204503-25-3

Usage

Physical state

Colorless liquid
1-bromo-4-[(3-methylbut-2-en-1-yl)oxy]benzene is a liquid at room temperature and is colorless in appearance.

Molecular structure

Benzene ring with a bromine atom at the 1 position and a 3-methylbut-2-en-1-yl group attached to the 4 position through an oxygen atom
The compound's structure consists of a benzene ring, which is a six-carbon ring with alternating single and double bonds. A bromine atom is attached to the first carbon of the ring, and a 3-methylbut-2-en-1-yl group (an allyl group with a methyl group) is connected to the fourth carbon through an oxygen atom, forming an ether linkage.

Functional groups

Bromine atom, allyl group, and ether linkage
The presence of these functional groups contributes to the compound's reactivity and its use as an intermediate in organic synthesis.

Applications

Intermediate in the synthesis of pharmaceuticals and other organic compounds
Due to its unique chemical structure, 1-bromo-4-[(3-methylbut-2-en-1-yl)oxy]benzene is used as a building block in the production of various pharmaceuticals and other organic compounds.

Synonyms

p-bromoallyloxybenzene and p-bromoallyl phenyl ether
The compound is also known by these alternative names, which describe its structure and functional groups.

Reactivity

Useful in various organic synthesis processes
The compound's unique structure and functional groups make it a versatile intermediate for use in a range of organic synthesis reactions.

Hazards

Potential health and environmental risks
As with many organic compounds, 1-bromo-4-[(3-methylbut-2-en-1-yl)oxy]benzene may pose certain health and environmental risks, and proper handling and disposal procedures should be followed.

Upstream product

• 106-41-2 4-bromo-phenol 
• 870-63-3 prenyl bromide 
• 115-18-4 2-methyl-3-buten-2-ol 
• 556-82-1 3-methyl-2-buten-1-ol 

Downstream Products

• 847830-10-8 (4-[(3-METHYLBUT-2-EN-1-YL)OXY]PHENYL)BORANEDIOL 
• 269410-18-6 4,4,5,5-Tetramethyl-2-(4-{[(E)-3-methyl-1-butenyl]oxy}phenyl)-1,3,2-dioxaborolane 
• 61370-75-0 3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-6-carboxaldehyde 
• 464194-68-1 himanimide B 
• 464895-13-4 3-benzyl-4-[4-(3-methylbut-2-enoxy)phenyl]-1H-pyrrole-2,5-dione 
• 1256724-50-1 1-(3-methylbut-2-enyloxy)-4-(3-phenylprop-1ynyl)benzene 
• 464189-92-2 1-hydroxy-3-benzyl-4-[4-(3-methyl-2-butenyloxy)phenyl]-1H-pyrrol-2,5-dione 
• 1030374-49-2 3-benzyl-4-[4-(3-methyl-2-butenyloxy)phenyl]furan-2,5-dione 
• 656830-26-1 1-hydroxy-3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]-1H-pyrrol-2,5-dione 
• 656830-25-0 3-isobutyl-4-{4-[(3-methyl-2-butenyl)oxy]phenyl}-1H-pyrrole-2,5-dione 
• 656830-24-9 3-[4-(3-methylbut-2-enyloxy)phenyl]-4-isobutylfuran-2,5-dione 
• 935525-81-8 1-benzyl-3-isobutyl-4-[4-(3-methylbut-2-enyloxy)phenyl]pyrrole-2,5-dione 

Relevant academic research and scientific papers

MAP4K4 INHIBITORS

This invention relates to compounds that may be useful as inhibitors of Mitogen-activated Protein Kinase Kinase Kinase Kinase-4 (MAP4K4). The invention also relates to the use of these compounds, for example in a method of treatmentof cardiac conditions.In particular, the present invention relates to compounds of formula (I):

Base-Promoted Radical Azofluoromethylation of Unactivated Alkenes

The base-induced reaction of aryl diazonium salts with commercially available CF3SO2Na/CF2HSO2Na allows for the generation of the corresponding diazene radicals along with fluoromethyl radicals. The addition of fluoromethyl radicals to alkenes with subsequent diazene trapping provides the azofluoromethylation products in good to excellent yields. This metal-free method under mild reaction conditions has broad functional group compatibility and is applicable in the late-stage modification of various natural products and bioactive molecules.

MAP4K4 INHIBITORS

This invention relates to pyrrolopyrimidine comprising compounds that may be useful as inhibitors of Mitogen-activated Protein Kinase Kinase Kinase Kinase-4 (MAP4K4). The invention also relates to the use of these pyrrolopyrimidine comprising compounds, f

A dehydrogenative diels-alder reaction of prenyl derivatives with 2,3-dichloro-5,6-dicyanobenzoquinone

An efficient dehydrogenative Diels-Alder (DHDA) reaction of prenyl derivatives with 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) has been developed under mild conditions, leading to a series of cyclohexene derivatives with good to excellent yields and excellent diastereoselectivity.

N-(1-HYDROXY-3-(PYRROLIDINYL)PROPAN-2-YL)PYRROLIDINE-3-CARBOXAMIDE DERIVATIVES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS

Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and compounds I for use to treat or prevent diseases or conditions associated with the enzyme glucosylceramide synthase (GCS).

Iron-catalyzed carbonylation as a key step in the short and efficient syntheses of himanimide A and B

Isn't it iron-ic: An iron-catalyzed [2+1+1+1]-annulation strategy is used for the construction of five-membered maleimides, which are building blocks for naturally occurring himanimides A and B.

Total synthesis of (±)-camphorataimides and (±)-himanimides by NaBH4/Ni(OAc)2 or Zn/AcOH stereoselective reduction

Maleic anhydride 1 of Antrodia camphorate, which can be isolated from Chinese herbal medicine, is achieved in which the longest linear sequence is only five steps, in 40% overall yield from commercially available succinic anhydride. The crucial antrodimid

A concise synthesis of maleic anhydride and maleimide natural products found in Antrodia camphorata

Recently, the natural products maleic anhydride 1 and maleimides 2 and 3 have been isolated from the mycelium of Antrodia Camphorata, each displaying activity in LLC cell lines. We describe a concise synthesis of each of these natural compounds utilizing C-C cross-coupling methodology, namely, the Negishi and Suzuki reactions. This efficient and high yielding synthesis is convergent lending itself to production of medicinal analogues.

Synthesis and biological evaluation of himanimide C and unnatural analogues

(Chemical Equation Presented) Recently isolated himanimide C (1) can be prepared via a short, flexible, and stereoselective synthesis using a copper-mediated tandem vicinal difunctionalization of dimethyl acetylenedicarboxylate (DMAD, 8) as a key step. Th

Regioselectivity in the ene reaction of singlet oxygen with ortho-prenylphenol derivatives

The ene reaction of singlet oxygen with prenylated dihydroxyacetophenones led to the 2-hydroperoxy-3-methylbut-3-enyl derivatives as the major product. This original regioselectivity outlined a new effect, in competition with the previously established la