65766-74-7Relevant academic research and scientific papers
Aryl piperazinyl ureas as inhibitors of fatty acid amide hydrolase (FAAH) in rat, dog, and primate
Keith, John M.,Apodaca, Rich,Tichenor, Mark,Xiao, Wei,Jones, William,Pierce, Joan,Seierstad, Mark,Palmer, James,Webb, Michael,Karbarz, Mark,Scott, Brian,Wilson, Sandy,Luo, Lin,Wennerholm, Michelle,Chang, Leon,Brown, Sean,Rizzolio, Michele,Rynberg, Raymond,Chaplan, Sandra,Breitenbucher, J. Guy
supporting information, p. 823 - 827,5 (2020/09/15)
A series of aryl piperazinyl ureas that act as covalent inhibitors of fatty acid amide hydrolase (FAAH) is described. A potent and selective (does not inhibit FAAH-2) member of this class, JNJ-40355003, was found to elevate the plasma levels of three fatt
PIPERAZINYL AND PIPERIDINYL UREAS AS MODULATORS OF FATTY ACID AMIDE HYDROLASE
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Page/Page column 101, (2008/06/13)
Compounds of formula (I) : wherein, Z is -N-or>CH; R1 is -H or -C1-4alkyl; Ar1 is 2-thiazolyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrimidinyl, 4-primidinyl, 5-pyrimidinyl, or phenyl, each unsubstituted or substituted at a carbon ring member with one or two Ra moieties; Wher each Ra moiety is independently selected from the group consisting of -C1-4alkyl, -C2-4alkenyl, -OH, -OC1-4alkyl, halo, -CF3, -OCF3, -SCF3, -SH, -S(O)0-2C1-4alkyl, -OSO2C1-4alkyl, -CO2C1-4alkyl, -CO2H, -COC1-4alkyl, -N(Rb)Rc, -SO2NRbRc, -NRbSO2Rc, -C(=O)NRbRc, -NO2, and -CN, wherein Rb and Rc are each independently -H or -C1-4alkyl; and Ar2 is defined in the claims are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity. Thus, the compounds may be administered to treat, e.g., anxiety, pain, inflammation, sleep disorders, eating disorders, or movement disorders (such as multiple sclerosis).
A Novel Cleavage Technique to Generate Small Molecule Compounds and Libraries via a Two-Resin System
Ouyang, Xiaohu,Armstrong, Robert W.,Murphy, Martin M.
, p. 1027 - 1032 (2007/10/03)
Application of organic synthesis to solid supports has led to the successful implementation of combinatorial chemistry in the drug discovery process. This paper describes a novel use of the Hofmann elimination of tetrasubstituted amine salts on solid-phas
4-Quinazolinyl-guanidines
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, (2008/06/13)
(2-Amino-4-quinazolinyl)-quanidines of the formula STR1 wherein R1, R2, R3, R4, R5 and n have the defined meanings, and their physiologically tolerable acid addition salts, process for preparing these compounds, pharmaceutical preparations containing them and their use as medicines.
