6578-89-8Relevant academic research and scientific papers
Synthesis, Characterization and Biological Evaluation of Some Novel Azo-Imine Compounds
Nair, Smitha,Palanisamy, P.,Sunitha, K.
, p. 663 - 667 (2022/02/22)
The oxidative cyclization of thiosemicarbazone (III) synthesized from reaction between substituted aryl aldehydes (I) with thiosemicarbazide (II) was done using ferric chloride as oxidative agent to get 2-amino-5-phenyl-1,3,4-thiadiazole (IV). 2-Amino-5-phenyl-1,3,4-thiadiazole was introduced in condensation reactions with substituted aldehydes to obtain benzylidene imine derivatives (VI)1-5. Further these were treated with sulphanilic acid to give new 2-{[5-phenyl-1,3,4-thiadiazole-2-imino] substituted benzene}diazenyl benzene sulfonic acid derivatives (VII)1-5. These derivatives were further characterized by FT-IR, 1H NMR and 13C NMR spectral studies and were screened for antibacterial, antifungal and antioxidant activities.
Synthesis and evaluation of some novel 1,3,4-thiadiazoles for antidiabetic activity
Pattan,Kittur,Sastry,Jadav,Thakur,Madamwar,Shinde
, p. 615 - 618 (2011/06/21)
A new series of 1,3,4-thiadiazole derivatives are synthesized and the structures of these compounds have been established on the basis of spectral and elemental analysis. All the compounds are evaluated for antidiabetic activity on albino rats. Most of th
