65702-08-1

Basic information

• Product Name: 1-(6-Methyl-2-pyridyl)acetone
• Synonyms: 1-(6-Methyl-2-pyridyl)acetone;1-(6-methylpyridin-2-yl)acetone(SALTDATA: FREE);1-(6-methylpyridin-2-yl)acetone;1-(6-methylpyridin-2-yl)propan-2-one
• CAS NO: 65702-08-1
• Molecular Formula: C₉H₁₁NO
• Molecular Weight: 149.19
• Mol File: 65702-08-1.mol

Chemical Properties

• Boiling Point: 220.5°C at 760 mmHg
• Flash Point: 92.1°C
• Appearance: /
• Density: 1.026g/cm³
• Vapor Pressure: 0.113mmHg at 25°C
• Refractive Index: 1.508
• CAS DataBase Reference: 1-(6-Methyl-2-pyridyl)acetone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(6-Methyl-2-pyridyl)acetone(65702-08-1)
• EPA Substance Registry System: 1-(6-Methyl-2-pyridyl)acetone(65702-08-1)

Safety Data

• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-39
• WGK Germany: 3
• Hazardous Substances Data: 65702-08-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
1-(6-Methyl-2-pyridyl)acetone is used as a reagent in pharmaceutical research for the synthesis of various pharmaceuticals. Its unique chemical structure allows for the creation of new compounds with potential therapeutic applications.
Used in Agrochemical Synthesis:
In the agrochemical industry, 1-(6-Methyl-2-pyridyl)acetone is used as a precursor for the synthesis of various agrochemicals. Its chemical properties make it suitable for the development of compounds that can be used in the agricultural sector for pest control and crop protection.
Used in Organic Synthesis:
1-(6-Methyl-2-pyridyl)acetone is utilized as a key intermediate in organic synthesis, where it can be employed to produce a wide range of chemical products. Its versatility in chemical reactions contributes to its importance in the field of organic chemistry.

InChI:InChI=1/C9H11NO/c1-7-4-3-5-9(10-7)6-8(2)11/h3-5H,6H2,1-2H3

Upstream product

• 108-48-5 2,6-dimethylpyridine 
• 875250-74-1 2,6-lutidyllithium 
• 127-19-5 N,N-dimethyl acetamide 
• 79-20-9 acetic acid methyl ester 
• 18368-63-3 6-chloro-2-picoline 
• 67-64-1 acetone 

Downstream Products

• 71271-62-0 1-methyl-2-(6-methyl-pyridin-2-yl)-ethylamine 
• 5397-28-4 2-Methyl-6-propyl-pyridin 
• 51487-37-7 2-isopropyl-6-methylpyridine 
• 55267-91-9 1-(6-methyl-2-piperidyl)propan-2-ol 
• 83285-66-9 cis-1-(6-methyl-2-piperidyl)propan-2-one 
• 65266-41-3 2-methyl-6-propylpiperidine 
• 1282608-32-5 C₁₇H₂₀N₂ 
• 1448154-47-9 2-methyl-6-(2-methyl-5-phenyl-1H-pyrrol-3-yl)pyridine 
• 66120-51-2 1-(6-methylpyridin-2-yl)propan-2-ol 

Relevant articles and documents

Chemoenzymatic Asymmetric Synthesis of Pyridine-Based α-Fluorinated Secondary Alcohols

Fluoro-substituted and heteroaromatic compounds are valuable intermediates for a variety of applications in pharma- and agrochemistry and synthetic chemistry. This study investigates the chemoenzymatic preparation of chiral alcohols bearing a heteroaromatic ring with an increasing degree of fluorination in α-position. Starting from readily available picoline derivatives prochiral α-halogenated acyl moieties were introduced with excellent selectivity and 64–95 % yield. The formed carbonyl group was subsequently reduced to the corresponding alcohols using the alcohol dehydrogenase from Lactobacillus kefir, yielding an enantiomeric excess of 95–>99 % and up to 98 % yield.

Zheda-phos for general α-monoarylation of acetone with aryl chlorides

A new, readily available, and air-stable monophosphine ligand, i.e., Zheda-Phos, has been developed for the general and highly effective palladium-catalyzed monoarylation of acetone with aryl chlorides. The reaction rate is of first-order dependence with the aryl chloride. Copyright

The Wolff-Kishner Reduction of 2-Acetonyl Pyrazines and Pyridines. A Novel Rearrangement

Wolff-Kishner reduction of 1-(6-methylpyrazin-2-yl)-2-propanone leads to the formation of 2-isopropyl-6-methylpyrazine (2a), in addition to the expected 6-methyl-2-n-propylpyrazine.The by-product 2a is suggested to arise via a spirocyclopropylidene aza-anion, which serves as a conduit between the initial less-stable secondary 1-(2-pyrazinyl)-2-propyl carbanion and the more stable primary 2-(2-pyrazinyl)-1-propyl carbanion.Similar results were observed for the 1-(3-methylpyrazin-2-yl) and 1-(6-methylpyridin-2-yl)-2-propanones.The extent of by-product formation diminished in the pyridine ring system.Electrophilic activation of the ring appears essential since the benzene ring analog phenylacetone gave no detectable cumene under identical reaction conditions.