6583-42-2

Upstream product

• 100-52-7 benzaldehyde 
• 613-94-5 benzoic acid hydrazide 
• 31061-79-7 benzoic acid (4-chlorobenzylidene)hydrazide 
• 50882-37-6 C₁₄H₁₀Cl₂N₂ 
• 93-89-0 benzoic acid ethyl ester 
• 2002-03-1 2-amino-5-phenyl-1,3,4-thiadiazole 
• 104-88-1 4-chlorobenzaldehyde 
• 65-85-0 benzoic acid 

Downstream Products

• 122772-40-1 7-(4-Chloro-phenyl)-2,6-diphenyl-6,7-dihydro-[1,3,4]thiadiazolo[3,2-a][1,3,5]triazine-5-thione 
• 122772-44-5 7-(4-Chloro-phenyl)-2-phenyl-6-o-tolyl-6,7-dihydro-[1,3,4]thiadiazolo[3,2-a][1,3,5]triazine-5-thione 

Relevant academic research and scientific papers

Synthesis, Characterization and Biological Evaluation of Some Novel Azo-Imine Compounds

The oxidative cyclization of thiosemicarbazone (III) synthesized from reaction between substituted aryl aldehydes (I) with thiosemicarbazide (II) was done using ferric chloride as oxidative agent to get 2-amino-5-phenyl-1,3,4-thiadiazole (IV). 2-Amino-5-phenyl-1,3,4-thiadiazole was introduced in condensation reactions with substituted aldehydes to obtain benzylidene imine derivatives (VI)1-5. Further these were treated with sulphanilic acid to give new 2-{[5-phenyl-1,3,4-thiadiazole-2-imino] substituted benzene}diazenyl benzene sulfonic acid derivatives (VII)1-5. These derivatives were further characterized by FT-IR, 1H NMR and 13C NMR spectral studies and were screened for antibacterial, antifungal and antioxidant activities.

Studies on the synthesis and bioactivity of some thiadiazole derivatives

Several 2-aryl-3-(4-aryl-1,3,4-thiadiazolyl)-4-thiazolidinones 3 and several other fused heterocycles 5 have been prepared. Most of the compounds 3 have been screened for their fungicidal activity against two fungi Aspergillus clavatus and Aspergillus fum

Synthesis of Some Azomethine Derivatives of 2-Amino-5-phenyl-1,3,4-thiadiazole

Azomethines derived from 2-amino-5-phenyl-1,3,4-thiadiazole were prepared by fusion of the starling amine with corresponding carhonyl compound. The method ensures yields of target products up to 97%. The composition and structure of the products were conf

(4 + 2) Cycloaddition of conjugated azomethines to aryl isothiocyanates and fungitoxicity of the resulting 6,7-dihydro-1,3,4-thiadiazolo-s-triazine-5(H)-thiones

(4 + 2) Cycloaddition of conjugated azomethines, 5-aryl/aryloxymethyl-2-benzylideneamino-1,3,4-thiadiazoles (3a-l), to aryl isothiocyanates affords 2,6,7-trisubstituted 6,7-dihydro-1,3,4-thiadiazolo-s-triazine-5(H)-thiones (4a-l).The compounds 4a-l have been compared with Dithane M-45, a standard fungicide, for their antifungal activity against A. niger and F. oxysporium.

Unsaturated Compounds containing Nitrogen. Part 4. Further Reactions of 1-Chloro-2,3-diazabutadienes with S-Nucleophiles

1-Chloro-1,4-diaryl-2,3-diazabutadienes (Ar1CCl=NN=CHAr2), prepared by the reaction of thionyl chloride with aroylhydrazones (Ar1CONHN=CHAr2), react with thiosemicarbazide or thiocarbohydrazide to give 2-arylidenehydrazino-5-aryl-1,3,4-thiadiazoles, and with potassium thiocyanate to give 1-thiocyanato-1,4-diaryl-2,3-diazabutadienes which isomerize thermally to arylideneamino-5-aryl-1,3,4-thiadiazoles. 1-Chloro-1,4-diphenyl-2,3-diazabutadiene reacts with potassium ethylxanthate to give a 1-ethylxanthyl-2,3-diazabutadiene which on pyrolysis yields 2,5-diphenyl-1,3,4-thiadiazole.