65729-81-9Relevant academic research and scientific papers
The Use of a Mannitol-Derived Fused Oxacycle as a Combinatorial Scaffold
Timmer, Mattie S. M.,Verdoes, Martijn,Sliedregt, Leo A. J. M.,Van Der Marel, Gijsbert A.,Van Boom, Jacques H.,Overkleeft, Herman S.
, p. 9406 - 9411 (2007/10/03)
An efficient and high-yielding solid-phase synthesis of a small library of compounds containing a cis-fused pyranofuran structural motive is descibed. With use of the cheap and readily available D-(+)-mannitol, a highly functionalized sugar template was synthesized and immobilized on a solid support via an olefinic linker. Modification of this two-point molecular scaffold and subsequent ring-closing metathesis/cleavage gave access to a series of functionalized conformationally constrained fused oxacycles.
Synthesis of homo-C-D4T and homo-C-thymidine
Doboszewski, Bogdan
, p. 1049 - 1052 (2007/10/03)
β-C-Vinyl glycoside of D-arabinofuranose was converted to the β-C- hydroxymethyl glycoside 12 which was condensed with N-3-benzoyl thymine under Mitsunobu conditions to furnish homo-C-analog 14 of the 2',3'-dideoxy-2',3'- didehydrothymidine (D4T). Synthesis of the homo-C-thymidine 18 was accomplished by the same procedure from compound 15.
