65731-18-2Relevant academic research and scientific papers
Selective Dehydrogenative Acylation of Enamides with Aldehydes Leading to Valuable β-Ketoenamides
Liu, Rui-Hua,Shen, Zhen-Yao,Wang, Cong,Loh, Teck-Peng,Hu, Xu-Hong
, p. 944 - 949 (2020/02/15)
We have presented a unique example of dehydrogenative acylation of enamides with aldehydes enabled by an earth-abundant iron catalyst. The protocol provides the straightforward access to valuable β-ketoenamides with ample substrate scope and excellent functional group tolerance. Notably, distinct C-H acylation of enamide rather than at N-H moiety site occurs with absolute Z-selectivity was observed. Late-stage modifications of complex molecules and versatile synthetic utility of β-ketoenamides further highlight the practicability of this transformation.
Iodine-mediated oxidative dehydrogenation of β-acylamino ketones for the highly stereoselective synthesis of (Z)-β-keto-enamides
Chang, Hong-Hong,Hu, Fei,Gao, Wen-Chao,Liu, Tao,Li, Xing,Wei, Wen-Long,Qiao, Yan
supporting information, p. 1592 - 1596 (2016/06/14)
An iodine-mediated oxidative dehydrogenation of β-acylamino ketones has been developed for the synthesis of β-ketoenamides in moderate to good yields. Only Z-isomers are accessed due to the intramolecular H-bonding interaction in the HI-elimination step.
Preparation of highly substituted (β-acylamino)acrylates via iron-catalyzed alkoxycarbonylation of N-vinylacetamides with carbazates
Ding, Ran,Zhang, Qiu-Chi,Xu, Yun-He,Loh, Teck-Peng
supporting information, p. 11661 - 11664 (2015/05/20)
An efficient iron(ii)-catalyzed alkoxycarbonylation reaction between N-vinylacetamides and carbazates is reported. The corresponding useful highly substituted (β-acylamino)acrylates could be obtained in reasonable to good yields and stereoselectivity under mild reaction conditions. This journal is
