole-4-carboxylic acid ethyl ester 
• 29363-98-2 3-(4-chloro-phenyl)-isoxazole-4-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Solvent-controlled two-step one-pot syntheses of α-X (X = Br or Cl) enamino ketones/esters and 3-(2,5-dioxopyrrolidin-1-yl)acrylate by using terminal carbonyl alkynes

A new two-step one-pot aminobromination/chlorination of carbonyl alkynes has been achievedviaa Michael addition of aliphatic secondary amines and subsequent β-bromination/chlorination of the obtained enamines to afford various α-X (X = Br or Cl) enamino ketones/esters in moderate to good yields. A solvent-controllable protocol has been developed to produce versatile 3-(2,5-dioxopyrrolidin-1-yl)acrylates in moderate yields by using toluene as the solvent and chain alkyl propiolates as alkynyl substrates.

Green H 2 O-Promoted Solvent-Free Synthesis of Enaminocarbonyl Compounds with High Stereoselectivity from Electron-Deficient Terminal Alkynes

A green H 2 O-promoted solvent-free hydroamination of electron-deficient terminal alkynes with amines has been developed. All secondary amines, including aliphatic and aromatic amines, gave the corresponding (E)-enamines in good to excellent yi

Ir-catalyzed chemoselective reduction of β-amido esters: A versatile approach to β-enamino esters

The conversion of β-amido esters to β-enamino esters is an indispensable step for some synthetic approaches to alkaloids and related medicines. Known methods for such transformation are not only stepwise, but also proceed with low atom-efficiency. Herein, we report a direct and versatile approach that features the Ir-catalyzed chemoselective reduction of β-amido esters with 1,1,3,3-tetramethyldisiloxane (TMDS). In addition, a lack of some signals was observed in the 13C NMR spectra of some alicyclic β-enamino esters. This revealed a longstanding existing but being ignored phenomenon in the literature.

PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS

Compounds of Formula (I), Formula (II), Formula (III), Formula (IV), Formula (V), Formula (VI), Formula (VII), Formula (VIII), and methods of use as lnterleukin-1 Receptor Associated Kinase (IRAK4) inhibitors are described herein.

A field-based disparity analysis of new 1,2,5-oxadiazole derivatives endowed with antiproliferative activity

A series of 1,2,5-oxadiazoles were synthesized as new potential antiproliferative agents. The in vitro cytotoxic activity evaluation of title compounds through MTT assay revealed that some of them showed significant activity against the HCT-116 cancer cell line. The field-based disparity analysis provided indications about the electrostatic, hydrophobic, and shape features underlying the cytotoxicity, suggesting that increasing the negative electrostatic field on the heterocyclic core of the structure has positive effects on the activity. The structure–activity relationships (SAR) around a particular compound can be explained allowing for a structural rationale for the differences in activity. The SAR provided by this series of compounds can be exploited to carry out further lead optimization.

Discovery of potent and selective pyrazolopyrimidine Janus kinase 2 inhibitors

The discovery of somatic Jak2 mutations in patients with chronic myeloproliferative neoplasms has led to significant interest in discovering selective Jak2 inhibitors for use in treating these disorders. A high-throughput screening effort identified the p

A facile approach to substituted acrylates by regioselective and stereoselective addition of thiols and amines to an alkynyl ester in water

Water-promoted hydrothiolation and hydroamination of ethyl propiolate leading to highly regioselective and stereoselective formation of thioacrylates and β-enamino esters in excellent yields, by a simple, efficient, and environmentally friendly reaction p

3-Aryl-4-isothiazolecarboxylic acid and 3-aryl-4-isoxazolecarboxylic acid derivatives and their use as herbicides

Carboxylic acid derivatives having the formula STR1 have been found to be effective herbicides. They are especially effective when applied as a pre-emergent herbicide.

3-Aryl-4-isoxazolecarboxylic acids as plant growth regulants

3-Aryl-4-isothiazolecarboxylic acids as well as 3-aryl-4-isoxazolecarboxylic acids have been found to be effective plant growth regulants especially when applied to soybean plants.