1194-64-5

Basic information

• Product Name: 2-CHLORO-6-METHYLBENZALDEHYDE
• Synonyms: 2-CHLORO-6-METHYLBENZALDEHYDE;3-Chloro-2-formyltoluene;6-Chloro-2-methylbenzaldehyde;3-Chloro-2-formyltoluene, 6-Chloro-o-tolualdehyde;2-Chloro-6-methylbenzaldehyde 96%
• CAS NO: 1194-64-5
• Molecular Formula: C₈H₇ClO
• Molecular Weight: 154.59
• Product Categories: Aldehydes;C7;Carbonyl Compounds
• Mol File: 1194-64-5.mol
• Article Data: 13

Chemical Properties

• Melting Point: 31 °C
• Boiling Point: 74 °C
• Flash Point: 74°C/0.4mm
• Appearance: white crystalline powder
• Density: 1.195 g/cm³
• Vapor Pressure: 0.057mmHg at 25°C
• Refractive Index: 1.575
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive: Air Sensitive
• CAS DataBase Reference: 2-CHLORO-6-METHYLBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-6-METHYLBENZALDEHYDE(1194-64-5)
• EPA Substance Registry System: 2-CHLORO-6-METHYLBENZALDEHYDE(1194-64-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 1194-64-5(Hazardous Substances Data)

Usage

General Description

2-Chloro-6-methylbenzaldehyde is a chemical compound with the molecular formula C8H7ClO. It is a pale yellow liquid with a strong, sweet, floral odor. This chemical is primarily used as an intermediate in the production of various pharmaceuticals, agrochemicals, and other organic compounds. It is also employed as a flavoring agent in food products and as a fragrance ingredient in perfumes and cosmetics. Additionally, 2-Chloro-6-methylbenzaldehyde is used in the synthesis of many other organic compounds, including dyes, pigments, and other specialty chemicals. However, it is important to handle this chemical with care, as it can be harmful if ingested, inhaled, or absorbed through the skin, and it may also cause irritation to the eyes, skin, and respiratory system.

InChI:InChI=1/C8H7ClO/c1-6-3-2-4-8(9)7(6)5-10/h2-5H,1H3

Upstream product

• 6575-09-3 2-chloro-6-methyl-benzonitrile 
• 35490-90-5 2-amino-6-chlorobenzaldehyde 
• 676-58-4 methylmagnesium chloride 
• 32347-02-7 2-chlorobenzalaniline 
• 917-54-4 methyllithium 
• 529-20-4 2-methylphenyl aldehyde 
• 89-98-5 2-chloro-benzaldehyde 
• 77206-89-4 (2-chloro-6-methylphenyl)methanol 
• 387-45-1 2-chloro-6-fluorobenzaldehyde 
• 100-52-7 benzaldehyde 
• 75-17-2 formaldoxime 
• 87-63-8 2-chloro-6-methylaniline 
• 74-88-4 methyl iodide 

Downstream Products

• 21327-86-6 2-chloro-6-methylbenzoic acid 
• 89894-44-0 2-chloro-6-methylbenzoyl chloride 
• 259733-13-6 2-(bromomethyl)-1-chloro-3-methylbenzene 
• 1200397-45-0 ethyl 2-(3-(2-chloro-6-methylbenzyloxy)phenyl)acetate 
• 1200397-26-7 2-(3-(2-chloro-6-methylbenzyloxy)phenyl)acetic acid 

Relevant articles and documents

Monodentate Transient Directing Group Enabled Pd-Catalyzed Ortho-C-H Methoxylation and Chlorination of Benzaldehydes

We report Pd-catalyzed ortho-C-H methoxylation and chlorination of benzaldehydes by employing monodentate transient directing groups (TDGs) as an alternative strategy to bidentate TDGs. More importantly, a single crystal of benzaldehyde imine ortho-cyclopalladium intermediate was successfully obtained, and its structure was unambiguously determined by X-ray diffraction, which clearly showed that it was a binuclear palladium species bridged by a pyridone ligand. The utility of this approach was further demonstrated through the synthesis of key intermediates of natural products and drugs.

IBX works efficiently under solvent free conditions in ball milling

IBX (2-iodoxybenzoic acid), discovered in 1893, is an oxidant in synthetic chemistry whose extensive use is impeded by its explosiveness at high temperature and poor solubility in common organic solvents except DMSO. Since the discovery of Dess-Martin Periodinane in 1983, several modified IBX systems have been reported. However, under ball milling conditions, IBX works efficiently with various organic functionalities at ambient temperature under solvent free conditions. Also, the waste IBA (2-iodosobenzoic acid) produced from the reactions was in situ oxidized to IBX in the following step using oxone and thus reused for multiple cycles by conserving its efficiency (only ～6% loss after 15 cycles). This work describes an overview of a highly economical synthetic methodology which overcomes the problems of using IBX, efficiently in gram scale and in a non-explosive way. This journal is the Partner Organisations 2014.

1,2-BIS-(SUBSTITUTED-PHENYL)-2-PROPEN-1-ONES AND PHARMACEUTICAL COMPOSITIONS THEREOF

The invention relates to compounds, pharmaceutical compositions and methods of using compounds of the general formula (I), or its pharmaceutically acceptable salt or ester, wherein the substituents are defined in the application.