91875-48-8Relevant articles and documents
Facile one-pot multicomponent synthesis of β-acetamido ketones with Amberlyst-15 as heterogeneous catalyst
Das, Biswanath,Reddy, Kongara Ravinder
, p. 3109 - 3111 (2006)
The one-pot multicomponent coupling of an aromatic aldehyde, an enolizable ketone or keto ester, acetonitrile, and acetyl chloride at room temperature in the presence of Amberlyst-15 as catalyst affords β-acetamido ketones in high yields. The inexpensive catalyst works under heterogeneous conditions and can be readily reused.
SBA-15-Pr-SO3H: An efficient, environment friendly and recyclable heterogeneous nanoreactor catalyst for the one-pot multicomponent synthesis of β-acetamido ketones
Bahrami, Kiumars,Khodaei, Mohammad M.,Fattahpour, Peyman
, p. 167 - 172 (2015)
SBA-15-Pr-SO3H catalyzes the multi-component condensation of aromatic aldehydes, ketones and acetonitrile in the presence of acetyl chloride at 80°C to afford β-acetamido ketones in excellent yields. The catalyst can be recovered and recycled f
A SiCl4-ZnCl2 induced general, mild and efficient one-pot, three-component synthesis of β-amido ketone libraries
Salama, Tarek A.,Elmorsy, Saad S.,Khalil, Abdel-Galel M.,Ismail, Mohamed A.
, p. 6199 - 6203 (2007)
A general, mild and efficient protocol for the synthesis of β-amido ketone libraries was achieved utilizing tetrachlorosilane and zinc chloride in dichloromethane at ambient temperature via a one-pot, three-component condensation of various aldehydes, ket
Trifluoromethanesulfonic acid promoted Dakin-West reaction: An efficient and convenient synthesis of β-acetamido ketones
Kumbhare, Ravindra M,Sridhar, Madabhushi
, p. 495 - 500 (2012)
Trifluoromethanesulfonic acid promoted efficient condensation of an aromatic aldehyde with an acetophenone and acetonitrile in the presence of acetylchloride as an activator producing β-acetamido carbonyl compounds is described. [Figure not available: see
Heteropoly acids as solid green Bronsted acids for a one-pot synthesis of β-acetamido ketones by Dakin-West reaction
Rafiee, Ezzat,Tork, Fariba,Joshaghani
, p. 1221 - 1226 (2006)
An efficient improved procedure for the synthesis of β-acetamido ketones has been developed by a heteropoly acid (HPA) catalyzed three-component coupling protocol. The present methodology offers several advantages such as excellent yields, simple procedur
An efficient and eco-friendly solvent-free synthesis of β-acetamido ketones using l-proline as a green and reusable catalyst
Roshani,Allameh,Darkooti
, p. 1934 - 1936 (2013)
A simple and efficient catalytic protocol for the synthesis of β-acetamido ketones via the one-pot, four component condensation of aryl aldehydes, enolizable aryl ketones, acetyl chloride and acetonitrile using L-proline is reported. The present method of
One-pot four-component Dakin-West synthesis of β-acetamido ketones catalyzed by a vanadium-substituted heteropolyacid
Tayebee, Reza,Tizabi, Shima
, p. 923 - 932 (2012)
The multicomponent condensation of an aryl aldehyde, acetyl chloride, acetonitrile, and enolizable ketone as one-pot synthesis of β-acetamido ketones in high yields was investigated using commercial, non-corrosive, and environmentally benign Keggin and We
One-pot synthesis of β-acetamido-β-(Phenyl) propiophenone using zno/carbon nanocomposites
Krithiga, Thangavelu,Salla, Sunitha,Jayabalan, Karthikeyan,Kumar, Jagadeesan Aravind
, p. 213 - 219 (2021/03/04)
Aim and Objectives: The focus of the present work is to synthesize ZnO/C composite using dextrose as carbon source by combustion method and study the comparative evaluation on one-pot synthesis of β-acetamido-β-(phenyl) propiophenone over ZnO nanoparticles and ZnO/C composite catalyst. Materials and Methods: The ZnO nanoparticles has been synthesized by sol-gel method using zinc nitrate and NaOH and ZnO/Carbon composites by combustion method using zinc nitrate and dextrose as carbon source. The resulting gel was placed in a preheated muffle furnace at 400oC. The solution boils and ignites with a flame. On cooling highly amorphous powder of ZnO/Carbon composite is obtained. Results: The XRD patterns reveal the hexagonal phase with Wurtzite structure and the nanocrystalline nature of the catalysts. The SEM image of ZnO/C composite showed that it contains spherical particles with an average size of 41 nm. The average particle size of the composite was around 60nm by DLS method. The catalytic activity of the ZnO/Carbon composites has been analyzed by one-pot four-component condensation of benzaldehyde, acetophenone, acetyl chloride and acetonitrile. The feed molar ratio of 1:1 (Bz:AP) and catalyst loading of 30 mol% is found to be the optimal condition for β-acetamido ketone conversion over ZnO/carbon composite. Conclusion: The substantial catalytic activity of the synthesized ZnO/C composite materials was tested by one-pot four-component condensation of benzaldehyde (Bz), acetophenone (AP), acetyl chloride (AC) and acetonitrile (AN) which showed a high β-acetamido ketone conversion under the optimized reaction conditions. It has also been found that the catalyst is very stable and reusable.
Studying catalytic activity of ternary mixed-metal Keggin H7SiV3W9O40 as a versatile acid catalyst for the synthesis of β-acetamido ketones
Tayebee, Reza,Pejhan, Akbar
, (2019/12/03)
One-pot four-component condensation of an aromatic aldehyde with an enolisable ketone and acetyl chloride is investigated in the presence of H7SiV3W9O40 in acetonitrile. The prepared catalyst was characterized by standard techniques such as XRD, SEM, and FT-IR to verify the Keggin structure of nanocatalyst. Furthermore, findings revealed a very good catalytic activity for the applied vanadium substituted heteropolyacid in this acid catalyzed condensation reaction. A series of Keggin Si and V-substituted heteropolyacids were compared for the synthesis of β-acetamido-β-(4-chlorophenyl)propiophenone, which showed a better catalytic activity for H7SiV3W9O40 and H4SiW12O40 than the lacunary and mixed metal Keggin H4SiW9Mo3O40 and H5SiW9Mo2VO40. In addition, effect of the nitrilating agent was also demonstrated in this catalytic system and findings show less proficiency for PhCN compared to acetonitrile. Moreover, propiophenone as an α-substituted enolisable ketone was reacted with some aromatic aldehydes and the anti isomer is detected as the major diastereomer. Therefore, H7SiV3W9O40 can be introduced as a new effective, inexpensive, and eco-friendly catalyst for the introduced four-component condensation reaction.
Recyclable magnetic copper ferrite nanoparticle catalyzed one-pot four-component Dakin-West reaction: Efficient synthesis of β-acetamido ketones
Saeidian, Hamid,Eraghi, Zahra,Naseri, Hamed,Khajeh, Saleh Vahdati,Ahmadi, Leila
, p. 587 - 593 (2018/06/26)
CuFe2O4 nanoparticles were prepared by co-precipitation method. After the characterization of nanoparticles by XRD, SEM, EDS and TEM, their catalyst activity was investigated in the synthesis of β-acetamido ketones. CuFe2O
