1194-64-5

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-6-methylbenzaldehyde is used as an intermediate in the production of various pharmaceuticals, contributing to the development of new drugs and enhancing the efficacy of existing ones.
Used in Agrochemical Industry:
This chemical compound is also utilized as an intermediate in the synthesis of agrochemicals, playing a crucial role in the development of effective pesticides and other agricultural products.
Used in Flavoring and Fragrance Industry:
2-Chloro-6-methylbenzaldehyde is employed as a flavoring agent in food products, imparting a unique taste and aroma, and as a fragrance ingredient in perfumes and cosmetics, adding a distinct scent to these products.
Used in Dye and Pigment Industry:
Furthermore, this chemical is used in the synthesis of dyes, pigments, and other specialty chemicals, contributing to the creation of vibrant colors and high-quality materials for various applications.
However, it is essential to handle 2-chloro-6-methylbenzaldehyde with care, as it can be harmful if ingested, inhaled, or absorbed through the skin, and may cause irritation to the eyes, skin, and respiratory system.

InChI:InChI=1/C8H7ClO/c1-6-3-2-4-8(9)7(6)5-10/h2-5H,1H3

Upstream product

• 89-98-5 2-chloro-benzaldehyde 
• 74-88-4 methyl iodide 
• 75-17-2 formaldoxime 
• 87-63-8 2-chloro-6-methylaniline 
• 100-52-7 benzaldehyde 
• 6575-09-3 2-chloro-6-methyl-benzonitrile 
• 35490-90-5 2-amino-6-chlorobenzaldehyde 
• 676-58-4 methylmagnesium chloride 
• 32347-02-7 2-chlorobenzalaniline 
• 917-54-4 methyllithium 
• 387-45-1 2-chloro-6-fluorobenzaldehyde 
• 77206-89-4 (2-chloro-6-methylphenyl)methanol 
• 529-20-4 2-methylphenyl aldehyde 

Downstream Products

• 134271-36-6 (2-chloro-3-methylphenyl)(2-chlorophenyl)methanol 
• 134271-35-5 bis(2-chloro-6-methylphenyl)methanol 
• 21327-86-6 2-chloro-6-methylbenzoic acid 
• 89894-44-0 2-chloro-6-methylbenzoyl chloride 
• 259733-13-6 2-(bromomethyl)-1-chloro-3-methylbenzene 

Relevant academic research and scientific papers

Monodentate Transient Directing Group Enabled Pd-Catalyzed Ortho-C-H Methoxylation and Chlorination of Benzaldehydes

We report Pd-catalyzed ortho-C-H methoxylation and chlorination of benzaldehydes by employing monodentate transient directing groups (TDGs) as an alternative strategy to bidentate TDGs. More importantly, a single crystal of benzaldehyde imine ortho-cyclopalladium intermediate was successfully obtained, and its structure was unambiguously determined by X-ray diffraction, which clearly showed that it was a binuclear palladium species bridged by a pyridone ligand. The utility of this approach was further demonstrated through the synthesis of key intermediates of natural products and drugs.

Pd-Catalyzed, ortho C-H Methylation and Fluorination of Benzaldehydes Using Orthanilic Acids as Transient Directing Groups

The direct, Pd-catalyzed ortho C-H methylation and fluorination of benzaldehydes have been accomplished using commercially available orthanilic acids as transient directing groups. In these reactions, the 1-fluoro-2,4,6-trimethylpyridinium salts can be either a bystanding F+ oxidant or an electrophilic fluorinating reagent. An X-ray crystal structure of a benzaldehyde ortho C-H palladation intermediate was obtained using triphenylphosphine as the stabilizing ligand.

IBX works efficiently under solvent free conditions in ball milling

IBX (2-iodoxybenzoic acid), discovered in 1893, is an oxidant in synthetic chemistry whose extensive use is impeded by its explosiveness at high temperature and poor solubility in common organic solvents except DMSO. Since the discovery of Dess-Martin Periodinane in 1983, several modified IBX systems have been reported. However, under ball milling conditions, IBX works efficiently with various organic functionalities at ambient temperature under solvent free conditions. Also, the waste IBA (2-iodosobenzoic acid) produced from the reactions was in situ oxidized to IBX in the following step using oxone and thus reused for multiple cycles by conserving its efficiency (only ～6% loss after 15 cycles). This work describes an overview of a highly economical synthetic methodology which overcomes the problems of using IBX, efficiently in gram scale and in a non-explosive way. This journal is the Partner Organisations 2014.

PHARMACEUTICAL COMPOSITION AND PROCESS

There is provided a formulation comprising N-(2-chloro-6-methylbenzoyl)-4- [(2,6-dichlorobenzoyl)amino]-L-phenylalanine-2(diethylamino)ethyl ester and poloxamer 188 which is manufactured by a hot melt process.

1,2-BIS-(SUBSTITUTED-PHENYL)-2-PROPEN-1-ONES AND PHARMACEUTICAL COMPOSITIONS THEREOF

The invention relates to compounds, pharmaceutical compositions and methods of using compounds of the general formula (I), or its pharmaceutically acceptable salt or ester, wherein the substituents are defined in the application.

NITROGENOUS HETEROCYCLIC DERIVATIVE HAVING 2,6-DISUBSTITUTED STYRYL

The invention provides a novel nitrogen-containing heterocyclic derivative having 2,6-disubstituted styryl and a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the nitrogen-containing heterocyclic derivative and a pharmaceutically acceptable salt thereof, in particular, a pharmaceutical composition effective as a sodium channel inhibitor, having an excellent analgesic action especially on neuropathic pain with minimized side effects.

Substituted 1-(4-aminophenyl)pyrazoles and their use as anti-inflammatory agents

1-(4-aminophenyl)pyrazoles optionally substituted on the 3- and 5-positions of the pyrazole ring and on the amino group at the 4-position of the phenyl ring are disclosed and described, which pyrazoles inhibit IL-2 production in T-lymphocytes.

Two efficient methods for the preparation of 2-chloro-6-methylbenzoic acid

Two efficient methods for the preparation of 2-chloro-6-methylbenzoic acid were developed: one based on nucleophilic aromatic substitution and the other based on carbonylation. In the first approach, 2-chloro-6-fluorobenzaldehyde was converted to its n-butylimine, then treated with 2 equiv of methylmagnesium chloride in THF to give, after hydrolysis, 2-chloro-6-methylbenzaldehyde. Subsequent oxidation of this compound gave the title compound in 85% overall yield. In the second approach, 3-chloro-2-iodotoluene was efficiently carbonylated in methanol to give methyl 2-chloro-6-methylbenzoate, which after hydrolysis afforded the title compound in 94% yield (84% yield after recrystallization). The carbomethoxylation proceeded smoothly even at a high substrate-to-Pd ratio of 10 000. Both methods do not require isolation of intermediates and are suitable for the preparation of kilogram quantities of 2-chloro-6-methylbenzoic acid.

N-aroylphenylalanine derivative VCAM-1 inhibitors

Compounds of the formula: are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related to the binding of VCAM-1 to cells expr

Thioamide derivatives

It has been discovered that compounds of the formula: and the pharmaceutically acceptable salts and esters thereof wherein X and Y are as defined below, inhibit the binding of VCAM-1 to VLA-4 and are useful in treating inflammation associated with chronic inflammatory diseases such as rheumatoid arthritis (RA), multiple sclerosis, (MS), asthma, and inflammatory bowel disease (I BD).